European Journal of Molecular & Clinical Medicine

Background:Bronchial asthma is a chronic inflammatory disease of airways in which many
cells and cellular elements play a role particularly mast cells, eosinophils, T lymphocytes,
macrophages, neutrophils and epithelial cells.Chronic bronchial asthma may cause pulmonary
arterial hypertension which causes RV hypertrophy and dilatation as well as systolic and
diastolic RV dysfunction. The level of right ventricular diastolic dysfunction depends on the
degree of right ventricular hypertrophy and pulmonary vascular resistance.
Aim of the study: The aim of this study wasto evaluatethe ventricular functions in patients with
bronchial asthma using Traditional Echocardiography and tissue Doppler imaging.
Patients and methods:This was a cross sectional study that included thirty-eight patients with
bronchial asthma. All patients were subjected to full history taking, clinical examination and
they underwent Echocardiography.
Results:Tricuspid and mitral E wave velocities were significantly lower among cases. Tricuspid
and mitral A wave Velocities were significantly higher among cases. No significant
differencewas found regarding any of the measured cardiac dimensions. No significant
statistical difference regarding fractional shortening was found.Right ventricular myocardial
performance (MPI) was higher in case group when compared to control group with no
significant statistical difference.
Conclusion:Early and late biventricular diastolic dysfunction was detectable in children with
bronchial asthma using conventionalDoppler echocardiography. The absolute value of right
ventricular tissue Doppler-derived MPI was increased in cases of bronchial asthma compared
with control subjects although the difference did not reach statistical significance.

According to the World Health Organization (WHO), cardiovascular disease (CVD) is the leading cause of death and disability in countries around the world, with ST segment elevated myocardial infarction (STEMI) leading the way. Despite advances such as the widespread introduction of many effective drugs, angioplasty and surgical treatments into clinical practice, CVD kills 17.3 million people annually, accounting for 30% of all deaths worldwide. This figure is projected to increase to 23.6 million by 2030. In the world, including in Uzbekistan, over the past two decades there has been an increase in morbidity and mortality from cardiovascular pathology.

Background:Cardiovascular diseases (CVD) are the top most cause of death in the world. As per world health organization (WHO), greater number of people die of CVDs than any other cause.Out of the CVDs predominant mortality is attributed to coronary artery disease(CAD) which includes stable CAD and unstable CAD (which can manifest as unstable angina, NSTEMI or STEMI) . Hence the present study was undertaken at our tertiary care centre to assess different indices of RV function by Echocardiography within 48 hours of onset of symptoms in 1st episode of acute IWMI and to correlate it with the site of lesion in CAG.

Correlation dependence of the parameters of N - terminal cerebral natriuretic (NT-ProBNP) peptide and echocardiographic parameters for the diagnosis of pulmonary hypertension in children with CHD. For the study, 81 children aged 1 to 34 months were examined. The first group of CHD children without pulmonary hypertension, the second group - 56 CHD children with pulmonary hypertension. The results of our study show a statistically significant relationship between NT-ProBNP levels and structural features and pancreatic function during the development of PH with CHD.

Cardiomyopathy is a severe pathology, which requires careful
study of clinical parameters and data of functional diagnostics methods (ECG,
ECHO) for early detection. The study aimed to study the role of clinical and
instrumental, biochemical, and immunological investigation methods for early
detection and prognosis of cardiomyopathy course in children. Materials and
methods of study: 85 children with cardiomyopathy under 18 years of age were
examined, including 60 children with dilated cardiomyopathy (DCMP), 16
children with hypertrophic cardiomyopathy (HCMP) and 9 children with
restriction cardiomyopathy (RCMP) who were hospitalized in the
cardioreumatology department of the Republican Specialized Scientific-
Practical Medical Center of Pediatrics of the Ministry of Health of the Republic
of Uzbekistan. The control group consisted of 30 practically healthy children.