Online ISSN: 2515-8260

Keywords : Inflammatory markers

Inflammatory markers and lipid profile based on age in asymptomatic individuals with or without family history of type 2 diabetes mellitus

Dr. Shreya Nigoskar, Bonala Sharat Babu

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1219-1224

Introduction: Although there was a weak positive link between inflammatory indicators and
serum lipid levels, assessing both of these parameters combined may aid in the early
detection and treatment of people who are at high risk for metabolic disorders like type 2
diabetes mellitus and other cardio vascular diseases.
Materials and Methods: This experiment was carried out at the Department of Biochemistry
research lab in India. The sample size was determined to be N=100 based on a 0.56
connection between visceral fat composition and oxidative stress and inflammation. The
study included students and apparently healthy cases between the ages of 18 and 30 who
followed DM patients in (n = 50). Individuals taking any medications for a health condition
that precludes them from performing sub-maximal exercise, as well as those who participate
in regular physical activity, yoga, or other biofeedback, were excluded from the study. Age
and gender matched ostensibly healthy persons with no family history of diabetes were
recruited for the control group (n = 50).
Results: Significant difference was noted in the inflammatory markers & the lipid profile
parameters except for the HDL. In individual with type 2 diabetes, worsening dyslipidemia
and inflammation over time raises concerns about the early onset of atherosclerosis. In the
absence of glycemic control, insulin treatment is of poor effect. Efforts to improve glycemic
control are required.
Conclusion:Lipid profile of an individual is associated to obesity, inflammation, vascular
function, and diabetes. Appropriate lifestyle adjustments may be performed to lower the
inflammatory markers and metabolic disorders. A greater understanding of the causes of
inflammatory markers and lipid profile aid in the development of specialized therapeutic
approaches for treatment of type 2 diabetes mellitus.

Assessment and Comparison of Ghrelin and Chemerin Levels in Gingival Crevicular Fluid and Serum as Predictive Biomarkers in Aggressive Periodontitis Patients: A Study Protocol

Dr. Pavan , Bajaj; Dr. Prasad V. , Dhadse; Dr. Vidya Baliga; Dr. Priyanka Jaiswal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2027-2033

Abstract: Background: Ghrelin is a recently described peptide hormone that is secreted
predominantly by the stomach. It induces appetite and thereby controls food intake and energy
balance. It has been also observed modulatory effects on the immune system and bone
metabolism. Chemerin binds to an orphan G coupled receptor which modulates the innate
immune system and chemotaxis of immature dendritic cells and macrophages. Objective:
Comparative evaluation of GCF & Serum “levels of Ghrelin and Chemerin” as the
(Predictive) biomarkers of inflammation in aggressive periodontitis. Methodology: Total 80
samples will be included and divided into two groups. Group I includes 40 GCF samples from
40 subjects with aggressive and Group II includes 40 Serum samples from 40 subjects with
aggressive periodontitis group. The GCF will be collected from the site with deepest probing
depth. Gingival index, probing pocket depth and clinical attachment level will be measured
one day before GCF collection to avoid stimulation of the sample and its contamination with
blood. The Ghrelin and Chemerin levels in GCF and serum samples will be measured using
an ELISA kit. Expected Result: