European Journal of Molecular & Clinical Medicine

Aim &Objective: To study Incidence of different types of heart disease in pregnancy and Maternal and Foetal Outcome of Heart Disease in Pregnancy in A Tertiary Care Centre.
Material & Methods: Prospective observation study was conducted in the Depatment of Obstetrics and Gynecologya tertiary care hospital in Aurangabad district of Maharashtra state from October 2019 to September 2021. All patients who fulfilled the inclusion and exclusion criteria during the study period were included in the study analysis.
Observations & Results: In present study, the incidence of heart diseasewas 0.53%, maximum cases 38.6% were from age-group of ≥25-29 years. 51.3% cases were reported from rural area and 41.9% belonged to upper lower class. 93.6% were booked. 51.3% of cases were having Class II of NYHA classification. The most common heart disease was rheumatic 101(53.4%) followed by congenital heart disease i.e 84(44.4%).Among congenital cardiac lesion the most common was ASD 36(42.9%). InRheumatic cardiac lesion the most common was Mitral stenosis 65(64.3%). Maternal mortality was reported in 05(2.6%) cases, causes of mortality were due to CCF in 3(1.6%) and pulmonary Embolism Sec to RHD and Left Ventricular Failure in CHD in Severe Pre-enclampsia. 01(0.5%)
Conclusion: This study concluded that pre-pregnancy diagnosis, counselling, appropriate referral, routine antenatal supervision and delivery at an equipped centre improve the pregnancy with heart disease outcome for both mother and baby. The study also observed the improved maternal and fetal outcomes in women who had undergone corrective cardiac surgeries before the pregnancy.

Background: Bilirubin is a metabolic byproduct of the breakdown of hemoglobin degradation which itself must be metabolized for appropriate excretion. High levels of bilirubin are associated with decreased risk of coronary heart disease (CHD) and cardiovascular disease (CVD).
Objectives: To study the level is to see correlation between serum bilirubin level and Risk factor of cardiac disease in patients admitted in hospital.
Methodology:  This study includes 100 Male Indian subjects between 35 to 60 years of age who visited medicine OPD of our institute. Biochemical test like Lipid profile, Serum bilirubin and blood sugar(Fasting & Post Prandial) were measured on a fully automatedanalyzer along with quality control sera. Obtained Results were analyzed statistically to calculate p value and to see the difference of significance.
Results: HDL level between OPDand IPD (31.92 ± 4.25 mg/dl and 49.92 ± 7.23 mg/dl ) subjects respectively. In the same manner this table also showed a higher level of FBS 122.23±4.2 mg/dl and PP2BS 132.23±8.0 mg/dl in OPD subjects as compared to IPD patients but the difference among them was not significant. It was represented that the OPD subjects were more prone to risk of CVD because the level of S.choletserol was 220.92 ± 40.21 as compared to 209.45 ± 29.90 in IPD subjects.(p value:<0.001 significant)Regarding serum Triglyceride level , there is no such significant difference found among two group. While comparing the level of serum LDL it was 164.64±15.29 and 134.83±10.39 in Control and case Group Respectively.(p <0.001). The Level of Total bilirubin was 0.84±0.41 mg/dl in control group and 4.42±3.1 in case Group and difference among them was highly significant.
Conclusions: From my study it will be conclude that there is a significant negative relationship was demonstrated between baseline bilirubin levels and incident CHD and CVD death and the level of serum bilirubin is important parameter for defining risk of cardiovascular disease.