Keywords : Coagulation markers
Study the role of coagulation markers to evaluate the morbidity and mortality of snake bite victims
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 1, Pages 4317-4323
Background: The deficiency of snake bite management in such areas is multi-causal and requires joint collaborative efforts from researchers, anti-venom manufacturers, policy makers, public health authorities and international funders. Coagulopathy is a common manifestation in some of these cases and its abnormality can be detected by blood coagulation tests.17 There are very few references in the literature related to coagulation parameter abnormalities after snake bite. Therefore this study was undertaken to study hematological profile of snake bite cases. Aim & Objective: 1. To study the role of coagulation markers to evaluate the morbidity and mortality of snake bite victims.2. study the haematological profile in snake bite patients.3. To determine incidence of vasculotoxic snake bite among all snake bite in a tertiary care hospital. Methods: A hospital based prospective cross-sectional study. Study setting: Pathology Department of tertiary care centre. Study population: All patients admitted in tertiary care center with history of snake bite. Sample size:100. Results: majority of patients of snake bite belongs to age group 31-40 yrs contributing 28 % of total cases, followed by age group 21-30 (27%). Also it was seen that 70 % of snake bite cases belongs in age group 21-50 yr. majority of patients with history of snake bite were males contributing 65%. Snake bites were more common in males as compared to females (35%). Among identified snake bites the most common species involved was Russel viper (48.98%) followed by cobra (31.91%) and common krait (19.14%). Majority of snake bite patients showed vasculotoxic manifaestations (67%) attributable to viperine bites. 33 % snake bite victims showed neuroparalytic manifaestations. 27% snake bite patients have APTT > 30 seconds.26% of snake bite victims had PT> 15 sec .44% had platelet count <100000. Increased leucocyte count > 11000 was seen in 62% patients and 54% victims showed WBCT>20 minutes. Survival rate of snake bite cases was 93 %. Mortality rate of snake bite victims was 7%. Association between Prothrombin time and mortality among snake bite patients statistically significant at p>.05. Conclusions: First line of coagulation markers PT, APTT should be considered as first line of investigations for any suspected coagulation abnormality in snake bite patients.