Online ISSN: 2515-8260

Keywords : Severity

" A cross-sectional observational Study to assess the severity of coronavirus disease 2019 according to Clinical value of immune inflammatory markers"

Dr. Sarika Rawat Dr. Sunil Bajoliya Dr. Sachin Kumbhare Dr Roshan Mandloi Dr. Ranjeet Badole

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 955-961

Title-" A cross-sectional observational  Study to assess the severity of coronavirus disease 2019 according to Clinical value of immune  inflammatory markers"
Background: In Wuhan, China, since December 2019, a new strain of pneumonia has appeared and spread quickly over the world. The World Health Organization determined that a separate strain of coronavirus, designated COVID-19, caused this pneumonia (WHO). This unique coronavirus was identified as acute respiratory syndrome coronavirus 2 based on phylogeny, taxonomy, and accepted practise (SARS-COV2).
Objective: a cross-sectional observational study to show the co-relation between inflammatory markers and the severity of disease
Materials and Methods: a total of 250 patients were selected who are microbiologically covid positive and ready to give consent were included in the study. There basic test will be done.
Result- There is preponderance of male gender among the patients 147 were male 103 were female. The mean age of participant is 43 ±2.825 (±6.57%)65 patient were immediately required the either oxygen or mechanical ventilation,among all this 26 patient were died. Among this entire 65 patient, 21 patients have raise CRP level,14 have raised IL -6 Level among them all 26 were have raised D-Dimer .
Conclusion- Our study showed that high level of D-Dimer, IL-6 and CRP was independent risk factors for assessing the severity of COVID-19. IL-6 played a determiningrole in the severity of SARS-COV2 and had a potential value for monitoring the process of severe cases.

To assess the severity of COVID-19 in relation toclinical value of immune inflammatory markers: An observational study

Dr. Preety Motiyani, Dr. RS Meena, Dr. Dileep Dandotiya, Dr. Mamta Meena, Dr. Jitendra Rai

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 657-662

Background: Since December 2019, an novel type of pneumonia emergedin
Wuhan,China,and rapidly transmitted to wholeglobe. This pneumonia was verified to
be caused by a different strain coronavirus and named as coronavirus disease
2019(COVID-19) bythe World Health Organization (WHO). Based on
phylogeny,taxonomy and established practice, this novel coronavirus was designated
as severe acute respiratory syndrome coronavirus2 (SARS-COV2).
Objectives: To show the co-relation between inflammatory markers and the severity of
COVID-19 disease

A comparative Study of Liver enzymes and hematological parameters indenguefever casesandhealthycontrols

Dr Mahantesh BB,Dr KavithaMM , Dr Subhash N, Dr SangappaVK

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 156-160

Dengue is the most serious viral infection in recent years, resulting in major morbititesand mortality. This was a hospital based comparative study done from July – August2019. The purpose of this study was to estimate the hematological parameters and liverenzymes in dengue patients which could help to detect the severity of the
disease andintervene early. Participants included 75 cases and 75 healthy controls. Hemoglobin,WBC count, Platelet count along with SGOT and SGPT levels were analysed. Our studyshowed elevated SGOT AND SGPT levels of which SGOT is more elevated .WBC andplatelet count were reduced and showed negative correlation with
SGOT and SGPTvalues.Hence thisstudyshowedliver enzymesget affected by dengue and also itssever ity can beassessed by knowing hematological parameters which aids in early intervention and initiatethetreatment sooner.

Role of C-Reactive Protein and Neutrophil Lymphocyte Ratio in Predicting Severity of Acute Appendicitis

Puli Vineela, N.Ashok Vardhan Kumar, MdShadab Jaseem, J. Parthasarathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2435-2442

Background:The aim of this study is to analyse the role of c- reactive protein and neutrophil lymphocyte ratio accuracy in diagnosis of acute appendicitis and perforated appendicitis.
Materials and Methods: The present study is ROLE OF C-REACTIVE PROTEIN AND NEUTROPHIL LYMPHOCYTE RATIO IN PREDICTING SEVERITY OF ACUTE APPENDICITIS done at Kamineni Institute of Medical Sciences, Narketpally from October 2018 to September 2020.
Results: 100 cases of acute appendicitis which were admitted in kamineni institute of medical sciences were studied. The statistical data and analysis of the cases studied during this period are presented in this study out of 100 cases 14 were managed conservatively and 86 were subjected to surgery, 4 had no inflammatory changes on histopathology and 82 had histopathological features confirming acute appendicitis. Acute appendicitis more common in males than females with a ratio of 2.22:1 with complications also being more common in males. Incidence of acute appendicitis was highest in age group ranging from 20-30 years , with complicated appendicitis being more common in the age distribution of 35.87 +/-18.31 years. Most patients present with pain predominantly in right iliac fossa (100%) followed by nausea/vomiting in 82% and fever in 78% cases. Total leucocyte count was found to be elevated in 86% of individuals with elevations in range of 15825+/-4575 in patients with complicated appendicitis. Neutrophil lymphocyte ratio was found to be elevated in 86% of individuals with elevation in range of 10.6+/-5.49 in patients with complicated appendicitis. CRP values were found to be elevated in 68% of cases. In patients with uncomplicated appendicitis 52% showed elevation of CRP levels whereas in patients with complicated appendicitis 87% showed elevation of CRP levels.
Conclusion: CRP and neutrophil lymphocyte ratio were found to be elevated in cases of acute appendicitis with complications. Elevation in neutrophil lymphocyte ration and c - reactive protein levels can be used to anticipate severity and complications in patients of acute appendicitis.

