Online ISSN: 2515-8260

Keywords : Anti-epileptic activity

Effect Of Areca Catechuextract On Maximal Electroconvulsive Shock Induced Seizure In Rats With Special Emphasis On Oxidative Stress And Histological Changes In The Brain

Sukesh Bhat, Thirunavukkarasu, Eesha B R, SenthilkumarSivanesan .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 3316-3328

In this study, we looked at the anti-epileptic properties of an Areca catechu fruit hydroalcoholic extract in electrically induced seizures in Wistar albino rats, with a focus on oxidative stress and histopathological changes in different areas of the brain. The hydroalcoholic extract of Areca catechu fruit (1g/kg) and (2 g/kg) were tested for anti-epileptic activity in Wistaralbino rats during a maximal electroconvulsive shock-induced seizure using an electroconvulsiometer. The hydroalcoholic extract of Areca catechu significantly decreased the tonic hind limb extension (THLE) duration and protected rats from the seizures induced by maximal electroconvulsive shock. The study concluded that an alcoholic extract of the Areca catechu fruit has antiepileptic properties because it shortens the duration of the extensor phase of seizures.