European Journal of Molecular & Clinical Medicine

Headache is a commonly reported complaint among Covid19 patients, and cases of chronic head aching have lately been documented several weeks after illness recovery. Raised intracranial pressure (ICP) plays a key role in the causation of head ache, Raised ICP if not timely treated leads to brain complications. The study aims to compare the incidence of elevated ICP in post-covid populations to that of the general population, and the objective of study is to assess the features of raised intracranial pressure in post covid and in general population by using CT
Method:
Current study was conducted on 150 subjects who have headache symptoms, in which 75 had Covid history and other 75 from general population. The brain CT image of this 150 subjects evaluated to assess ICP And for identifying the comparison between post covid subject with normal subject. This is study done at DR. PSIMS&RF,Gannavaram,AndhraPradesh.CT brain examinations were performed on 16slice SEIMENS CT machine in the department of radiodiagnosis. CT brain images of patients with headache complaints were evaluated.
Results:
CT Brain images of 150 subjects who came with complaints of headache were evaluated.75 patients among them had past covid history, rest 75 were taken as general population group. In the post covid group 32 patients (42%) had raised ICP features&18 patients (24%) in general population had raised ICP features. Bilateral tortuous optic nerve sheaths were found in 34 patients (45%) in post covid group as opposed to 21 patients (28%) in the general population group. Partial empty sella was found in 35 patients (46%) of post covid group as opposed to patients 21(28%)in the general population group. Patients who had both partial empty sella and bilateral optic nerve sheath dilatation were considered to be of raised ICP to rule out other etiologies

Background information -Gastrointestinal stromal tumors (GISTs)arise from the interstitial
cell of Cajal are the most common mesenchymal neoplasms of the gastrointestinal tract. The
imaging features of GISTs have only been described in very limited studies. Hence the
present study was designed to evaluate CT/MRI findings of Gastrointestinal stromal tumors
and to identify appropriate biopsy options. Further To identify the criteria on cross sectional
imaging, which determine operability and non-operability of gastrointestinal stromal tumors.
Methods- 36 clinically suspected GIST and subsequent histopathologically proven cases
were selected. Based on imaging findings appropriate biopsy options were considered i.e.,
percutaneous image guided CT/ ultrasound guided/ Endosonological/Laparoscopic or open
biopsies. Lesions which are classified as operable are subjected to surgical excision if other
conditions are favorable for surgery. Intraoperative findings were studied for correlation and
agreement with findings on cross sectional imaging. Inoperable cases were planned for
imatinib therapy and close follow-up.
Results and conclusion - We found that the cross-sectional imaging findings were accurate
in predicting the operability of GISTs. In this study cross sectional imaging (CT/MRI) had
sensitivity of 95.83%, PPV was 100% and Diagnostic Accuracy was 95.83% for GISTs.Cross
sectional imaging findings were very helpful in characterizing the tumor, deciding the
appropriate biopsy option and operability and non-operability in cases of GISTs.Overall,
Cross sectional imaging played a vital role in deciding the best therapeutic options for the
patients.Pre-operative staging is incredibly important to see the operability of tumor. It also
helps to search for lymph nodal involvement and metastasis preoperatively.It also helps in
post-operative follow-up or follow-up in patients on imatinib to look for therapeutic response
and in detection of local recurrence and metastasis.