European Journal of Molecular & Clinical Medicine

Asthmatic symptoms characteristically come and go, with a time course of hours to days, resolving spontaneously with removal from the triggering stimulus or in response to antiasthmatic medications. Patients with asthma may remain asymptomatic for long periods of time. Report of symptoms that occur or worsen at night is a feature of asthma. The subjects recruited directly from the department of pulmonary medicine based on the inclusion and
exclusion criteria. Minimum 60 subjects needed for the study. The parameters of lung volumes (SVC, FVC, FEV1, FEV1/FVC%, FEV1/SVC%) recorded by ATS standardized MEDISOFT® spirometry. FEV1/SVC diagnosed obstruction in 33 out of 41 patients (80.49%) compared to FEV1/FVC which diagnosed obstruction in 16 out of 41 patients (39.02%) with statistical significance (p=0.000). The discrepancy is 41.47%.

Background:Bronchial asthma is a chronic inflammatory disease of airways in which many
cells and cellular elements play a role particularly mast cells, eosinophils, T lymphocytes,
macrophages, neutrophils and epithelial cells.Chronic bronchial asthma may cause pulmonary
arterial hypertension which causes RV hypertrophy and dilatation as well as systolic and
diastolic RV dysfunction. The level of right ventricular diastolic dysfunction depends on the
degree of right ventricular hypertrophy and pulmonary vascular resistance.
Aim of the study: The aim of this study wasto evaluatethe ventricular functions in patients with
bronchial asthma using Traditional Echocardiography and tissue Doppler imaging.
Patients and methods:This was a cross sectional study that included thirty-eight patients with
bronchial asthma. All patients were subjected to full history taking, clinical examination and
they underwent Echocardiography.
Results:Tricuspid and mitral E wave velocities were significantly lower among cases. Tricuspid
and mitral A wave Velocities were significantly higher among cases. No significant
differencewas found regarding any of the measured cardiac dimensions. No significant
statistical difference regarding fractional shortening was found.Right ventricular myocardial
performance (MPI) was higher in case group when compared to control group with no
significant statistical difference.
Conclusion:Early and late biventricular diastolic dysfunction was detectable in children with
bronchial asthma using conventionalDoppler echocardiography. The absolute value of right
ventricular tissue Doppler-derived MPI was increased in cases of bronchial asthma compared
with control subjects although the difference did not reach statistical significance.

Allergy is a pathology of countries with a high index of socio-economic development and most of all residents of large cities. By 2025, according to the WHO, 50% of the world's population will suffer from allergies [14]. This article examines the main risk factors for the development of allergic diseases in children under the age of 18 in Tashkent. The most significant factors were: the presence of an inherited predisposition on the line of one (RCh 1.9) or both parents (OR 5.6), closely related marriages between parents (RCh 2.8), the age of parents over 40 at the time of conception of the child (RCh 1.4) and some others.

This article presents the results of evaluating the therapeutic efficacy of
specific allergic vaccination in 77 children with allergy of micro-mite etiology. The age of
children was in the range of 7-14 years, including 7-12 years old  29 (37.7%), 12-14 years
old  48 (62.3%).In general, of the total number of patients (77) who received specific
treatment, excellent results were observed in 26 (33.7–4.2%). In this group of patients,
after treatment, all the main symptoms of the disease completely disappeared. Good results
were observed in 39 (50.6–4.4) patients. In this group of patients, most of the symptoms of
the disease disappeared or the intensity of their severity was weakened. Satisfactory results
were observed in 11.7% of patients. In this group of patients, the symptoms of the disease
remained, but the intensity of their manifestation was weakened. In 3.9% of patients, the
treatment effect was absent. It turned out that the therapeutic effectiveness of specific
therapy lasts for 1-3 years. So, good and excellent results were achieved after 1 year 
62.8%, after 2 years  55.4%, and after 3 years  50.0%. The use of a new method of
allergen-specific immunotherapy of children suffering from allergic diseases: the
combined method (inhalation of the allergen + its electrophoresis through the skin) of
immunotherapy compares favorably with the known traditional (multiple injection
methods) with great therapeutic efficiency, does not cause negative side local and general
reactions, does not give complications, lengthen remission.

Abstract: In recent years, serious and numerous advances have been made in the treatment
of bronchial asthma. These results are associated with the significant efficacy of inhaled
corticosteroids in topical diagnosis and pathogenetic treatment of bronchial asthma.
However, despite the results achieved, the fight against this disease is not satisfactory. In
patients with severe bronchial asthma, inhaled corticosteroids are more effective when
used in combination with β2-agonists. Almost every second asthma patient is concerned
about nighttime attacks. More than half of the patients had limited physical activity, and
one in three lost the ability to work. Most patients are forced to see a doctor because of the
exacerbation and progression of the disease.

The article provides data on the influence of environmental factors on the development of bronchial asthma in children living in the industrial regions of the Tashkent region. The increase in the air pollution index has led to an increase in the number of children suffering from bronchial asthma. The clinical features of bronchial asthma in children living in industrial regions is the predominance of the cough variant.

Abstract. In order to determine the role of polymorphic variants of the tumor necrosis
factor α gene (TNFα -308G> A) in the development and course of chronic respiratory
diseases, an analysis was made of the frequency of alleles and genotypes in patients with
bronchial asthma and chronic bronchitis and healthy individuals of the Uzbek population.
An analysis of the frequency distribution of genotypes and alleles of the studied gene
showed that risk allele A and genotype A/A and A/G are markers of an increased risk of
developing a disease of the bronchopulmonary system both in the group of patients with
bronchial asthma and in children with chronic bronchitis.

The study included 41 patients aged 36 to 64 years, suffering from BA, in whom the disease was complicated by pulmonary hypertension (PH). Patients were divided into 2 groups. The 1st group included 17 BA patients with II-III stage of severity with PH (average age 57.1 ± 1.5 years). The second group included 24 BA patients with AH (average age 57 ± 1.8 years). The control group consisted of 20 practically healthy individuals (HI), comparable in age.