Online ISSN: 2515-8260

Keywords : PRP

Evaluation of the Survival of the Implants after the Treatment with the Platelet-Rich Plasma (PRP): An Original Study

Dr. Poornachandra Rao Thondati, Dr. Bandi Chandra Lekha, Dr. Lakshmipuram Achyuth Kumar, Dr. Padavala Sushma,Madhur Arora, Dr. Swathi Pravallika Langanooru .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 2, Pages 1507-1518

Background: To ensure long-term implant success, the atrophic maxilla frequently needs bone augmentation before to implant implantation. The application of platelet-rich plasma (PRP) during maxillary augmentation was studied in a prior prospective clinical research. The immediate results revealed no benefit from PRP. The purpose of this study was to assess the long-term effects of PRP on the survival and success of dental implants in the same patient group as the previous study.
Materials and methods: In this investigation, 50 patients from the previous study who had been treated for maxillary atrophy with dental implants and autologous bone grafts from the iliac crest were taken into account. 30 patients had treatment using a split-mouth design, where one randomly selected side received additional PRP treatment while the other served as the control side. 20 patients received one-sided treatment and were randomized to either the PRP or the control group. The patients from the prior study had their implants followed up with on average 5 years later. Two distinct success metrics were used to assess the success of the implants.
Results: In this study, 30 patients (20 women and 10 males) were examined. The PRP group consisted of 15 patients (10 female, 5 male), whereas the control group consisted of 15 patients (10 female, 5 male). There were 240 implants installed altogether. The PRP group received 100 implants while the control group received 100 implants. The survival rate: 95, while in the control group had a survival rate of 98%. The cumulative likelihood of survival after 5 years was 94% in the PRP group and 98% in the control group, with no discernible difference between the two groups. Albrektson criteria were used to calculate the cumulative success probability, and a higher significant difference was obtained for the control group (p = 0.05).
Conclusion: PRP did not have a positive effect on the success and longevity of implants.

To analyze Internal and External Quality Controls in Blood Bank

Rahul , Akash Kumar, Dr. Anshu Kumar Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 6, Pages 755-767

Most quality control programs in blood banking are concerned exclusively with control of research center testing and staff and don't assess different region of the blood donation center or decide the capability of all work force in the presentation of administrative assignments. To accomplish the last objectives in our quality control program, during a 15-month time frame, 1,143 purposeful mistakes were placed into routine parts of all blood donation center exercises and afterward painstakingly checked and controlled. Of 498, 400, and 245 mistakes shipped off the workplace, nursing, and lab regions, separately, 12 (2.4%), 58 (14.5%), and 29 (11.8%) blunders were not recognized. Presentation of this program was likewise joined by a huge expansion in the quantity of genuine blunders that were distinguished and probably had not recently been perceived. The quantity of genuine blunders identified expanded from 4 to 43 to 73 during months 0 to 6, 7 to 12, and 13 to 15 of this review. Examination and recording of every blunder on an Error Report Form has allowed assessment of both faculty and frameworks and ensuing execution of restorative activity

Evaluation of clinico-radiological outcomes in patients with lumbar degenerative disc diseases treated with intradiscal PRP versus steroids: A prospective double blinded randomized controlled trial

Dr. Bhupinder Singh Brar, Dr. Vivek Jha, Dr. Guncha Kalia, Dr. Bhandari Vaibhav, Dr. Neelam Gupta, Dr. Mandeep Kaur Nanda, Dr. Monika Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 1079-1088

