Keywords : Bax, Bcl-xl
COLON CANCER AND THE MOLECULAR DOCKING INTERACTION OF ENDOGENOUS GLUTATHIONE PEROXIDASE ON APOPTOTIC MARKER
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 649-658
Background: In both men and women, colon tumor is the third highest cause of tumor death.. It is located at the digestive tracts lower end. Daily workout may prevent the tumor by inducing endogenous glutathione peroxidase. Nearly 1 million patients receive a diagnosis of colorectal tumor. Over 50,000 people die from this tumor annually.
Aim: To analyse the role of endogenous glutathione peroxidase on apoptotic markers through molecular docking interaction.
Materials and Methods: The molecular docking analysis is a bioinformatic study conducted in private dental college. Exercise induced endogenous glutathione peroxidase is used as target protein The interaction of glutathione peroxidase with protein relevant to colon tumor namely Bcl-2, Bcl-xl and Bax are included for docking analysis. The protein structure is retrieved using protein data bank, protein protein docking done using patch dock server followed by visualisation of protein - protein interaction using pymol.
Results: The surface representation of glutathione with Bcl-2, Bcl-xl and Bax complex showed good shape complementarity. It shows the positive interaction between glutathione peroxidase with Bcl-2, Bcl-xl, Bax proteins and might have a protective role against colon tumor.
Conclusion: The results concluded that exercise-induced glutathione peroxidase endogenously has interaction with Bcl-xl, Bcl-2, Bax protein and might have a protective role against colon tumor. Exercise is good for both mental and physical health. Regular physical activity improves your overall health. It can improve memory and also reduce the risk factors of chronic diseases.