European Journal of Molecular & Clinical Medicine

Exercise has been implicated in modulating dopamine in a major amount as neurotransmission, increasing blood flow, etc. The role of exercise in tumor risk reduction, there is now convincing and vital evidence that exercise reduces melanoma and also other tumors. This has to be practiced in each and every place where tumor has grown. The goal of the study is to study the impact of exercise induced dopamine replica in modulating the apoptotic signaling pathway in human melanoma.
The melanoma cell line of human cell (A375) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s  test.

Background: In both men and women, colon tumor is the third highest cause of tumor death.. It  is located at the digestive tracts lower end. Daily workout may prevent the tumor by inducing endogenous glutathione peroxidase. Nearly 1 million patients receive a diagnosis of colorectal tumor. Over 50,000 people die from this tumor annually.
Aim: To analyse the role of endogenous glutathione peroxidase on apoptotic markers through molecular docking interaction.
Materials and Methods: The molecular docking analysis is a bioinformatic study conducted in private dental college. Exercise induced endogenous glutathione peroxidase is used as target protein The interaction of glutathione peroxidase with protein relevant to colon tumor namely Bcl-2, Bcl-xl and Bax are included for docking analysis. The protein structure is retrieved using protein data bank, protein protein docking done using patch dock server followed by visualisation of protein - protein interaction using pymol.
Results: The surface representation of glutathione with  Bcl-2, Bcl-xl and Bax complex showed good shape complementarity. It shows the positive interaction between glutathione peroxidase with Bcl-2, Bcl-xl, Bax proteins and might have a protective role against colon tumor.
Conclusion: The results concluded that exercise-induced glutathione peroxidase endogenously has interaction with Bcl-xl, Bcl-2, Bax protein and might have a protective role against colon tumor. Exercise is good for both mental and physical health. Regular physical activity improves your overall health.  It can improve memory and also reduce the risk factors of chronic diseases.

During exercise we release a lot of hormones and neurotransmitters. Dopamine is one among the hormones which is released in several parts of the mid brain during exercise. It is said that exercise can help to avoid many diseases and even cancer.. In 2020 the number of cases diagnosed were 104,610 all around the world .In this study we analysed the role of endogenous dopamine replica over gene expression of Apoptotic and tumor suppressor gene against colon cancer prevention.
Human colon cancer cell line (HT -29) was brought from NCCS, Pune, India. Cell viability test and Gene expression analysis were carried out for apoptotic and tumor suppressor gene using MTT and PCR respectively. The results were analyzed using appropriate statistical tools using ANOVA and Duncan’s test.

Background: Tumor is a disease caused by abnormal cells dividing out of control. Lung tumor is a type of tumor that primarily affects smokers. Coughing, wheezing, chest pain, and other symptoms of lung tumor include these. Tecoma stans, popularly known as yellow bells, flowering perennial shrub endemic to the United States that belongs to the Bignoniaceae family of trumpet vines. It possesses antimicrobial, antispasmodic, antidiabetic, antibacterial, and trypsin inhibitor effects, among other things.
Aim: to investigate on the lung tumour cell line A549, Tecoma stans hydroethanolic leaf extract has an antioxidant and anti-proliferative effect.