Online ISSN: 2515-8260

Keywords : Hemoglobin


Dr. Shyamkumar Sirsam, Dr. Payal Bobade, Dr. Rohit Dimbar, Dr. Rajat Sharma , Dr. Dhanshree Rajurkar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 3256-3264

Background: Postpartum anemia imposes a disproportionately substantial disease burden during a critical period of maternal-infant interaction. Postpartum anemia requires prevention and treatment not only for that particular period but also to ensure good health with enough iron stores at the start of the next pregnancy. Among various parenteral iron preparations, single-dose intravenous (FCM) ferric carboxymaltose is more effective to cure anemia.
Material & Methods:
This was an observational prospective interventional study in 120 anemic postnatal women in Government Medical College, Akola- Maharashtra. Patients with Hb <10 grams were assigned to this study and were given intravenous FCM. Data were collected and statistical analysis was performed. Treatment potency was assessed through repeat hemoglobin (Hb) and ferritin titers which indicate the iron (Fe) stores. Drug safety was assessed by the evaluation of drug reactions.
Results :
A significant rise in Hb, MCV, and ferritin levels was observed after 1 week and 1 month after receiving Inj.FCM. The mean change in the hemoglobin levels were 0.845 and 2.405 on day 7 and at day 28 respectively. Mean changes in the MCV levels were 3.06 and 6.42 on day 7 and on day 28 respectively. The mean change in the Sr. Ferritin levels was 102.56 ng / ml on day 28. This means the change in the Sr. Ferritin level was statistically significant with a ‘P’ value < 0.0001.
Intravenous ferric carboxymaltose is an efficacious and safe drug to treat postpartum anemia in women of reproductive age.


Dr. Ramya.S, Dr. Pagadpally Srinivas

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 7426-7433

BACKGROUND: Anemia is the world's most common nutritional deficiency disorder. Maternal anaemia has become one of the world's major health concerns and it is linked to negative maternal and foetal outcomes such as Maternal and perinatal mortality rates, premature birth, low birth weight, and certain anomalies have all increased.
OBJECTIVE: This study was conducted to determine the effect of maternal anemia with new born’s birth weight, and gestational age at delivery.
METHODOLOGY: This was an observational clinical study involving 200 pregnant women and their newborn. Every singleton live birth baby born was examined. The hemoglobin for 100 anemic mother and hemoglobin of 100 non anemic mother was considered and it was correlated with neonatal outcomes such as gestational age at birth and birth weight.
Results: The majority of the anemic mothers were from the lower class. Non anemic mothers were from lower middle class. Preterm births accounted for 25% in total, in which 17% preterm birth were born to anemic mothers. and low birth weights accounted for 45% in total in which 38% were born to anemic mother.
CONCLUSION: According to WHO data from 2018, anaemia in pregnancy affects 65-75% of pregnant women in India. Preterm births are 12.1% and low birth weights are 17.8% among babies born to anaemic mothers. In future, With the help of national health programme we should aim in reduction of incidence of anemia in pregnancy and their detrimental effect on new born.


Dr Ilaka Vasundhara Devi ,Dr.K.Venkateswarlu, Dr.R.S.Swaroopa Rani, Dr.Srirekha.P

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 637-644

Hemolytic specimens are common in laboratory practise, accounting for approximately 3% of
all samples referred to a clinical lab .It can have an impact on the results of analytes like
AST, LDH, potassium, and sodium. High glucose levels have been shown to interfere with
Jaffe creatinine assays in peritoneal dialysate, as well as creatinine, calcium, albumin,
chloride, and FT4 levels in serum . Diabetes, a rapidly growing chronic disease characterised
by hyperglycemia, has a 9.8percent prevalence in our state. As a result, the likelihood of
glucose acting as an interference factor is relatively high..

Detection of abnormal haemoglobin variants and its characterization among anaemicsby high performance liquid chromatography (HPLC): A prospective study from North India

Sushanta Chakma, Sumanta Das, Krishna Chakma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2552-2561

Background: Hemoglobinopathies are one of the most common inherited blood illnesses
in India and are one of the country's most serious public health issues. In India, it is
estimated that there are approximately 45 million carriers and 15,000 babies born with
hemoglobinopathies per year. The carrier rate of hemoglobinopathy in various Indian
demographic groups ranges from 3 to 17 percent. Automated cation-exchange High
Performance Liquid Chromatography (HPLC) has surfaced as an outstanding
screening tool for identifying this abnormal hemoglobin or thalassemic conditions. So,
the purpose of this study was to identify common haemoglobin disorders, in anaemia
patients using HPLC.

Neurophysiological Assessment And Cognition In Adult Females With Iron Deficiency Anaemia

Dr. Umme Kulsoom Sheema; Dr. Alka Rawekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 1923-1925

Abstract: Background: Iron deficiency anemia (IDA) is the most prevalent form of anemia
especially in developing countries. Females of child bearing age are vulnerable for developing
IDA due to menstrual blood loss, dietary deficiency, pregnancy and lactation. IDA is
diagnosed by low blood hemoglobin and serum ferritin levels which correlates with body iron
stores. Of the various biological effects of iron, there are many evidences that iron effects
normal neurological functioning and development. This forms the biological basis for the
behavioral and cognitive developmental delays observed in iron-deficient anemic infants and
children. Reduced levels of blood hemoglobin and serum ferritin has been positively correlated
with low cognitive score and altered evoked potentials in females with IDA. Lack of research
studies to know the effect of IDA on neurophysiological parameters like cognitive
performance, event related potential and brainstem auditory response are little explored in
Indian adult females.
Methods: Cognitive status is assessed using Montreal Cognitive Assessment (MoCA) scale
which is validated testing scale for diagnosis of Mild Cognitive Impairment and
neurophysiological assessment is done using auditory Event Related Potential (ERP / P300)
and Brainstem Evoked Response Audiometry (BERA). MoCA score, ERP and BERA values
will be compared in females with iron deficiency anemia and normal females and also
associated with blood hemoglobin and serum ferritin levels. IDA may impair Cognitive
performance and hearing in adult females which may have tremendous impact on
understanding of speech and problem solving in them.
Hence, the aim of the study is to confirm a relationship between IDA and neuro-cognitive
features using cognitive scale and evoked potentials in adult females.

