Online ISSN: 2515-8260

Keywords : Oxytocin



European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 5560-5569

Background:Pre-emptive analgesia is an anti-nociceptive intervention given before incision
which helps to reduce pain sensitization to transmission of pain signals evoked by tissue
damage.Oxytocin has recently been recognized as an important mediator of endogenous
analgesia. The present study aimed to assess the effectiveness of preemptive port site
subcutaneous oxytocin infiltration in reducing post-operative pain as compared to post-operative
infiltration in patients undergoing laparoscopic surgeries.

Comparision of Progression of Labour and Fetomaternal Outcome Between Spontaneous and Induced Labour

Kesavachandra Gunakala, P.M.Rekha Rao, Mude Vennela, Haneesha M.S

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 6045-6051

Background:Induction of labour is artificial initiation of uterine contractions prior to
spontaneous onset leading to progressive dilatation and effacement of cervix. Induction
of labour process whether by administering foley bulb induction, stripping, oxytocin
(or) prostaglandin. Labour induction is indicated where the benefits of either the
mother or fetus outweighs the benefit of continuing pregnancy. Aims and Objective:
The aim of the study is to analyze the progression of labour and comparison of fetal and
maternal outcome between spontaneous and induced labour.
Materials and Methods: Present study is a prospective comparative study involving 200
participants divided into induction (study) and spontaneous (control) groups. Data was
collected on socio demographic factors, maternal complications and fetal outcome
.Those women who had spontaneous onset of labour and reached >4cm of cervix
dilatation were included in study group. Progress of labour is monitored by modified
WHO partographs. Women on induction reached >4cm dilatation of cervix were
included in control group. Informed consent taken from every participant in the study.
Results: In the study group, the mean duration of active phase in primigravida was
6.2hours and in multigravida was 3.7hours. In control group, the mean duration of
active phase in primigravida was 4.7hours and in multigravida was 2.5hours.In study
group, the duration of second stage in primigravida and multigravida was 46minutes
and 25minutes respectively whereas in control group, it is 40 minutes for primigravida
and 21 minutes for multigravida. Induced labour is associated with higher cesarean
section rates. Cephalopelvic disproportion was the most common indication for
cesarean section followed by failed induction.
Conclusion: The mean duration of active phase and second stage of labour is longer in
study group compared to control group. Neonatal outcome was similar in both groups
except for 1minute and 5-minute APGAR scores which were significantly higher in
spontaneous group. Augmentation of labour is frequently required in study group
rather than control group. Occurrence of maternal complications like PPH, fever,
vomiting and hyperstimulation of uterus showed no significant difference in both the

A prospective comparation of outcome of labour induction with vaginal misoprostol and intravenous oxytocin in term pre-labour rupture of membranes

Priyadharshini Durairaju, Pritamkumar Singh

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2100-2104

Aim and Objectives: The aim of the present study was to assess the safety and efficacy of vaginally administered misoprostol 25mg with intravenous oxytocin for labor induction in term prelabour rupture of membranes.
The subjects with rupture of membranes without labor were assigned to receive either vaginally administered misoprostol 25 micrograms or intravenous oxytocin infusion this prospective study was conducted during February 2014 to January 2016 in the Department of Obstetrics and Gynecology of Regional Institute of Medical Sciences, Imphal, India.
Results and Observation: Of the 192 subjects 96 received intravaginal misoprostol and 96 received intravenous oxytocin It was observed that the average interval from start of induction to delivery was about one hour shorter in misoprostol group (12.58+4.08 hours vs 14.00+3.31 hrs) than in oxytocin group (P=0.05). Vaginal delivery occurred in 82 misoprostol treated group and in 80 oxytocin treated group (85.4% vs 83.3%, P= 0.691).Caesarean section was done in 14 of misoprostol treated subjects and in 16 oxytocin treated subjects (14.6% vs 16.7%) which is not statistically significant.
Conclusion: Vaginal administration of misoprostol is an effective alternative to oxytocin infusion for labor induction in women with prelabour rupture of the membranes at term.

