Online ISSN: 2515-8260

Keywords : Dry eyes


Assessment of prevalence of dry eye diseases in diabetic patients

Dr.Shreyanshi Sharma, Dr.SushilOjha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 1581-1585

Background:Diabetic patients might exhibit dry eye symptoms probably due to neuropathy,
metabolic dysfunction, or abnormal lacrimal secretions. The present study was conducted
to assess prevalence of dry eye diseases in diabetic patients.
Materials & Methods:92 diabetic patients of both genders were enrolled. Ocular
examinations, fasting blood sugar (FBS), postprandial blood sugar, and glycosylated
hemoglobin estimation (HbA1c) were recorded. Dry eye patient was diagnosed with the
help of slit-lamp examination, Schirmer’s test, tear film break-up time (BUT), and Rose
Bengal staining technique. Gradation of dry eye was done by the following standard
protocol.
Results: Dry eye was present in 70 and negative in 22. The mean duration of diabetes was
11.4 years in positive cases and 5.6 years in negative cases. The difference was significant
(P< 0.05).Grade was mild in 32, moderate in 20 and severe in 18 patients. The difference
was significant (P< 0.05). Age group (years)<50 years had 24, 50-60 years had 30 and >60
years comprised of 16 patients. Blood sugarcontrol (HbA1c) was good in 12, fair in 10,
action suggested in 28 and poor in 20 patients. The difference was significant (P< 0.05).
Conclusion: There was high prevalence of dry eyes in diabetic patients. Grade of dry eyes
was mild, moderate and severe.

A comparative study of preserved and preservative-free hydroxypropyl methylcellulose-dextran-containing eyedrops in dry eye disease

Dr. Laxman Kumar, Dr Pankaj Kumar, Dr Awadhesh Kumar Jha

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1868-1871

Background:Dry eye is a disorder of the tear film which occurs due to tear deficiency or
excessive tear evaporation. The present study compared preserved and preservative-free
hydroxypropyl methylcellulose-dextran-containing eyedrops.
Materials & Methods: 56 patients of dry eyes disease were divided into 2 groups of 28 each.
Group I were prescribed dextran 70, 1 mg/ml and hypromellose, 3 mg/ml hydroxypropyl
methylcellulose (HPMC) and group II 0.3 g HPMC and 0.1 g of dextran 70, with 0.01%
benzalkonium chloride (BAK). The ocular surface disease index (OSDI) questionnaire, tear
break up time (TBUT), corneal and conjunctival staining and Schirmer test were performed.
Results: The mean OSDI score at baseline was 42.6 and 39.4 and at 4 weeks was 32.7 and
28.1 in group I and II respectively, TBUT (sec) at baseline was 7.6 and7.4 and at 4 weeks
was 7.1 and 8.1 in group I and II respectively, conjunctival score at baseline was 6.78 and
7.32 and at 4 weeks was 5.30 and 5.4 in group I and II respectively, corneal score at baseline
was 1.47 and 1.24 and at 4 weeks was 0.52 and 0.41 in group I and II respectively and
schirmer test (mm) at baseline was 6.07 and 6.12 and at 4 weeks was 6.80 and 7.25 in group I
and II respectively. The difference was significant (P< 0.05).
Conclusion: Both preserved and preservative-free hydroxypropyl methylcellulose-dextrancontaining
eyedrops were effective in reducing symptoms of dry eyes disease.