Online ISSN: 2515-8260

Keywords : Peritoneal fluid

ClinicalStudy ofBacteriologicalPatterns andAntibiotic Sensitivity in Secondary Peritonitis

Naveen Banoth, Venkatesh A

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2461-2472

Background:Intra-abdominal infections have been treated with various antibiotic regimens. These infections have been treated with single-agent and combination treatments. But no one therapy has been proven superior. The study's main goal is to examine the bacterial patterns in peritoneal fluid from surgical peritonitis patients and assess their antibiotic sensitivity and resistance.
Materials and Methods: It is a cross sectional observation research conducted in January 2020 to May 2021 which was conducted in JSS Hospital Mysuru. Analyzed data was in rates, proportions, and percentages. The sample includes 100 cases of secondary peritonitis caused by hollow viscus perforation, where preoperative peritoneal fluid samples were analysed for bacterial culture and sensitivity.
Results: Out of 100 samples, 50 had bacterial growth. The most common bacteria were E. coli. These were Acinobacter (6%), Candida (4%), Citrobacter (1%), Klebsiella (11%) and Serratia (2%). (4 percent). 77.5 percent of E. coli were sensitive to Ceftriaxone, 75% to Piperacillin-tazobactam, and 99.1 percent to Meropenem. In 40% of cases, E.coli was multidrug resistant. Most Klebsiellapneumoniae were responsive to ceftriaxone, piperacillin-tazobactam, and meropenem. Ciprofloxacin, Ceftriaxone, and Meropenem were all sensitive to Proteus mirabilis. 25.2 percent of cases were multidrug resistant bacteria.
Conclusion: The results of this investigation identify the organisms usually isolated from peritoneal fluid, their susceptibility and resistance to broad spectrum antibiotics. It shows the common gramme negative isolates and the current antibiotic resistance concern in these individuals. The most common microorganism found in gastrointestinal perforations is Escherichia coli. In most cases, numerous gramme negative bacilli develop polymicrobially. Antibiotic-resistant microorganisms, notably multidrug resistant Escherichia coli, are increasing in number. Third generation cephalosporins are becoming more resistant. In multidrug resistant organisms, Meropenem and Tigecycline seem to be the best options.

Clinicobacterial Study of Perforation Peritonitis and its Impact on Postoperative Wound Complications

Pragyey Nawlakhe, Sandeep Jain,Hemant Ahirwar, Devendra Chowdhary, Arvind Rai

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5693-5700

Background:Surgical wound infection continues to consume a considerable portion of
health care finance. Even though the complete elimination of wound infections is not
possible, a reduction of observed wound infection rate to a minimum level could have
marked benefits in terms of both patients comfort and resources used .As many
surgeons believe that routine culture of peritoneal fluid in patients of secondary
peritonitis offer no useful information & no clinical benefits, not too many studies had
been done to support the utility of peritoneal fluid culture as a important parameter in
preventing SSI.. This study was aimed to study relevance of peritoneal fluid culture in
relation to its impact on surgical site infections and to know the most common organism
associated with peritonitis & SSI with their antibiotic sensitivity in our hospital. Also to
know if any correlation present between organism isolated from peritoneal fluid &
organism isolated from pus from wound.