Online ISSN: 2515-8260

Keywords : Rheumatoid Arthritis


Analysis of Hematological Abnormalities associated with Rheumatoid Arthritis Patients at a Tertiary Care Centre

Manish Mittal; Deepak Verma

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 5, Pages 489-493

Introduction: Rheumatoid arthritis (RA) is a systemic inflammatory disorder associated with significant proportion of haematological abnormalities. The present study was undertaken for assessing the haematological abnormalities among rheumatoid arthritis patients. The main aim of the study is to study the prevalence of haematological manifestations in patients with seropositive rheumatoid arthritis.

A cross-sectional study to assess correlation of electrocardiographic abnormalities and echocardiographic findings in rheumatoid arthritis patients in Western Rajasthan

Narendra Choudhary, Mohammad Yaseen, Kishore Singh Choudhary, Veeram Parmar, Arvind Kumar Jain

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3385-3395

Background: Rheumatoid arthritis (RA) is a chronic multi system disease of unknown cause. The most frequent site of cardiac involvement in RA is the pericardium.  Cardiac disease is clinically silent and is rarely a life-threatening complication in RA. Cardiac failure is the result of either systolic or diastolic dysfunction, or both. Hence this study was conducted to study correlation of electrocardiographic abnormalities and echocardiographic findings in rheumatoid arthritis patients without clinically evident cardiovascular manifestations with the duration of disease.
Methodology: The Hospital based cross sectional observational study was conducted on 50 patients, above 20 years attending the medicine outpatient department of Dr. S.N. Medical College and Mathura Das Mathur Hospital Jodhpur with an established diagnosis of RA, as defined by the ACR/EULAR criteria for Rheumatoid arthritis. A questionnaire was prepared and investigations were performed.
Results: Cardiovascular manifestations are common in Rheumatoid arthritis patients. This study highlights the need for systematic electrocardiogram in patients with rheumatoid arthritis, even in the early stages of the disease when cardiovascular involvement is clinically silent because electrocardiographic abnormalities are real and should alarm the physician and lead to the initiation of appropriate therapy that may help reduce the incidence of cardiovascular death in RA patients. The relation between transmitral flow alteration and disease duration suggests a sub-clinical myocardial involvement with disease progression and may be related to the high incidence of cardiovascular deaths in patients with RA

HAEMATOLOGICAL ABNORMALITIES ASSOCIATED WITH RHEUMATOID ARTHRITIS PATIENTS

Ankush Kimmatkar, Olanrewaju Adeniran, Aishwarya Ashok Kimmatkar, Rasha Al-Hashimi, Ngumimi Peace Kpughur-tule, Sagimaie Somasundaram, Vivian Samuel Hana, Taha Sajjad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3023-3028

Background: The present study was undertaken for assessing the haematological disorders among patients presenting with rheumatoid arthritis.
Materials & methods: 100 consecutive rheumatoid arthritis patients were enrolled. Only patients aged 18 years or more willing to participate in the study were included. Also; inclusion criteria included patients having joint pains, signs of inflammation, involving mono or polyarticular joints. A detailed history of the patient was taken and through clinical examination was done according to predesigned and pretested proforma. All patients were subjected to investigations like: Complete Haemogram, ESR, RBS, Blood Urea, Serum Creatinine, Electrocardiogram, Echocardiography and Radiography of Affected Joints. The descriptive and analytical statistics was done
Results: Anaemia was found to be present in 67 percent of the patients. Leucocytosis and thrombocytosis were found to be present in 21 percent and 33 percent of the patients respectively. Raised ESR and raised CRP were found to be present in 94 and 95 percent of the patients.  Anti-CPP was found to be present in 100 percent of the patients.
Conclusion: Specific results may help to target patient education, increase physician awareness of the profile of the disease and suggest the need for social and rehabilitative services, and help monitor responses to therapy.

Vitamin D status and its association with disease activity in early rheumatoid arthritis in rural population of central India

Granth Kumar, Vidya Sagar Ram,Pankaj Kumar, Amit Varshney

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 648-652

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease
characterized by joint swelling, joint tenderness, and destruction of synovial joints,
leading to severe disability and premature mortality. Early rheumatoid arthritis is
defines as “RA with duration of disease/symptoms of disease < 6 month.”
Aim:To study serum vitamin D level in newly onset rheumatoid arthritis patients.
Methodology: It is a Case-control study, all patients fulfilling revised American College
ofRheumatology criteria/EULAR criteria(2010) for Rheumatoid Arthritis being
attended to in therheumatology clinic, Tools like Oral questionnaire, History &
Clinicalexamination,laboratory equipments will be used.Sample size is 45 cases and 45
controls, complying with inclusion and exclusion criteria.
Result: The study suggested that, mean value of Clinical Disease Activity Index (CDAI)
of RA was 12.24±8.05 in cases and 2.89±0.83 in control, DAS28 Score was 4.24 ± 1.07 in
cases and 3.00 ± 0.37 in control, it showed statistically significant association between
serum Vitamin D3 level with CDAI and DAS28 Score in rheumatoid arthritis patients.
Conclusion: The study results suggest that the inverse relationship between serum
Vitamin D levels and RA disease activity.

