Online ISSN: 2515-8260

Keywords : Renal Function


Vijaitha S M, MDSabiullah

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11527-11532

Background:Thyroid hormones influence renal development, renal hemodynamic, glomerular filtration rate (GFR), electrolytes, and water homeostasis. The location of the present study is situated at dDepartment of Biochemistry, Maheswara Medical College, Hyderabad with moderate prevalence of thyroid dysfunctions, especially hypothyroidism. The objective of this observational cross-sectional study is to substantiate the effects of thyroid hormonal status on kidney by estimating serum creatinine, serum urea, albumin-to-creatinine ratio (ACR), and estimated GFR (eGFR) among primary hypothyroid patients with age- and sex-matched control group. The collected blood and urine samples from the study population have been estimated for the study parameters. Both Chronic Kidney Disease Epidemiology (CKD- EPI) equation and four- variable Modification of Diet in Renal Disease (MDRD) Study equation were used to calculate eGFR. In the present study the mean values of serum creatinine, urea, and ACR are significantly increased among untreated patients with hypothyroidism, with the decrease in the eGFR, in comparison to healthy control group (p < 0.001). The results of eGFR and ACR are signifi cantly correlated with thyroid-stimulating hormone (TSH) values. Statistically significant alteration in renal function parameters is associated with untreated primary hypothyroidism. Moreover, with the initiation of the treatment for the same can cause reversal of the altered status of renal function.


C.V. Sarada, Md. Masood Ahmed Shareef

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1634-1639

Background:Thyroid function has been suggested to have a relationship with kidney function and chronic kidney disease. Present study was aimed to study renal function tests in patients with hypothyroidism attending a tertiary care hospital.
Materials and Methods: Present study was hospital based, case-control study, conducted in Cases (Patients 21-60 years, of either sex, newly diagnosed cases of hypothyroidism, attending the medicine outpatient department, willing to participate) & controls (healthy age-matched subjects).
Results: In present study 100 cases & 100 case-controlled matches were studied. Age, gender & BMI were comparable among cases & controls, difference was not statistically significant. Among cases 26 had overt hypothyroidism & 74 had subclinical hypothyroidism. We compared T3, T4, TSH, Urea and Creatinine values among cases & controls. TSH and Creatinine levels were more among cases as compared to controls & difference was statistically significant. While T3, T4 & Urea levels were comparable among cases & controls, difference was not statistically significant. Pearson correlation was significant for values between TSH and serum creatinine while correlation between TSH and serum urea was not significant.
Conclusion: Subclinical hypothyroid state is associated with a consistent elevation in the serum creatinine levels due to a decrease in the GFR.