Online ISSN: 2515-8260

Keywords : PIVKA


THE 3 REGIMENS OF VITAMIN K1PROPHYLAXIS AT BIRTH: CLINICAL PROFILE

Dr.Giridhar Sethuraman,Dr.Charanraj Honnalli, Dr.Preeti Amarkhed,Dr.K. Srinivasan

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1973-1977

Classical VKDB "occurs between 24 hours and 7days of life and is associated with insufficient stores at birth and delayed or insufficient feeding. The clinical presentation is often mild, with bruises, gastrointestinal blood loss or bleeding from the umbilicus and puncture sites. Blood loss can, however, be significant, and intracranial haemorrhage, although rare, has been described. Considering the smaller sample size, to avoid unequal group sizes, block randomization method was used to allocate the study participants to treatment groups. The block size used was 9, with 3 subjects randomized to each of the three treatment groups, within each block. The median cord PIVKA value on day 5 was 0.0, 0.180 and 0.4 among the intervention groups of A,B and C respectively. The difference in the median PIVKA values across the three intervention groups was statistically not significant (p value 0.346). When presented as binary variable, the proportion of subjects with abnormal PIVKA values was 0%, 3.85% and 8% respectively among intervention group A, B and C respectively.