Online ISSN: 2515-8260

Keywords : Patients


Need Assessment on Patients with Advanced Stage Cancer

Maria Komariah; Laili Rahayuwati; Nita fitria; Henny Yulianita; Valentina B.M. Lumbantobing

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 974-985

Need assessment is one of the important steps that should be conducted to be able to provide health care to patients with advance stage cancer because by understanding the needs of the patient, an appropriate and proper care can be provided. Inadequate efforts to\meet the needs of patients will affect their quality of life and their satisfaction towards health care. This descriptive study uses Needs Assessment for Advanced Cancer patients (NA-ACP) questionnaire to describe the patient needs based on seven main need domains of advanced cancer patients as well as several additional needs. The results of this study show that the three most needed domains (100%) by advanced cancer patients are medical  information and communication, psychological/emotional support and other needs. Meanwhile, the most frequently felt need, i.e. from moderate to high, (98%) is other needs. Based on those results, it is recommended that hospitals and health care workers should pay more attention to the advanced cancer patients, especially the need for medical information and communication, psychological/emotional needs, financial need, and other needs. To address the issue, training on communication can be provided to health care workers, health education can be given to patients through picture/video media, palliative care counseling unit and cancer support group can also be established. In addition, a clear information media on how to access financial support available for the patients should also be provided.

BKV infection in cancer patients presenting with cystitis

Vian Ibraheem Husain; Salah Mahdi Hassen; Amal Aziz Kareem

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 1, Pages 1433-1439

Objectives: In this study we aimed to determine the incidence of BKV infection in patients undergoing chemotherapy for different types of cancer who present with cystitis. This study provides molecular evidence of a possible association between BKV and cystitis in cancer patient treated with chemotherapy. Materials and Methods: The study was performed on urine samples from 85 individuals (45 cancer patients during an episode of cystitis and compared with that detected in the urine of 20 cancer patients with no cystitis and 20 healthy individuals) in order to better evaluate the association of BK virus reactivation with cystitis. Detection of BKV in urine by real time PCR assay was done for all of the three groups. Results: Results on the detection of viral DNA from the urine samples demonstrated that 4 (8.89%) of cancer patients with cystitis, in 1 (5.00%) of cancer patients with no cystitis, while 3 (15.00%) of healthy controls, were positive. Recommendations:Our findings merit more studies to be done in a larger number of patients including multiple centers to help in establishing a causal association.

STUDY CORRELATION BETWEEN SOME IMMUNE MARKER in PATIENTS with LICHEN PLANUS

MUNA AHMED ABDULLAH

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 400-407

Lichen planus is an autoimmune disorder that primarily affects the body's skin and
multiple mucous membranes. In multicellular species, protein 53 and syndecan-1protein
play an significant role since they control the cell cycle and thus play a major role in
tumor suppression and cancer prevention. The p53 gene was therefore identified as a
"genome protector," referring to its role in preserving the integrity of genetic
information by preventing gene mutations. The purpose of this analysis was to study the
association between certain immune markers in lichen planus patients.
The aim of this study : Study correlation between some immune marker in patients with
lichen planus
Methods 'Thirty formalin-fixed , paraffin-embedded tissue pieces, diagnosed as Oral
Lichen planus(OLP), were included in the sample of this report.
Results: Evaluation of P53 Immunohistochemistry and Evaluation of syndecan-
1protein Immunohistochemistry Conclusion: the marker p53 expression is high in the
patient with Lichen Planus while the second studed marker syndecan-1 protein is less
than marker p53

HBV Genotyping distribution among Iraqi patients in Wasit Province

Sabreen Hadi Hanash; Kareem Hamed Ghali; Ahmed Darwish Jabbar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4263-4278

Hepatitis B viruses are one of the world's most important issues for public health. HBV production is driven by this high mutation rate which results in a high degree of genetic heterogeneity with a distinct geographic distribution of 10 resulting genotypes (A – J) .This study aimed to determination the HBV genotypes distribution among Iraqi hepatitis B virus patients.The study included 100 patientswith positive HBs Ag .Muliplex PCR results showed thatthe percentage of HBV genotypes distributed among patients was as follows: AE 1%, ACD 1% , ABCDEF 1% , ABCDFG 1% , B pure 30%, BC 9% , BD 1%, BE 3% , BF 1%, BCE 6% , BCDE 1%, BCDF 1%, BCEF 1%, C pure 16%, CD 13%, CE7%, CDE 2%, D pure 4%, E pure 1%, so the most common genotype is B pure genotype (30%) , and in the second rank C genotype (16%), however the C mixture genotype was (59%) was common followed by B genotype (55%) .Based on our knowledge this study is the first study in Iraq that documented genotype G in one sample.