A Comparative Observational Study of Oxytocin Bolus and Oxytocin Infusion During Caesarean Section

Vege Vishnu Santhi, Sajana Gogineni, K.B. Gayathri

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11662-11673

Background:To assess the statistically significant effects in the oxytocin bolus and infusion to decrease caesarean section postpartum haemorrhage.Postpartum haemorrhage (PPH) during Caesarean section is one of the most common causes of maternal death throughout the world > 72% in India. Although the value of routine oxytocics to reduce postpartum haemorrhage after vaginal birth has been well established, their value in caesarean section has received little attention. The present Prospective observational cross-sectional study is an attempt to compare the efficacy of intravenous oxytocin bolus dose followed by infusion and only intravenous oxytocin infusion following delivery of fetus in elective and emergency LSCS with regard to their influence on various parameters to prevention of postpartum haemorrhage
Materials and Methods: Present study was done at Department of Obestetrics & Gynecology,Dr. PSIMS &RF, Vijayawada, Andhra Pradesh, India and analysed the efficacy of intravenous oxytocin bolus followed by infusion and only intravenous oxytocin infusion on uterine tone, alterations in mean arterial pressure (MAP), alterations in heart rate (HR), blood loss by difference in hemoglobin and hematocrit, need for additional oxytocin and side effects of the drugs, if any in 350 low risk patients scheduled to undergo elective and emergency lower segment caesarean section under spinal anesthesia during the a period of September 2020 to April 2022.
Results: The average decline in hemoglobin was prevalent in group B with 4.51+/-0.1gm%. than in group A 3.69+/-1.28gm%. There was a homologous simultaneous decrease in PCV by16.42 +/- 3.1 in group B than in group A 13.25+/-1.46, which was statistically significant. There were fall in Hemoglobin and PCV in both the groups. There were improvements in uterine tone by 25th minute in both groups as compared to 5th minute. All patients in Group A and B had adequate to well contracted uterus.
Conclusion: It is concluded from this study that oxytocin intravenous bolus can be given in cases where atonic PPH is expected like, multifetal gestation, polyhydromnios, big baby, prolonged labour, obstructed labour.

The Efficacy of Intrauterine Misoprostol during Cesarean section Plus intravenous Oxytocin In Prevention Of primary postpartum Hemorrhage (PPH)

LubnaAmmer El-Hammroni, Ali El-Shabrawy Ali, WaelSabryNossair, Safaa Abdel-Salam Ibrahim

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2809-2819

Background:The misoprostol tablet is very soluble and can be dissolved in 20
minutes when it is put under the tongue a pharmacokinetic study compared the
absorption kinetics of oral, vaginal and sublingual routes of administration of
misoprostol found that sublingual misoprostol has the shortest time to peak
concentration, the highest peak concentration and the greatest bioavailability when
compared to other routes.The aim of the present study was to to improve the
management primary postpartum hemorrhage during and after elective cesarean
section (CS). Patients and methods:This study was carried out on 46 cases admitted
for elective CS at University Hospital. They divided into two groups regarding the
protocol of treatment, was given oxytocin, 10 IU in 250 ml of Normal saline
solution over 10 minutes was administered directly after opening the
uterus.Misoprostol group was given 400 mcg misoprostol plus intra venous
Oxytocin administered directly after opening the uterus. Results: There was
statistical significantly between the two studied groups in hemoglobin and HCT
postoperatively with higher level among intra venous oxytocin plus intra uterine
misoprostol than intra venous oxytocin only group. But regarding preoperative
hemoglobin and HCT, there was no statistically significant difference before and
after treatment. Higher blood loss either intraoperative, postoperative and overall
blood loss on intra venous oxytocin only group than intra venous oxytocin plus
intra uterine misoprostol.There was statistical significantly decrease in both
hemoglobin and HCT postoperatively in the two studied groups but this decrease was
more among intra venous oxytocin only group than intra venous oxytocin plus intra
uterine misoprostol. Conclusion:Intrauterine misoprostol combined with oxytocin
infusion during caesarean section can minimise intraoperative blood loss, avoid
postpartum haemorrhage, and reduce any additional uterotonic medication