A REVIEW ARTICLE ON RHEUMATOID ARTHRITIS: PATIENT EDUCATION

Neha Singh, Bhupendra Kumar,Gupta Anjan, Amandeep Baghla

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 734-744

Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic autoimmune disease, affecting
the joints with varying severity among patients. The risk factors include age, gender, genetics,
and environmental exposure (cigarette smoking, air pollutants, and occupational). Many
complications can follow, such as permanent joint damage requiring arthroplasty, rheumatoid
vasculitis, and Felty syndrome requiring splenectomy if it remains unaddressed. As there is no
cure for RA, the treatment goals are to reduce the pain and stop/slow further damage. Here, we
present a brief summary of various past and present treatment modalities to address the
complications associated with RA.

Effects of laser therapy versus laser acupuncture on rheumatoid arthritis elderly patients

Afnan Sedky Adly; Zahra M. Serry; Mohamed Shehata; Mohamed Amr; Heba Ahmed Ali Abdeen

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 2717-2725
DOI: 10.31838/ejmcm.08.03.316

Objective
Rheumatoid arthritis (RA) is regarded as the commonest and one of most known
inflammatory arthritis. Our study was to determine the effects of laser therapy and laser
acupuncture therapy on RA elderly patients.
Subjects and Methods
Forty patients with age of 65 to 75 years were being randomly allocated to 2 groups. Group(A)
included twenty participants having RA treated via low level laser therapy. Group(B) included
twenty participants having RA treated via laser acupuncture. All the patients underwent
treatment by methotrexate. Treatments were provided three times each week to the two groups
for twelve weeks.Independent laboratory technician and statistician were blinded to the study
groups.

Study of Rheumatoid Arthritis Patients with Foot Disorders and Deformities Occurrence

Eman E. Elshahawy; Amany R. El Najjar; Ibrahim Tharwat AbdElal; Salma Gamal Mohammed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2659-2671

Background: The most prevalent form of inflammatory arthritis is rheumatoid arthritis (RA) and it usually involves elbows, feet, wrists, knees, and ankles. The foot is the first region of the body to display RA signs and symptoms for certain patients. This research aimed to assess the prevalence of foot disorders in RA patients, identifying the relationship between the activity of the RA disease and foot disorders, as well as their effect and deformities occurrence.
Patients and methods: A total of 300 RA patients were included in this report. There were 240 women and 60 men, aged between 18 and 74. The following were done to all patients: complete historical review, complete clinical examination, and the evaluation of disease occurrence Complete blood count (CBC), Erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), rheumatoid factor (RF) titer, and anti-cyclic citrullinated peptide (anti-CCP Ab) titer were used and X Ray on foot done to all patients
Results: We found that 31.6% of the study patients had foot deformities. 214 patients (71.3%) had normal gait while 86 patients (28.7.0%) had pathological gait. Hallux valgus was common among old age and obese RA patients. The foot deformities are associated with moderate and high DAS28 activity. Obese RA patients are more susceptible to have foot problems 2.89 times more than normal-weight RA patients. 176 patients (58.6%) had narrowing, 97 patients (32.33%) had osteoporosis 87 patients (29.0%) had erosion, 20 patients (6.67%) had bone cyst, 17 patients (5.6%) had subluxation and 14 patients (4.6%) had amalgamation.

Impact of sex hormone fluctuations on functional health status and menopause rating scale among postmenopausal RA patients

Essam Tawfik Atwa; Hisham Mohamed Omar; Asmaa Amin Mohamed

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2390-2400

Introduction: Women with RA have higher grades of disease activity and more declines in health status than men with RA; this recommends a relationship between estrogen and disease activity and severity.
Aim: Our aim was to detect the effect of sex hormone fluctuations and menopause on functional disability and quality of life of postmenopausal RA patients.