Evaluation of Serum Interleukin-6 in Lichen Planus

Mohamed Metwalli, MD, Hoda. AIbraheem, MD, Hager Abu bakr MSc. FathiaKhattab MD

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3603-3611

Background: Lichen planus (LP) is animmune mediated inflammatorydiseaseof skin and
mucous membranes without a clear etiology. Interleukin-6 (IL-6) is a pro-inflammatory
cytokinewith variousbiologicaland pathological impactson immunity, acute phase response
andinflammation. ExcessiveIL-6production can play a role in the pathogenesis of several
pathological conditionslike psoriasis.
Aim:This study aimed to evaluate serum IL-6 levels inLP patients alongwithassessment
ofitscorrelation with disease severity.
Patients and methods: Twenty-one adult patients with LP as well astwenty-one healthy adult
controls were enrolled in the study. The total score of LP severity was estimated for all
patientsby calculation of the affected body surface area in cutaneous LP patients and clinical
scoring system with visual analogue scale for pain assessment for oral LP.Serum IL-6 levels
were measured in all participants using enzyme-linked immunosorbent assay.
Results:The mean serumIL-6 levels were significantly higher in patients than controls (P <
.002). A positive correlation wasnoticed between serum IL-6 with both cutaneous LP (P
<0.004) and oral LP (P <0.005) severities.

Predictive Value Of 14-3-3 Eta Protein as A Novel Biomarker in Juvenile Idiopathic Arthritis (Oligoarticular Type): Relation to Activity and Severity of The Disease

Amany Abo Elsoud, Nahla I. Elattar, Dina A. Abd Elhafeezc, Ibrahim T. Abdelal

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 4543-4551

Background: Juvenile idiopathic arthritis (JIA) is a term that encompasses all forms of
arthritis that begin before a patient is aged 16 years that persist for more than 6 weeks and
are of unknown origin. It is the most common childhood chronic rheumatic disease and
causes much disability. We investigated the relation of serum 14-3-3 η (eta) protein in
oligoarticular JIA (OJIA) and; the disease activity and severity.
Methods: This study is a case control study including 14 JIA patients and 14 control
group. Patients were (6 males and 8 females).14-3-3η was measured for all patients and
control volunteers by enzyme-linked immunosorbent assay (ELISA) technique. ANA was
measured by indirect immunofluorescence (IIF) technique. Disease activity was assessed
by the Juvenile Arthritis Disease Activity Score27 (JADAS-27). Functional ability was
assessed by childhood health assessment questionnaire (CHAQ), and disease severity was
assessed by juvenile arthritis damage index (JADI). Radiological damage was assessed by
Poznanski score.
Results: Elevated 14-3-3 η levels were detected in 5/14 (35.7%) patients. Positivity for 14-
3-3 η was significantly related to disease activity, severity and ANA. Positivity for 14-3-3 η
had no significant correlation with CHAQ or Posnanski score.
Conclusion: Serum 14-3-3 η can be detected in oligoarticular JIA patients, and appears to
correlate with disease activity, severity and (ANA). But no correlation with CHAQ or
Poznanski score.


Ilankizhai RJ; Dr. Ravindra Kumar Jain; Dr. Madhulaxmi M

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 216-223

Numerous studies in the past have been conducted to determine the prevalence of malocclusion in different populations. These show extreme variations and it is only right to determine the prevalence in a referred population. Class III malocclusion even though it is the least common, treatment planning and treatment is quite difficult, thus characteristics of class III malocclusion need to be studied in detail.The aim of the study is to evaluate the prevalence of crowding among patients with class III malocclusion visiting Saveetha dental college and hospitals. A retrospective study was done using case sheets of patients visiting the university hospital from June 2019- February 2020. About 100 case sheets of patients visiting the department of orthodontics containing information on malocclusion type and crowding was retrieved and analysed using SPSS 20.0. The study included 100 patients out of which 74% were males and 26% were females.Crowding was observed in 51% of the patients with class III malocclusion. Out of which 62.75% of the patients were reported to have minimal crowding ,31.37% had moderate crowding and 5.88% had severe crowding of the mandibular incisors. There was no statistically significant association between age, gender, and severity of crowding as determined by pearson's chi-square tests.Within the limits of the study, it can be concluded that mild mandibular crowding was the most common finding in class III malocclusion patients.


Umayal. S; Pradeep Kumar; R Smiline Girija. A.S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1827-1833

Dental fluorosis is a sign of prolonged high fluoride exposure. The aim of the study is to assess the severity of dental fluorosis among the patients visiting a Dental College in Chennai, Tamilnadu. A retrospective institution based study was conducted by evaluating and analysing 291 patient case records visiting a dental hospital from December(2019) to March(2020) who had signs of dental fluorosis. Data such as age, gender, type of dental fluorosis were documented from the online database of saveetha dental college - DIAS Dental Information Archiving Software. Ethical approval was obtained by the institutional ethical board at Saveetha University. The data was examined by two examiners. The data collected was reviewed and subjected to statistical analysis using IBM SPSS software version 20.0. The present study shows Females and middle aged patients with dental fluorosis visit dental hospitals more frequently.