Online ISSN: 2515-8260

Keywords : Oral Lichen Planus


Efficacy of toluidine blue, lugol's iodine and acetic acid for detecting oral lesions of Leukoplakia– A cross-sectional study

Dr. Devashree Shukla, Dr. Chandresh Shukla, Dr. Kaushal Pati Tripathi, Dr. Dilraj Singh, Dr. Ayushi Sharma, Dr. Sommyta Kathal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 3008-3013

Background:The life expectancy and prognosis of patients suffering from oral
cancer will be considerably improved if oral cancer is detected and treated early. To
augment clinical examination and improve diagnosis, adjunctive diagnostic aids such as
vital staining have been introduced.
Aim:The present research examined the diagnostic efficacy of acetic acid (2%), lugol's
iodine (3% dilution), and toluidine blue (1%), to diagnose oral leukoplakia.
Materials and Methods:A cross-sectional study was undertaken at a hospital with 45
randomly selected subjects who had clinically verified cases of oral leukoplakia. Acetic
acid, lugol's iodine, and toluidine blue were applied in respective order on oral lesions.
The results of each staining were then compared to the clinical and histopathologic
diagnoses. A control group was made up of cases diagnosed with epithelial hyperplasia.
Numbers and percentages are used to present the information. To compare the effects
of toluidine blue application, toluidine blue, and acetic acid, the Chi square test was
utilised. In terms of its utility in predicting the dysplastic character of the lesion, the
sensitivity and specificity test was used to determine diagnostic efficiency and reliability.
Results:Toluidine blue staining and lugol's iodine staining both had a sensitivity of 91.59
percent, while the former had a specificity of 23.33 percent and the latter had a
specificity of 12.22 percent. The sensitivity of the acetic acid test was 58.25 percent and
the specificity was 34.44 percent. There was no statistically significant difference
between the staining with three agents and the histopathologic variations in multiple
comparisons.

ORAL LICHEN PLANUS – A RETROSPECTIVE CLINICAL STUDY IN A TERTIARY CARE CENTRE

Ch. Rama Mohan, M. Nagaswetha, S.Praveen Kumar, B. Sankar Kumar, Ch.Sudha Rani, G. Narasimha Rao Netha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11126-11137

Background:Oral lichen planus (OLP) is a chronic inflammatory disorder with a
relatively high prevalence varying from 0.9 % to 1.2%. It may be confined to oral
cavity or associated with the skin, nails and other mucosal sites. Oral lesions are
chronic, rarely undergo spontaneous remission and are often a source of morbidity.
OBJECTIVE - To investigate the epidemiological and clinical characteristics of oral
lichen planus (OLP) in a group of patients.
Materials and Methods: This is retrospective study done at Gandhi Hospital from 2017
to 2019. A total of 64 lichen planus patients with oral involvement were included. OLP
is diagnosed based on the morphology and associated lesions on the skin, nails or other
mucosa. A biopsy was done in doubtful cases.
Results: Out of 64 studied patients females(41) outnumbered males(23) .The common
age group was 30-60yrs. Isolated OLP was observed in 42%, with cutaneous LP 50%,
with nail involvement 3%, and with genital mucosa 4 %. Buccal mucosa is the
commonest site (84%) followed by tongue 28% and lip 20%. LP involving the lower lip
with actinic changes 5(39%) and pigmentation in 8(61%). The common patterns
observed were reticular 65.6%, erosive 11% and pigmented 11%. Other associations
were submucosal fibrosis in 6, diabetes 10, hypothyroidism 4, vitiligo 1, retro-positive 4,
HCV in 2.
Conclusion: In our study reticular pattern involving the buccal mucosa was the
commonest. Our study showed that LP involving the lower lip was mimicking actinic
cheilitis which may be differentiated. Association of LP with HCV was seen in only in
3.1 % of cases. Regular follow-up was needed for erosive or ulcerative and atrophic LP.