Type of article: Review article Title of the article: SJOGREN’S SYNDROME IN DENTIST PERSPECTIVE- A REVIEW

Dr. G. Nishanth; Dr. N. Anitha; Dr. N. Aravindha Babu; Dr. K.M.K. Masthan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 4, Pages 1495-1498

Sjogren’s syndrome (SS) is an autoimmune disorder which is responsible for glandular dysfunction most preferably salivary and lacrimal glands, caused mainly by the lymphocytic infiltration of exocrine glands. It can be classified into two, namely Primary Sjogren’s syndrome and Secondary Sjogren’s syndrome. Primary Sjogren’s syndrome (pSS) occurs in the absence of other autoimmune diseases and is characterised by keratoconjunctiva sicca (dry eyes) and xerostomia (dry mouth), collectively called the sicca syndrome. On the other hand, secondary Sjogren’s syndrome is associated with other autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The prevalence of SS is estimated to be approximately 3% in subjects 50 years or older, with a female to male ratio of 9:1. Conditions associated with SS include rheumatoid arthritis, lupus erythematosus and scleroderma. The clinical manifestations are often vague and mistakenly interpreted and attributed to other medical conditions or iatrogenic disorders. As such, incorrect diagnosis of SS is common and approximately half of all patients are thought to be undiagnosed

“Effectiveness Of Structured Teaching Programme On Knowledge Regarding Adverse Effects Of Tobacco Usage Among B.Sc Nursing Students Of Sree Balaji College Of Nursing, Chrompet – Chennai”

Yerram Sai Rama Krishna Reddy

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 6075-6079

Smoking leads to disease and disability and harms nearly every organ of the body. Smoking causes cancer, heart disease, stroke, lung diseases, diabetes, and chronic obstructive pulmonary disease (COPD), which includes emphysema and chronic bronchitis. It increases risk for tuberculosis, certain eye diseases, and problems of the immune system, including rheumatoid arthritis. Secondhand smokers are also at great risk of developing certain disease conditions like stroke, lung cancer, and coronary heart disease in adults.

Carbon Nanotubes In Treatment Of Arthritis: An Overview

Manvendra Singh; Pallavi Nayak; Vijay Mishra

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4366-4372

Arthritis is a type of joint dysfunction that includes one or more joint inflammation like rheumatoid or psoriatic arthritis, and associated autoimmune disorders. The biggest concern about arthritis is that the discomfort is always persistent and may be confined to the injured joint due to swelling that happens throughout the joint, trauma to the joint induced by illness, regular wear and tear, muscle strains triggered by vigorous action toward hard sore joints and exhaustion, which in effect contributes to inflexibility, immobility and muscle weakening. Carbon nanotubes with unusual physicochemical properties (cell membrane penetration, large surface area and drug payload, biocompatibility, simple surface alteration, photoluminescence properties and non-immunogenicity) are employed to conquer the challenges of inflammation.

DYSLIPIDEMIA AND WAYS OF ITS CORRECTION IN RHEUMATOID ARTHRITIS PATIENTS WITH METHOTREXATE TREATMENT

Sevara Mukhammadieva; Elnora Djuraeva; Nargiza Abduazizova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2439-2449

patients under 30. The control group consisted of 110 healthy middle-aged
individuals. In the surveyed population, those with 1 to 5 years of age were the largest group
(38.3%), followed by those with 5 to 10 years of age (34%). In 66.3% of the patients of RA MT
was used as a base preparation. The average dose (median) of MT over the study period was
10 mg per week. 80% of patients took prednisolone in an average dose of 10 mg/day. The
content of lipids in venous blood was determined by photocolometry on Vitros SYSTEM
Chemistry DT 60 biochemical analyzer (Austria). Results: RA patients who took MT showed a
significant increase in the level of triglycerides (TG). Also, it is characterised by an increase
in TG levels and a decrease in the concentration of high-density lipoprotein cholesterol
(HDL) and an increase in the atherogenicity factor. A more pronounced decrease in HDL
levels. Significantly high indicators of the atherogenicity coefficient, which to a lesser extent
depended on the duration of MT use. Low-density lipoprotein cholesterol (LDL) and
triglyceridemia are also proved to be serious risk factors for atherosclerosis and
cardiovascular heart diseases (CHD). Also according to the results of the research, special
attention is paid to the use of hypolipidemic drugs, which is promising in improving the
prognosis and reducing cardiovascular injuries in RA patients. In the group of patients who
received additional lipidex SR, there was a decrease in the level of OHS by 17.1%, an
important shift was observed on the part of TG, this indicator decreased by 29.7% and
practically did not differ from the control indicators. HDL cholesterol in the SR lipidex group
increased significantly by 37.7%. These fibrates have a stimulating effect on all components of