European Journal of Molecular & Clinical Medicine

Arsenic is a well-known carcinogen that contributes to the progression of multiple cancers and has recently been reported to be one of the most effective new anticancer agents in the treatment of various cancer types, together with acute promyelocytic leukemia (APL) as well as other solid tumors. However, the effect of arsenic and its compoundson different metabolic processes are still unknown. In cancer therapy, the advancement of arsenic trioxide in the treatment of different cancers has a unique history. The glorious past of arsenic and its different forms with a significant focus on arsenic trioxide as a therapeutic approach along with the mode of action, pathogenicity, pharmacokinetics, health hazards, current clinical studies of arsenic trioxide is illustrated in this study.Besides, how arsenic strengthens its deleterious effects and how it can effectively contribute to new therapeutic developments must also be understood.Therefore an urgent need for a deeper understanding of arsenic's contradictory effect, which could have the potential to be an effective medication for different kinds of cancers. In this review, we emphasized its selective channels that would have been beneficial in focusing attention over its real role in terms of toxicity as well as potential medications for the treatment of various forms of cancer.

Pollution or contamination plays a major part in dreadful health hazards. Water, the most essential entity for life is being consumed without the knowledge of contaminants. Arsenic (As III) above 10μg/L is regarded to be poisonous to life and causes lung or skin cancer and cardiovascular geotaxis, mutagenic &carcinogenic effects. Contamination of As may not only occurs in under or drinking water but also in sea water which may be a health threat to aquatic lives. Arsenic decontamination need to be strictly adopted upon any form of water purification. A special technique for the determination by express sensing of arsenic ionic level in water was examined on a Smooth or Glassy carbon electrode (GCE) with nano Gold transformation in 0.5 M H2SO4. The nano Gold was setup using a cycling potential continuously ranging from 0.619 to-0.481 V (vs. HAuCl4.3H2O) Chloro Auric Acid in 0.5 M H2SO4 solution. The Gold nano particles are electro- deposited on GCE. The electrode was examined by Differential Pulse Voltammetry (DPV), Anodic Stripping Voltammetry (ASV), Linear Sweep Voltammetry (LSV) and cyclic Voltammetry (CV). After optimization, a LOD (Level Of Detection) of 0.9 parts per billion (ppb) was achieved with a 60s transformation at -0.94 V in 0.5 M H2SO4whereas the WHO’s (World Health Organization) maximum allowable arsenic level is 10 ppb, in drinking water. Mercury Mercurious Sulphate (MMS) was used as standard reference electrode. The developed sensor was evaluated for copper ion interference and was found to have no interfering effect due to ionic copper which is the most potential obstructing ionic species in ionic arsenic determination.