Modern Approaches To Vitiligo Treatment

Mukhabbatkhon Yokubova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 1005-1007

This article discusses modern approaches to treating vitiligo and lists the methods of treating vitiligo.It was used to treat vitiligo in 28 patients. Most of them enjoyed of clinical condition. The preparation was well tolerated and produced no adverse effects.

COVID-19 care options: Facts and Challenges

Dr.Nandhana Prashanth V; Dr.Ravikanth P

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5694-5700

In December 2019, an outbreak due to extreme acute Coronavirus 2 (SARS-Cow-2) respiratory syndrome was first identified in Wuhan, China. The 2019 global coronavirus disease (COVID-19) pandemic in 2020 culminated in an extraordinarily strong risk for spreading. No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp). No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp). No medications in large-scale trials have been validated with substantial effectiveness of clinical care for COVID-19 patients considering the declining pattern of COVID-19. Remdesivir is deemed the most promising antiviral agent; it acts by inhibiting RNA-dependent polymerase RNA function (RdRp).

Clinical And Functional Predictors Of The Development Of Acute Ischemic Stroke In Patients With Acute Myocardial Infarction

Sidika K Shadmanova; Dilbar T. Khodjieva; Khaydarova D. Kadirovna

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 5784-5787

The complexity of diagnosis in the case of a combination of myocardial infarction and stroke is associated with the prevalence of cerebral symptoms more often; success in this case depends on the rational use of modern diagnostic methods with stratification of risk factors, which allows choosing the optimal tactics for the treatment and prevention of cerebral and cardiac complications. Timely recognition of cases of a combination of stroke and myocardial infarction is extremely important, which underlines the need for further research

Dance and Music as a Therapy to Heal Physical and Psychological Pain: An Analytical Study of COVID-19 Patients during Quarantine

A. Cineka; J.Michael Raj

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 99-109

This paper delineates that involvement to dance and music is an active therapy that offers physical and psychological benefits for the people who affected with diseases. It is closely connected with human emotions which reduce the psychological pain and depression of people when they are getting involved with music and dance. Due to the outbreak of Coronavirus disease (COVID-19), patients are totally under stress and fear for life and livelihood. To overcome this perilous situation, involvement to dance and music is suggested to be an apt therapy that fights against the psychological and emotional effects through its unique power. Involvement to dance and music serves as a useful vehicle of hope and positivity to patients who are under quarantine. Hence, this paper aims to study the collaborative understanding of COVID-19 patients’ perspectives on the involvement to dance and music and how it relieves their psychological pain and gains their physical strength while diverting them from fear to during quarantine. There are 215 COVID-19 patients taken as subjects from Tamilnadu, India. There were ten questionnaires used to collect the data through Google forms. The data was analyzed through ANOVA calculation. The major finding of the study indicates that involvement to dance and music brings immeasurable healing to body and mind. Furthermore, this study recommends dance and music to be used as a therapy for COVID-19patients all over the world to keep them healthy and positive.

The Influence Of Doctors And Patients’ Perception On The Drugs Availability In The Hospital During The Era Of National Health Insurance

Satibi Satibi; Pratiwi Ayu Dritani; Dwi Yufenita; Septimawanto Dwi Prasetyo

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 148-156

The drug availability is still a problem in the JKN (National Health Coverage) era in Indonesia, this is the role of pharmaceutical industry in support the drugs availability by implementing good supply chain management. The research aims to identify the factors of production planning, production capacity and procurement of raw material in the pharmaceutical industry in support the drugs availability in the JKN era. This research is descriptive study with qualitative methods. This research uses primary data form in-depth interviews with employees at four national pharmaceutical companies that won the e-Catalogue tender as a producer of generic drugs in Jakarta. The sampling in this research is by purposive sampling with 6 key informants on supply chain management. The data was analyzed by interview transcripts, interpretation data and checking the validity of the data by triangulation. Production planning, production capacity and procurement of raw material have an influence on pharmaceutical companies in support the drugs availability. Production planning, production capacity and procurement of raw material have an influence on pharmaceutical companies in supporting drugs availability, because the RKO (drug requirement planning) used as the basis for procurement of drugs in e-Catalogue is inaccurate so the pharmaceutical companies can’t make accurate production planning and quantity of public drugs aren’t right amount, time and aren’t available when needed and procurement of material still depends on imported raw material with lead time 1-3 months so it can be increase of potentially a public drug stock out.

