Online ISSN: 2515-8260

Keywords : stability

Formulation and evaluation of glibenclamide loaded mouth dissolving films with xanthan gum as film forming polymer

Antima Shukla; Nidhi Bhatt

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 1016-1025

Glibenclamide is a BCS class II oral hypoglycemic agent that is widely indicated for the
management of type 2 diabetes mellitus and has the ability to pass through the gastrointestinal
mucosa. The need to rapidly maintain glucose levels in the body is subject to design systems
that can release drugs into the systemic circulation in a very short time. The present study
attempts to prepare glibenclamide loaded mouth dissolving films (GMDFs) using xanthan
gum, as it forms polymers for rapid absorption of the drug in systemic circulation. The solvent
casting method was used to produce oral disruptive film containing glibenclamide. All
formulations exhibited instant release drug release, rapid dissolution and optimal mechanical
strength. The GMDF3 formulation exhibited the highest drug content (96.1±5.89) and all
aggregates were found to decompose within 40 seconds. The GMDF1, GMDF2 and GMDF3
formulas were able to release 97, 96 and 98% 10 drugs at the end of 10 minutes, respectively,
while GMDF4 and GMDF5 were able to release 94 and 90%, respectively. The results of rapid
stability studies have shown that all aggregates are stable under extreme conditions

Stability and Hopf Bifurcation Analysis of Hepatitis B Infection Model with CTL Response Delay

M. Aniji; N. Kavitha; S. Balamuralitharan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 74-90

In this paper, the Hepatitis B Virus (HBV) infectious model with Cytotoxic T-Lymphocyte (CTL) response delay and its effect on the stability of equilibrium has been investigated. The boundedness and non-negativity solutions of the proposed model were verified. The local stability of virus-free equilibrium and the infected equilibrium were determined by the basic reproduction number R0. Further, the existence of Hopf bifurcation at the infected equilibrium of CTL response was also observed. Using different set of parameters, the empirical findings in the study are shown with numerical simulations.

Review on Property of Ca-Hexa Ferrites in Material Development

Jay Singh Sagar; A. P. Bhat; K. G. Rewatkar; D. K. Sahu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4011-4037

The requirement for present-day magnetics in the new time of innovation Researchers was persuaded by materials to do the investigation on hexagonal Because of their wide uses as attractive materials, ferrites principally. Ferrites have gotten basic for business and innovation the same. Uses. Uses. Their executions depend on extremely basic highlights. Viz., Magnetization of immersion, high electrical resistivity, low electrical resistivity, Chemical Stability, and Losses. The nanosize end, uncommon and exceptional It has procured mechanically interesting resources. Nanoparticles, on the other hand, maybe changed with different forms of nano-particles Structures by various methods of synthesis and substitutions to Boost their attributes. The most popular magnetic applications are Recording, products for data storage, ferrofluids, and distribution of medicines.
The combustion of the solution and hydrothermal synthesis results from the elite. Structural characteristics are described as the compound and its structural, electrical, and magnetic properties are Reviewed based on the synthesis process.


Anupama Deepak; Dhanraj Ganapathy; M. Jeevitha

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1254-1262

Impression making is an important part of replacement of the teeth. In complete dentures, secondary impression techniques play a major role in the fabrication of the prosthesis, as they help in recording accurate borders and extension on the impression. Recording the secondary impression plays a major role in the retention, resistance and support. The aim of this study was to assess the prevalence of types of secondary impression techniques used by dentists in complete denture patients. This was a cross sectional study containing sample size of 200. This study was conducted in a university setting. Data was collected from a digital case sheet record and categorised into mucocompressive, mucostatic and selective pressure techniques. Data was then entered in MS Excel Sheets and statistically analysed using IBM SPSS Version
20.0 and graphically represented. Selective pressure impression techniques (42.3%) was the most prevalent type used among dentists. Impression techniques play a major role in the fabrication of denture for its retention, resistance and support.

Concurrent effects of attentional focus on postural sway during quiet standing in chronic stroke patients

Sang Heon Jeong; Byoung Sun Chu; Young Uk Ryu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4017-4025

The purpose of this study was to investigate the effects of attentional focus on static postural control in chronic stroke patients. Twenty four subjects diagnosed with chronic stroke participated in the experiment. All subjects maintained quiet standing on a force plate for 30 s with three attentional focus conditions: baseline (BL), internal focus (IF), andexternal focus (EF). No instructions regarding attentional focus were given to the subjects for the BL condition. The subjects were instructed to stand with their attention focused on their feet for the IF condition. Under the EF condition, the subjects were first instructed to check red markers indicated on the force plate. Then the subjects were asked to look front but to concentrate on the markers. The results demonstrated that the EF condition reduced the amount and instability of postural sway more than the other attentional focus conditions. The effects of attentional focus on postural sway were only exhibited in the mediolateral direction. This study suggests that directing attention focused on the movement effect that occurs in the external environment around the body may help stroke patients enhance the postural control of quiet standing.This might result from reduced asymmetric weight distribution with external focus. The present results provide a possible use of external focus to stabilize static posture in physical therapy for patients with stroke.