Online ISSN: 2515-8260

Keywords : 4-diones

Synthesis, antimicrobial activity and Molecular docking study of some novel thiazolidine-2,4-dione derivatives

Pankaj Sharma, Chandra Shekhar Sharma

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 6075-6087

A series of novel thiazolidine-2,4-diones was synthesized and investigated for antimicrobial activity. The structures of all synthesized compounds were confirmed by means of elemental analysis, IR, 1H NMR, and LCMS. All compounds were evaluated for antimicrobial activity cup plate method against S. aureus, B. anthracis, P. aeruginosa, E. coli, C. albicans and A. niger. Compounds 2d and 2l showed significant activity against gram positive and gram negative bacteria. In case of antifungal activity, the zone of inhibition was ranging from 10 to 23 mm and the compounds 2c and 2e showed significant activity against the fungal strains as compared with fluconazole.