Online ISSN: 2515-8260

Keywords : Biogenic silver nanoparticles (PTNPs)

Hepatoprotective potential of Pterocarpus santalinus mediated biogenic silver nanoparticles against induced hepatitis in male albino rats

Ravi Kumar Nulakachandanam, ShanmugamBasha, Ganesh Babu D, Bharath Kumar Bukkapatnam, VasaviKapuluru, Rajasekhar Maram

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 5, Pages 1998-2007

Hepatitis infection burdens have been increasing and alarming around the globe in recent
years. The mainstream therapeutics of hepatitis infections are non-specific with numerous
side effects. To combat viral hepatitis, a novel therapeutic platform is needed. In the present
study, we explored a novel biogenic approach of nanotechnology as an alternative therapeutic
platform for treating hepatitis. Biogenic silver nanoparticles (PTNPs) synthesised from
Pterocarpus santalinus bark extract were used in the treatment against induced hepatitis. DGalactosamine
was given to male Wistar strain rats to induce hepatitis similar to viral
hepatitis inflammations. The hepatic serum markers, Alanine aminotransferase and Aspartate
aminotransferase were examined during the hepatitis conditions. The results obtained
indicated that the Alanine aminotransferase and Aspartate aminotransferase enzyme levels
were significantly reduced after the treatment with PTNPs. The hepatoprotective activity
demonstrated from PTNPs would find application in alternate therapeutics in the treatment of