CLINICAL JUSTIFICATION FOR THE USE OF PHYTO TEA "ANTIOXIDANT" IN PATIENTS WITH TOXIC LIVER DAMAGE

KhamrakulovaMukaddaskhon .; AdilovUtkir .; SadikovAskar .; NarkhojaevaShahnoza .; SaginbekovKadirjan .

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2738-2746

Background: The broad development of the chemical industry, the use of
pesticides in agriculture has led to an increase in hepatitis. At the same time,
different substances in their structure can cause liver function failure.
Objective: The objective of this work was to assess the functional state of
the liver of animals poisoned with the pesticide Bagira, using in their diet dishes
made from local food and additional introduction of a complex of local herbal
medicines into the diet.
Methods: The study involved patients with toxic hepatitis who had
industrial contact with chemicals. The total number of patients was 80 males,
aged 35 to 78 years.
Results (Findings): Based on the results of our research, the antioxidant
phyto tea helps to eliminate cytolytic, cholestatic, inflammatory syndrome,
improve the protein-synthetic function of the liver, improve the functional
activity of the liver, remove toxins from the body, maintain the function of
organs and systems. It is a natural, safe, powerful antioxidant.
Conclusions: 1) Studies have shown that patients diagnosed with chronic
hepatitis have disorders of the functional state of the liver, as well as the
gastrointestinal and nervous systems.
2) Change of biochemical indicators indicates a violation of metabolic, proteinsynthetic,
biliary, antitoxic functions of the liver: increase of bilirubin fractions,
the activity of alanine transferase (ALT), AST, the level of alkaline phosphatase,
gamma-glutaminetranspeptidase (GGT) in serum.
3. The use of phyto tea "Antioxidant" in patients with toxic liver damage
contributed to the increase of liver functional activity.

DENTAL FLUOROSIS AMONG PATIENTS VISITING A DENTAL HOSPITAL IN CHENNAI.

Umayal. S; Pradeep Kumar; R Smiline Girija. A.S

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1827-1833

Dental fluorosis is a sign of prolonged high fluoride exposure. The aim of the study is to assess the severity of dental fluorosis among the patients visiting a Dental College in Chennai, Tamilnadu. A retrospective institution based study was conducted by evaluating and analysing 291 patient case records visiting a dental hospital from December(2019) to March(2020) who had signs of dental fluorosis. Data such as age, gender, type of dental fluorosis were documented from the online database of saveetha dental college - DIAS Dental Information Archiving Software. Ethical approval was obtained by the institutional ethical board at Saveetha University. The data was examined by two examiners. The data collected was reviewed and subjected to statistical analysis using IBM SPSS software version 20.0. The present study shows Females and middle aged patients with dental fluorosis visit dental hospitals more frequently.

DETERMINANTS AND PREVALENCE OF DEPRESSION AMONG ELDERLY PATIENTS ATTENDING PRIMARY HEALTH CARE CENTER IN MAKKAH AL-MUKARRAMAH ,2019

Ayman Ibrahim Mzjaji, Jalal Ibrahim Mzjaji, Hossam Hassan Esawi, Ahmad Huwaymid Alowfi, Sultan A. Alhazmi, Suhaib Talal Alsulimani, Salman Fudlaldeen Jan, Turki Moghli Alaslani, Fahad Salem Alsolami

