European Journal of Molecular & Clinical Medicine

Background: Split Thickness Skin Graft (STSG) is graft that only contains the epidermis and a tiny portion of the dermis. Donor sites for split-thickness skin grafts can either be covered with different types of dressings. In this study, we looked at the function of collagen sheet dressing at the skin graft donor site and how it affected the healing parameters and compared it with conventional betadine dressing.
Methods: An prospective study conducted in 60 patients general surgery department. Collagen dressing or Betadine dressing over donor site were performed among study subjects by randomised process. 
Results: Mean age of 60 study sample was 42.58 years (SD - 9.812 years), with 53 (88%) male and 7 (12%) female in study. Collagen-based dressings for the donor site for split-thickness grafts produced better results in terms of the rate of healing, post-operative pain, and length of hospital stay than the typical betadine gauze dressing whereas in case of total cost of the treatment and patient satisfaction, Collagen Dressings and Betadine Dressings both show almost similar result.
Conclusion: Early pain alleviation and a high ulcer healing rate are provided with collagen dressing over conventional betadine dressing.

Introduction: Diabetic foot has become the common indication for hospital admissions
among diabetics. The diabetic foot commonly begins as an ulcer. So rapid and extensive
is the underlying damage that approximately 20% of these patients end up with
amputation. The present study has been performed to compare the efficacy of collagen
dressing with that of conventional dressing materials like silver sulfadiazine,
nadifloxacin, povidone iodine.
Materials and Methods: Fifty patients (40 males and 10 females) were procured to be
included to experimental group who were treated using collagen dressing and they form
the study group. Control treatment was performed on 25 patients (21 males and 4
females) at the same period. All the quantitative values were noted as mean± standard
deviations.
Results: 1. The final ulcer sizes (by the 3-week measurement) ranged between 0.2 and
4.2 cm2 (mean, 1.11 ± 1.19 cm2) in the experimental group, and ranged between 0.1 and
12.8 cm2 (mean, 2.52 ± 2.61 cm2) in the control group. It was found that all of 25
patients of the experimental group were reported with shrinkage of wound area and
depth over 30% at the third week regardless of wound location, duration, and grade. In
contrast, the improvement of only 5 ulcers in area over 30% at the third week was
observed, and 6 in depth.
Conclusion: Collagen dressing also might also provide supplementary advantages of
patients’ comfort and compliance as well as maintenance of ideal healing environment.
In order to confirm the usefulness and wound healing potential of collagen dressing in
the management of diabetic foot ulcers, future research with longer follow-up periods
should be conducted.