European Journal of Molecular & Clinical Medicine

Background: Sepsis is a disease characterized by rapid disease process advancement
needing immediate therapy adjustments. Assessment of disease severity is vital for
appropriate disease management, preventing and decreasing the incidence of complications,
decreasing mortality rates, and attaining a better prognosis.
Aims: The present study was conducted to assess laboratory and clinical parameters in
subjects with severe septic shock and sepsis. Also, the study assessed Acute Physiology and
Chronic Health Evaluation-II score (APACHE-II) with Echocardiographic evaluation of
cardiac functions. Cardiac biomarkers including creatine phosphokinase myocardial band
(CPK-MB)and Troponin-T were also assessed in the present study.
Materials and Methods: The present prospective clinical study was conducted to assess the
cardiac biomarkers, clinical, and laboratory parameters in subjects with severe septic shock
and sepsis.
Result: It was seen that significant mortality was seen in subjects with positive Troponin-T
and high CPK-MB levels. In subjects with septic shock and sepsis, CPK-MB levels were
raised. Increased levels of CPK-MB and Troponin-T were also indicative of myocardial
injury which could lead to coronary insufficiency in subjects with septic shock and sepsis.
Conclusion: The present study concludes that in critically ill subjects, levels of Troponin are
usually raised. However, more data is needed to prove prognostic and diagnostic significance
with its implications in subjects with septic shock and sepsis.