A Comparative Analysis of different Treatment Modalities of Oral Lichen Planus

Sonali Roy, Archana Kumari, Praveen Chandra

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1287-1291

Background:Lichen planus (LP) is a common, chronic inflammatory mucocutaneous
disease of unknown etiology and putative autoimmune pathogenesis. The present study
compared different treatment modalities of oral lichen planus.
Materials & Methods: 78 clinically and histopathological diagnosed cases of oral lichen
planus were divided into 2 groups of 39 each. Group I patients were given 0.1% tacrolimus
cream and group II patients were given 0.05% topical application of clobetasol propionate.
Parameters such as pain on VAS and size of the lesion was recorded at baseline, after 3
weeks and 6 weeks.
Results: The mean size (cm2) in group I was 5.8, 3.4 and 1.6 and in group II was 4.7, 3.2
and 1.2 at baseline, 3 weeks and 6 weeks respectively. A non- significant difference was
observed (P> 0.05). The mean VAS was 2.8, 1.4 and 0.6 in group I and 2.9, 1.8 and 0.8 at
baseline, 3 weeks and 6 weeks in group II respectively. The difference was significant (P<
0.05).
Conclusion: 0.1% tacrolimus reduced size of the lesion and pain score efficiently than
0.5% clobetasol propionate in patients of oral lichen planus.

Curcumin alone and curcumin with prednisone in management Oral Lichen Planuspatients

Dr.Rutika Naik, Dr.Lubna Nazneen,Dr Akshay Dhobley,Dr.Aparna Sharma Thombre,Dr.Ullas Saxena,Dr.Suparna Kosta

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3784-3788

Background:Oral Lichen Planus is a chronic inflammatory mucocutaneous disease affecting
the oral cavity, skin and nails. The present study compared curcumin alone and curcumin
with prednisone in management of cases of oral lichen planus.
Materials & Methods:The present study was conducted on 68 patients diagnosed clinically and
histologically as oral lichen planus which were divided randomly into 2 groups of 34 each. In
group I patients, Curenext oral gel was prescribed for topical application for 15 minutes, three
times a day. In group II patients, a paste of crushed tablet of prednisone and curenext oral gel
was prescribed for 15 minutes, three times a day. All patients were recalled after 10 days for
1st follow up and 20 days later for 2nd follow up and reticulation, erosion and pain on VAS
were recorded.
Results: The mean reticulation score at baseline in group I was 1.82, in group II was 1.80, on
10th day in group I was 1.60 and in group II was 1.14 and on 20th day in group I was 0.86 and
in group II was 1.42. The difference was significant (P< 0.05). The mean erosion score at
baseline in group I was 2.32, in group II was 2.30, on 10th day in group I was 1.95 and in
group II was 1.45 and on 20th day in group I was 0.82 and in group II was 0.10. The
difference was significant (P< 0.05). The mean VAS score at baseline in group I was 4.10, in
group II was 3.94, on 10th day in group I was 3.24 and in group II was 1.92 and on 20th day in
group I was 1.26 and in group II was 0.06. The difference was significant (P< 0.05).
Conclusion:Authors found that combination of curcumin and prednisone proved to be
effective as compared to curcumin alone in patients of oral lichen planus

PREVALENCE OF EROSIVE LICHEN PLANUS : A RETROSPECTIVE STUDY

T. Santhosh; Jayanth kumar Vadivel; Sankari malaiappan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1547-1554

Oral Lichen Planus(OLP) is a chronic inflammatory disease which has potential to transform into a malignancy mainly into squamous cell carcinoma. This study was done to evaluate the prevalence of erosive OLP among all OLP cases in a particular ethinic group of people. Materials and method :Data retrieved was from 86000 case sheets from saveetha dental college. The case sheets showed 94 patients with OLP. Most of the patients were in the age group of 50-60 years with a female predominance. 48 patients were erosive OLP variant. A chi square analysis showed erosive OLP had a tendency to occur more in the buccal mucosa(p<0.05). A chi square analysis to compare gender was not significant(p>0.05) This study shows that there is more prevalence of erosive OLP with a female predominance and affecting the buccal mucoa.