Online ISSN: 2515-8260

Keywords : Subclinical Hypothyroid

A Hospital Based Prospective Study to Evaluate the Lipid Profile in Patients Having Subclinical Hypothyroidism and Type-II Diabetes Mellitus

Usha Rangey Chouhan, Pradeep Kumar Chouhan

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2324-2330

Background: Both Hypothyroidism and Diabetes alter lipid levels and are the leading causes of dyslipidemia in the current era. However, the pattern of altered lipid profile varies in the two diseases. Hence, the glycemic control in diabetics with Hypothyroidism (overt and subclinical) may not be good despite strict dietary and lifestyle modifications, and there are conflicting reports regarding this observation. The aim of this study to evaluated the lipid profile in patients having subclinical hypothyroidism and type-ii diabetes mellitus.
Materials& Methods: A hospital based prospective study done on 100 Patients aged above 40 years with a past history of type-2 Diabetes mellitus attending medicine OPD in government district hospital, Sirohi, Rajasthan, India during one year period. Lipid profile included Total cholesterol, LDL cholesterol, HDL cholesterol and plasma triglycerides. Fasting thyroid profile including plasma free T3, free T4, and plasma TSH were obtained using standard assays. The data collected were entered in the proforma and subjected to statistical analysis.
Results: Subclinical Hypothyroidism was present in 12% of cases.4% had overt hypothyroidism. Females were significantly higher in proportion than males among those who had subclinical hypothyroidism. The presence of subclinical hypothyroidism was not significantly related to higher levels of HbA1C. There was no significant effect on Total and LDL cholesterol, and HDL cholesterol, in patients with subclinical hypothyroidism.
Conclusion: We concluded that there is a significant increase in the incidence of subclinical hypothyroidism in patients with type 2 diabetes mellitus and this increase is associated with a significant rise in the triglyceride levels.


C.V. Sarada, Md. Masood Ahmed Shareef

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1634-1639

Background:Thyroid function has been suggested to have a relationship with kidney function and chronic kidney disease. Present study was aimed to study renal function tests in patients with hypothyroidism attending a tertiary care hospital.
Materials and Methods: Present study was hospital based, case-control study, conducted in Cases (Patients 21-60 years, of either sex, newly diagnosed cases of hypothyroidism, attending the medicine outpatient department, willing to participate) & controls (healthy age-matched subjects).
Results: In present study 100 cases & 100 case-controlled matches were studied. Age, gender & BMI were comparable among cases & controls, difference was not statistically significant. Among cases 26 had overt hypothyroidism & 74 had subclinical hypothyroidism. We compared T3, T4, TSH, Urea and Creatinine values among cases & controls. TSH and Creatinine levels were more among cases as compared to controls & difference was statistically significant. While T3, T4 & Urea levels were comparable among cases & controls, difference was not statistically significant. Pearson correlation was significant for values between TSH and serum creatinine while correlation between TSH and serum urea was not significant.
Conclusion: Subclinical hypothyroid state is associated with a consistent elevation in the serum creatinine levels due to a decrease in the GFR.