Online ISSN: 2515-8260

Keywords : xerostomia

Assessment of onset and progression of chemoradiotherapy induced oral complications in head and neck cancer patients - An original research

Dr.Peeyush Sharma; Dr. Narendra Reddy Chittamuru; Dr. Saurabh. S. Pillai; Dr. Kedar Nath Nayak; Dr Tharini Satheesh; Dr Anish Nelson; Dr. Rahul VC Tiwari .

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 8752-8757

Aim: Purpose of the present research was to assess onset as well as progression of chemoradiotherapy (CRT) induced oral complications in head and neck cancer patients.
Methodology: A prospective study conducted among 40 patients with HNC undergoing CRT. Oral complications onset and grades of severity at different time points on a weekly basis for six weeks were assessed. Weekly pairwise comparisons of oral complications was done using the Friedman oneway repeated measure analysis of variance (ANOVA). The Chisquared test was done in oral candidiasis to determine the significance between groups (P < 0.05)
Results: Among 40 HNC patients who completed CRT and showed oral complications, 27 (67.5%) were males and 13 (32.5%) females, with peak age of 51–60 years (40%). All the oral complications had onset first noticed in the second week of CRT except dysphagia that occurred in the first week. A statistically significant difference in oral complications grading during week 1 to week 6 with P < 0.001 was present. All the patients had oral mucositis (OM), xerostomia, and dysgeusia observed in the fourth week, and dysphagia in fifth week. Severity in grading was noticed in the sixth week for all the complications.

Study of oral manifestations in chronic kidney disease in vindhya Region

Karuna Jindwani , Keshav Singh , Ayush Jain

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2336-2347

Background: Normal kidney secretes nitrogenous waste product, regulate volume and
acid /base balance of plasma and synthesize erythropoietin, 25-(OH)2- cholecalciferol
and renin. Chronic kidney disease (CKD) is caused by a progressive and irreversible
decline in the number of nephrons. A wide variety of oral manifestations occurs in CKD
patients. Determination and identification of these manifestations will improve the
quality of life in these patients.
Methods: Thus, this cross-sectional study was conducted in the Department of
Medicine, Sanjay Gandhi Memorial Hospital (SGMH), associated with Shyam Shah
Medical College (SSMC), Rewa, in the Vindhya region between February 2019 and
August 2020.
Results: Out of 127 patients, maximum prevalence of oral manifestations occurring was
pallor (93.70%), xerostomia (84.25%), halitosis (72.44%), sore throat (64.56%), lip
pigmentation (63.77%), periodontitis (48.81%). High Urea levels were found to be
highly significant when correlated with halitosis (p<0.00052). Xerostomia was found
significant when correlated with duration of dialysis (<1 year) with p<0.032.
Conclusions: Manifestations of CKD are common during the progression of uremia. In
the patients studied, the impact of CKD on the oral cavity was evidenced by significant
changes, which pointed to an inter-relationship between oral health and CKD.


Dr S.Aafiya Reshma; Dr. L. Malathi; Dr. N.Aravindha Babu; Dr.E. Rajesh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1798-1803

Menopause is a physiological activity in women which brings changes at both systemic and oral level. At old age, oral hygiene and oral health becomes a major problem and the dentist are the ones who find those changes in the body throughout the menopause. The gums and teeth are more prone to changes in hormones that take place before menopause and slows down body’s capacity to fight back minor infections too. This article reviews about dry mouth during menopause which is of major concern which causes xerostomia.


Dr.Abarna Jawahar; Dr.G. Maragathavalli; Dr.Manjari Chaudhary

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 986-996

The aim of the study was to estimate the prevalence of salivary gland diseases in patients visiting a private
dental college. A retrospective analysis was conducted on patients who visited the Department of Oral
Medicine from March 2019 to March 2020.Clinically diagnosed cases of salivary gland diseases which
included salivary gland neoplasms, xerostomia, necrotizing sialometaplasia, mucocele, ranula, sjogren’s
syndrome, sialodochitis, sialadenitis were included in the study.The details of each case were reviewed
from an electronic database.From the study we found that 17 patients were diagnosed with salivary gland
disease.The most commonly observed salivary gland disease was mucocele of the lip with a frequency of
41.17% in the study population followed by xerostomia (17.65%).Salivary gland disease can occur due to
variable causes and might significantly affect the quality of life and daily functioning.Only with a
thorough knowledge of the subject it is possible to detect the diseases of the salivary gland in their early
stage and manage them more efficiently.