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 150-161

Background:
Psychiatric disorders in Saudi Arabia, mainly depression are estimated to have high prevalence. More than 6 decades ago, the World Health Organization (WHO) defined health as “a complete state of physical, mental and social well-being, and not merely the absence of disease or infirmity.” Bircher, 2005 defined health as “a dynamic state of well-being characterized by a physical and mental potential, which satisfies the demands of life commensurate with age, culture, and personal responsibility”. Health has been defined by various authors, who have always emphasized its mental component.In recent years, there has been a sharp increase in the number of older persons worldwide. Globally, more than 350 million people of all ages suffer from depression. Elderly persons are more vulnerable to depression. By the year 2020 depression would be the second major cause of disability adjusted life years lost, as reported by the World Health Organization. depressive symptoms are common among older people and are associated with disability, morbidity and mortality. Depression is a mental illness which causes persistent low mood, a sense of despair, and has multiple risk factors.
 Aim of the study: To assessment the determinant and prevalence of depression among elderly attendees in primary health Care center in Makkah Al-Mukarramah.
Methods:Methods: A cross-sectional study was conducted among elderly patients attending to clinic in PHC at Makkah, Saudi Arabia, during the October to December, 2019, validated questionnaires concerning demographic data and knowledge scores on depression among elderly. Our total participants were (400). Results:show that the Family history of depression (70.0%) is the most common clinical variables also show that of the(45.0%) participants have negative depression , (23.0%) have moderate depression,  and the data ranged from(0to 16)by mean+ SD (7.254+2.88).
Conclusion:Depression is associated with a deficiency in the cognitive state, with familial partner risk being an influential factor that may be preventable. Depression constitutes a health problem among Saudi geriatrics in in Makkah Al-Mukarramah, especially among elderly, those having history of chronic diseases and those having sensory impairment. These results provide insight for all health care workers caring for the elderly, researchers in the field of Geriatrics, and health educators into the particular care needs of elderly patients in Makkah, KSA.

Assessment of Health Related Quality of Life among Patients Smoking attitudes attending Primary Health Care Centers in Makkah, Saudi Arabia (2019)

Saud Abdulhai Gari, Muhammed Musa Yahya Sufyani, Hisham Ali Abdo Ali, Amna Mahmoud Ibrahim Altakroni, Ahmed Abdul Rhman Ahmed ALQarni, Mazin Ibrahim Rasheedy, Ahmed Suwailem Saleem Almehmadi, Fatma Saleh Alharbi, Waleed Mohammed Omar Almahaily, Abdulrahman Saad Alsaedi

European Journal of Molecular & Clinical Medicine, 2019, Volume 6, Issue 1, Pages 274-287

Background
Smoking is now well established as a recognized cause of cancer, lung disease, coronary heart disease, and stroke; it is considered the single most important avoidable cause of premature morbidity and mortality in the world. Additionally, epidemiological studies have reported positive associations between smoking and psychiatric disorders. Several studies have found high rates of smoking among selected populations of persons with mental illness, whereas general population surveys have demonstrated a significant association between current smoking and psychiatric symptoms.
     The World Health Organization has reported that more than 4 million annual deaths are attributed to tobacco consumption; this is projected to be10 million annually in 2030. Conversely, smoking cessation reduces health risks and improves quality of life. In particular, the cumulative risk of dying of cancer, cardiovascular and lung diseases can be drastically reduced if smokers quit, even at an advanced age.Objective: To assessment the health-related quality of life (HRQL) among Patients Smoking attitudes attending smoking clinics Primary Health Care Centers in Makkah. Aim of the study Aim of the study: The study aimed at assessing the health related quality of life among Patients smoking attitudes attending smoking clinics Primary Health Care Centers in Makkah. Method: A cross-sectional descriptive stud conducted from January, 2019 to December, 2019 in four Primary Healthcare Centers (PHC)in Makkah, the Sample size of Patients Smoking Attitudes attending PHC. Our total participants were (80). Results: the specific medical diseases significantly associated with smoking were Musculoskeletal disorders and  Central nervous system diseases  were (P < 0.001 and=0.033 ) and X2 25.481and 3.554 with the Negative in age (25-35) of the patients was (66.67% and 11.11% ) while in Positive age patients was (33.33% and 83.33%) while all anther medical diseases no significantly associated with smoking .Conclusion . the health related quality of life among Patients smoking attitudes  attending Primary Health Care Centers in Makkah smokers with smoking history show significant impairment in the physical and mental domains of HRQL in comparison to never-smokers. Postgraduate studies, workshops and training are indeed necessary to help PHCPs' to understand the significance of the role they play in implementing SCC for patients, individuals, family and the community effectively.