European Journal of Molecular & Clinical Medicine

Alcohol is most commonly abused drug worldwide. Alcohol use has also been shown
to have numerous effects on the cardiovascular system other than heart failure.It has
been associated with arrhythmia(eg.atrial fibrillation ,ectopics),hypertension and
sudden death [1] .
METHODS:
This is a hospital based cross-sectional study carried out in 100 chronic alcoholics
admiited at Dr.PSIMS&RF, Chinnoutapalli ,tertiary care, teaching hospital in South India for a period of 2 years.Their cardiovascular function is evaluated by
Electrocardiogram and Echocardiogram.
RESULTS:
Out of 100 patients, In the study group 94% were males and 6% were
females.Maximum incidence of Alcoholics was seen between 3 rd to 6 th Decade of
life.Mean age was 43.1 ±11.9 years .
Most common abnormality observed was sinus tachycardia(10%) followed by
Qt prolongation (7%),LVH and AF(5%),VPC(4%),NSC and RBBB(3%),APC(2%).
Most common echo abnormality was Increased LAD size(14%),increased
RVSP (12%),Increased thickness in IVS and Posterior wall(11%),EDD,EDS,EF,FS
abnormality was observed in 10% patients. Other findings like MR,TR,PAH seen in
1%,TR,PAH in 5%,MR IN 4 % population,remaining 90 % are normal. In Echo final
impression of LVH Seen in 11% and DCM was seen in 10%Population. Prevalance of
cardiovascular abnormalities In patients with chronic alcoholism was ECG 39 %
ECH0 21%
CONCLUSIONS: Early screening by means of ECHO and ECG can be useful in
preventing the progression to irreversible changes.Alcohol de-addiction and
counseling should be encouraged

Magnesium deficiency leads to the progression of atheromatous plaques which occurs as a result of hyperlipidemia. Myocardial infarction is one of the most common causes of mortality where its prognosis depends upon various factors.This study is designed to know the contribution of magnesium levels in the serum of acute MI patients to the occurrence of arrhythmias.
Materials & Methods: This observational cross-sectional study was conducted in the Medicine Department, Govt. Medical College, Barmer, Rajasthan, India during one year period. A total of 30 patients of AMI were enrolled in this study. They were diagnosed with AMI on the basis of clinical symptoms, cardiac biomarker levels and/or Electrocardiography (ECG) findings. For all the patients, serum magnesium levels on day 1 and day 5 were measured and its association was observed with the clinical consequences.
Results: In this study group of 30 cases, 25 were males and 5 were female patients with a male-female ratio of 5:1. The mean value of serum magnesium on day-1 those with arrhythmias is 1.62±0.23 those without arrhythmias is 2.03±0.49 (p<0.001). There is a significant difference in the magnesium level in patients with arrhythmias and without arrhythmias. The serum magnesium level in patients with arrhythmia on Day-5 is 1.93±0.26 and in those without arrhythmia is 2.52±0.61. The difference between these two is found to be statistically significant with p- value (p<0.001).
Conclusion: We concluded that patients with acute myocardial infarction with low magnesium levels are more prone to develop ventricular arrhythmias compared to those who are having normal magnesium levels.