European Journal of Molecular & Clinical Medicine

Eosinophilic granulomatosis with polyangiitis (EGPA) previously known as Churg-strauss syndrome is a multisystem disorder most commonly involving the lungs. It is a form of vasculitis that targets small to medium-sized blood vessels. It is a necrotizing granulomatous inflammation that is eosinophil-rich and frequently affects the respiratory system. It is also associated with difficult-to-treat asthma and eosinophilia. We describe a case of a 49-year-old man with documented severe asthma who presented with proximal myopathy and asthma exacerbation. Blood investigations showed that he had eosinophilia. Mononeuritis multiplex was confirmed by NCV (Nerve conduction velocity). Transbronchial lung biopsy and nerve biopsy proved vasculitis with eosinophils confirming the diagnosis of EGPA.This case highlights the diagnostic challenges with the manifestations of EGPA in a case of difficult-to-treat asthma.