Context: To evaluate clinico-radiological outcomes in patients with lumbar degenerative disc
diseases treated with intradiscal PRP versus steroids.
Design: Prospective double blinded randomized controlled trial.
Aims: The aim of the study was to compare and assess radiological changes and clinical
outcome in patients with degenerative disc diseases when treated with intradiscal platelet rich
plasma and intradiscal steroid.
Objectives: To compare clinical outcome in PRP and steroid treated patients, to compare
radiological changes in PRP and steroid treated patients, to assess clinical outcome in PRP
and steroid treated patients at subsequent follow ups, to assess radiological changes in PRP
and steroid treated patients at subsequent follow up.
Settings and Design: Prospective double blinded randomized controlled trial.
Methods and Material: Adults (18-50 years) with chronic low back ache (> 6 months) nonradiating
who were unresponsive to conservative treatment. A total 40 patients were
randomized to receive intradiscal PRP (Group A) or steroid (Group B) after provocative
discography in the department of Orthopaedics in Maharishi Markandeshwar Medical
College and Hospital, Solan between the time period of November 2019 to September 2021
based on inclusion and exclusion criteria were enrolled for platelet rich plasma and steroid
infiltration in a randomized manner. Pain relief as assessed by change in VAS score,
functional assessment using change in Modified oswestry disability index (MODI). Pfirrman
and MSU grades as assessed by MRI.

A prospective study on the treatment of chronic non-healing ulcers using autologous platelet rich plasma

Neharika, Brajesh Pathak, Sanjiv Bhatia, Ravi Pratap Singh Rajey

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 9945-9953

Aim: To assess the effect of Platelet Rich Plasma (PRP) in non-healing ulcers.
Material and methods: It was a hospital based prospective cross-sectional &
observational study between July 2020 to June 2021, at Hind institute of medical
sciences, Safedabad, Barabanki. The history and examination were done bedside. In
cases where the condition of patients doesn’t warrant giving history, their relatives or
attendants were interviewed. A predesigned pretested semi-structured questionnaire
was filled by the interviewer. Data was entered in Microsoft Excel sheet. The study area
was General Surgery, Orthopaedics& medicine department, of Hind Institute of
Medical Sciences, Safedabad, Barabanki.Pus culture and sensitivity were sent then after
cleaning the wound with normal saline and betadine solution, already centrifuged
platelet rich plasma was injected subcutaneously inside, in the periphery of wound and
spread over floor of ulcer then dress with non-absorbent dressing. 1st dressing was
changed on the 3rd day of injection then dressing was changed on every 7th day.We
evaluated the effect of 1 dose of platelet rich plasma injection efficacy in wound/ulcer
healing & reduction in wound/ulcer size and follow-up by visual inspection.
Results: At admission, the mean wound area was 388.6±25.35 mm2 which was reduced
Furtherreductionwasobservedat 14th day (49.66%) and 21st day (64.40%) and these
reductions were statisticallysignificant (p value <0.001).At 21st day the % change in
volume was maximum for venous ulcer (69.25±4.43 %) and minimum for post
traumatic (65.27±9.11 %). No significant difference was found in % change in volume at
21st day among various ulcer types (p value =0.336).
Conclusion: Based on this study observation and result, we proposed that platelet rich
plasma is a safe bio-compatible, cost-effective, less time-consuming procedure and does
not require sophisticated equipment.


Dr. Sumit Pal Singh, Dr. Manmeet Singh , Dr. Shubham Pandoh, Dr. Anil Gupta, Dr. Nitish Sharma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2382-2386

Background: Osteoarthritis (OA) is a chronic, non-inflammatory rheumatologic disease which affects the synovial joints. The present study was conducted to assess the role of PRP in management of osteoarthritis of the knee.
Materials & Methods: 65 patients of osteoarthritis of the knee of both genders were enrolled.
Cartilage thicknesses were measured radiologically by ultrasound before and at third and sixth months after treatment. The severity of pain was evaluated by using VAS.
Results: Out of 65 patients, males were 30 and females were 35. Right side was involved in 34 cases and left in 31 cases. The mean VAS before treatment was 5.4, after 3 months it was 2.3 and after 6 months it was 0.8. The difference was significant (P< 0.05). The mean cartilage thickness before treatment was 0.5 mm, after 3 months was 0.7 mm and after 6 months it was 0.8 mm. The difference was significant (P< 0.05).
Conclusion: PRP is found to be effective in management of cases of osteoarthritis of the knee.