Structural And Functional Diversity Of Microbial Globins

Shiv Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4022-4028

Hemoglobin and myoglobin are heme proteins that can bind oxygen reversibly and were first reported in vertebrates. Later on, occurrence of hemoglobin was found in all forms of life ranging from prokaryotes to eukaryotes. Myxobacteria are Gram-negative, rod-shaped eubacteria and that belong to delta proteobacteria. They predominantly thrive in soil and have very large genome size with high G+C content in comparison to other eubacteria. It is evident that the globins have been characterized predominantly from bacteria involved in photosynthesis, nitrogen fixation andpathogenicity, where these are implicated in and the protection of photosynthetic machinery from the oxidative damage,protection of nitrogen fixing enzyme from nitrosative and oxidative stress and the virulence of the host, respectively.


Fatmah S Alqahtany

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 3590-3599

Background: Anemia of newborns is a worldwide health concern. Since neonatal
anemia is associated with late neurological deficits, and is a leading cause of the risk
of perinatal mortality and requires urgent attention. Standard hemoglobin level for a
term newborn is 19.3±2.2 g/dL. Anemia of the newborns can be physiological,owing
to excessive blood loss, increased destruction of RBCor decreased production of
RBC. Newborn babies with anemia are pale, and may have tachypnea, tachycardia,
poor feeding, and hypotension with acute blood loss and jaundice when there is
hemolysis of RBC. Hemoglobin concentration is the best tool, for the diagnosis of
anemia in Newborns. The treatment depends on the underlying cause; Newborns, who
have rapidly lost large amounts of blood are treated with I/V fluids followed by blood
transfusion,reducing the blood loss due to repeated phlebotomy and blood extraction
for investigations may reduce the need of blood transfusion. Other treatments are
Autologous Placental Blood Transfusion, Erythropoietin therapy, and Nutritional

The Effect Of Giving Dates Syrup Combination (Phoenix Dactylifera) And Bee Pollen On Hemoglobin Levels In Pregnant Wistar Rats (Rattus Novergicus)

Fahriani .; Sartini .; Veni Hadju

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 182-189

Background: Anemia often results from iron deficiency in a pregnant woman as a result of a double iron needs resulting from a rise in blood volume, to meet a mother’s (prevent blood loss at birth) and fetal growth. Dates and bee pollen have the potential to increase hemoglobin because of its complex properties and compositions.
Objective of the study :This study aims to identify the effect of combination of dates and bee pollen syrup towards the hemoglobin level on the pregnant white wistar strain
Reseach method:This research used an experimental research design with randomized post test control group. It used simple random sampling technique by paying attention to inclusion and exclusion criteria, and obtain 28 pregnant white wistar strain rats. The samples were divided into 4 groups. The control group was given cmc solution intervention group was given dates syrup,bee pollen, and the combination of dates syrup and bee pollen,at a dose of 2ml/day for 20 days. Measurement of hemoglobin levels using a hematology analyzer.
Result: The results of this study analyzed using paired T test, Anova test with two factorial design and post Hoc LSD. This study shows that from the statistical test of hemoglobin levels, it obtained an average value in control group before 13.700±0.883 and after treatment 13.314±0.979 with a value (p=0,096,p>0.05), which means there is no difference after treatment while in the intervention group date syrup before treatment 12,500 ± 0.416 and after treatment 13,014 ± 0.644 with value (p = 0.179, p> 0.05) which means there is no difference after treatment. The bee pollen syrup group before treatment was 13.814 ± 0.823 and after treatment 14.014 ± 0.795 with value (p = 0.099, p> 0.05) which means there is no difference after treatment. whereas in the combination of date syrup and bee pollen groups before treatment was 12.971 ± 0.616 and after treatment 15.557± 0.378 with value (p=0.000, p<0.05) which means there is a difference after treatment.
Conclusion: The conclusion of this study is that there is an effect of giving a combination of dates syrup and bee pollen. It is hoped that the next researcher can make a combination of dates syrup and bee pollen which is given to pregnant woman

Dates And Hemoglobin Levels: Literature Review

Dwi Ayu Rahmawati; Suryani As’ ad; A.Wardihan Sinrang; Ridni Husnah

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 2364-2370

Objective: The aim of this systematic review is to review studies on the effect of dates on increasing hemoglobin levels in anemia
Methods: the method used is an electronic database that has been published through the online libraries PubMed and Sciendirect. The keywords used for article searches are based on research questions. Result: a review of six health articles stated that dates are effective for increasing hemoglobin levels. Dosage, timing of administration, type of dates, food intake, a person's health condition should be of particular concern in giving date palm interventions. Not only increase hemoglobin levels, dates can also play a role in increasing ferritin, hematocrit, transferring saturation and serum iron levels in the majority of people.
Conclusion: dates can be used as an additional alternative to increase hemoglobin levels. However, disease or systemic syndrome in each person should be a concern because it can affect the effectiveness of dates in increasing hemoglobin levels.