European Journal of Molecular & Clinical Medicine

Background: Peripheral Arterial Disease (PAD) is a slowly progressive atherosclerotic disease usually characterized by occlusion of lower limb arteries, ultimately causing acute or chronic limb ischemia. The PAD is largely under diagnosed and under treated because of unawareness of patients on claudication symptoms and present to the hospital at later stages with complications5. .
Study Design: The study design is of case series.

Aim of the Study: To study the various risk factors in terms of age, sex, occupation, pre-existing cardiovascular or metabolic diseases and other factors like smoking etc. involved in the development of gangrene in lower extremities.
To evaluate different clinical features of individuals with lower limb ischemia due to PAD.
Results: This study was done in the Department of General Surgery, Mamata General Hospital, Khammam, Telangana state from December 2018 to December 2020. A total number of 30 cases were included in this study, which satisfied the inclusion and exclusion criteria. The following conclusions were derived from the present study.
• Diabetes mellitus, hyperlipidemia, and hypertension are the modifiable risk factors for PAD. Patients at risk of developing PAD can be identified with regular monitoring of the risk factors and proper preventive medication and management.
• Medical treatment for preventing CV events in PAD subjects seems to be cost-effective. Among the evaluated treatment strategies, ACE-i displayed the largest reduction in event rates to the highest mean QALY. Aspirin treatment does not appear to be cost-effective due to the low reduction in event rates.
• Conclusion: Early diagnosis and treatment of PAD are critically important to reduce the risk of complications like gangrene in PAD and to minimize the risk of lower extremity amputations, risk of long-term disability, and to improve quality of life.