European Journal of Molecular & Clinical Medicine

Background: Dentine hypersensitivity is a common complaint among dental patients.
Recently, a novel stabilized calcium sucrose phosphate dentifrice was introduced that offers a
desensitizing benefit. The primary aim of this study was to compare the in vivo efficacy of
this novel dentifrice with Calcium sodium phosphosilicate and a non-desensitizing dentifrice,
on dentin hypersensitivity in a four-week period.
Methods: Sixty volunteers with tooth sensitivity were recruited, and a double-blind,
randomized, parallel, controlled clinical trial was conducted in a hospital setting. Clinical
evaluation for dentin hypersensitivity by 0-10 VAS score was done using air blast, and cold
water methods. Following baseline measures, subjects were randomly divided into three
groups and treated as follows:
Group A: Dentifrice containing calcium sodium phosphosilicate (NovaMin).
Group B: Dentifrice containing Calcium sucrose phosphate.
Group C: Dentifrice containing no desensitizing ingredients. Clinical evaluations were
repeated after two and four weeks of product use.
Statistical analysis used: Mean VAS scores were compared among groups at different time
points (baseline, and 2 and 4 weeks) and among groups at each time point using one-way
analysis of variance.
Results: Compared to baseline, there was a clinically significant decrease in dentin
hypersensitivity in Groups A and B following four weeks use of the dentifrices containing
calcium sodium phosphosilicate and calcium sucrose phosphate, respectively. The Group A
dentifrice, however, was found to be significantly better in reducing the VAS score compared
to the Group B and Group C dentifrice at any time point for both measures of sensitivity.
Conclusion: The results suggest that the dentifrice containing 5% NovaMin provides rapid
and significantly more relief from dentin hypersensitivity in four weeks compared to a
dentifrice containing calcium sucrose phosphate or a non-desensitizing dentifrice.