Online ISSN: 2515-8260

Keywords : Anti-inflammatory

In-vivo analgesic and anti-inflammatory evaluation of synthesised novel new chromane and its analogues

Sonia Kamboj, Jasmine Chaudhary, Akash Jain, Randhir Singh

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 2924-2934

The current research protocol was carried to evaluate biological activity of synthesised new chromane and itsanalogues. New chromane {3,5,7-trihydroxy2-(4-hydroxy benzyl) chroman-4-one} isolated from dried leaves of Dillenia indica Linn, family Dilleniaceae is structurally relating with various reported chroman-4-one derivatives displaying remarkable in-vivo analgesic and anti-inflammatory activity.But the literature reveals that 0.8 – 1.0% yield of pure new chromane was obtained in isolation. Followingreported literature data of synthesis and in-silico study (COX2 binding);synthesized new chromane and its derivatives (SI-SX) were investigated for in-vivoanalgesic and anti-inflammatory examination analgesic study (Tail immersion and hot plate method) also displayed the significant analgesic potential of new chromane and its O-alkyl substituents (especially SI) while other synthesized compounds (SV-SX) reported for moderate to mild effects w.r.t. reference drug.Moreover, synthetic new chromane and O-alkyl substituent (SI) exhibited maximum anti-inflammatory activity also in terms of increment of paw volume and percentage inhibition of paw edema while others (SV-SX) showed mild anti-inflammatory action in comparison to referencedrug.

Efficacy Of Prunus Pursica On Plaque Accumulation And Gingival Inflammation: A Double-Blind Clinical Trial.

Robina Tasleem; Alanod Alhaid; Abdulmajeed Almuaddi; AbhinandanRavsaheb Patil; Ayesha Bhavikatti; Manure Md. Javeed; Shaeesta Khaleelahmed Bhavikatti

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 8, Pages 1713-1724

Background: Medicinal use of a plant's seeds, berries, roots, leaves, bark, or flowers is known as herbal medicine, botanical medicine, or phytomedicine. The usage of herbs goes beyond the realm of traditional medicine, but this practice has a long history. Almost one fourth of pharmaceutical drugs are derived from botanicals. One such product is peach scientifically called as "Prunus persica".
Aims: to evaluate the astringent and anti-inflammatory property of Prunus Persica in comparison to chlorhexidine gel.
Settings and design: Randomized, Parallel Group Trial
Material and methods: The present research is a randomized control trial using mouth wash prepared from peach extract for a period of 28 days. The participants were given a random assignment to either the positive control group or the test group. A modified 


Tannita Paul, Dr. Nivedita Sahoo, Subrata Paul, Tarini Kumar Barik, Tanushka Dutta

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 5675-5684

The use of herbal remedies to cure medical issues is extensive. They have been used for generations to cure gingival disease, periodontitis, oral infections, stained teeth, etc. However, there are some research that have gathered data on their impacts. The objective of this review article is to collect and compile data on a few significant herbs that are utilized in dental treatment.

Systematic Review of Moringa oleifera's Potential as Antibacterial and Anti-Inflammatory in the Oral Cavity

Mutmainnah Nurul; Achmad Muhammad Harun

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 10, Pages 144-161

Introduction: Moringa plant is a plant that is spread throughout the region in Indonesia and has many benefits. Moringa oleifera L. plant is also known as the “miracle of tree” because almost all parts of the plant, from the leaves, bark, seeds, fruit of moringa to the roots are used by humans, especially as traditional medicine. Moringa has been proven effective as antibacterial and anti-inflammatory, for example in toothpaste, mouthwash, and root canal irrigation from chitosan. So this systematic review reviews some of the literature on the potential of moringa plants as antibacterial and anti-inflammatory in the oral cavity. Methods: In this systematic review, article searches were conducted on Google Search and Pubmed. Studies published from 2011 to 2020. 104 articles were rated, including 104 articles from electronic databases, 0 from manual search. 96 records were screened, 63 records were excluded, 33 full-text articles were assessed for eligibility and 17 full-text articles were included. Result: There are 8 articles about antibacterial of Moringa oleifera and 10 articles about anti-inflammatory of Moringa oleifera. Conclusion: Based on 18 articles show that chitosan is very potential as a herbal plant that can be antibacterial and anti-inflammatory in the oral cavity.

Study Of Specific Activity Of The Hemostat Liquid Extract

Feruza Saydalieva; Nodira Yunuskhodjaeva; Ziyoda Fayzieva; Manzura Mullajonova; Rokhila Umurzakova; Shakhzoda Ramazonova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3362-3374

Our studies have suggested that the mechanism of action of the sum of flavonoids (liquid extract "Hemostat") from pylori, pylori, nettle and nettle in a ratio of 1: 1: 1 on the blood coagulation process is associated with its effect on the number, adhesion and platelet aggregation, as well as the retractive ability of platelets. It was revealed that the liquid extract "Hemostat" has a pronounced hemostatic effect and in this respect it is noticeably superior to the known preparation of the liquid extract of the shepherd’s bag.

Comparative Study of Xanthine Oxidase Inhibitory Activity Of Methanolic Leaf Extracts Of CalophyllumBlancoi (Bitaog), Diospyrospilosanthera (Bolongeta) and Syzygium Cumini (Duhat)

Jan Asuncion; Mariane May Domingo; Rave Harvey Sienna; Zhaine Marille Villa; Jennifer Anne Loyola

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 4077-4086

Gout is characterized as an inflammation and warmth in the joints. It is associated with hyperuricemia wherein an upregulation of xanthine oxidase in purine degradation leads to increased levels of uric acid in the blood. Gout is not fatal. However, it affects one’s quality of life. Thus, this research primarily focuses in determining the inhibitory activity of xanthine oxidase in the methanolic leaf extract of bitaog (Calophyllumblancoi), bolongeta (Diospyros pilosanthera), and duhat (Syzygiumcumini) in gout. A quantitative-experimental research method was used in the study and the data were obtained by measuring the percent inhibition of the samples using UV-Vis spectrophotometer at 290 nm. The results showed that the methanolic leaf extract of above stated plants exhibited exemplary inhibition in comparison with the standard drug, allopurinol. The IC50 value determines the ability of the inhibitor to decrease the biotransformation of a substrate. The principle behind IC50 is, the lower the value the higher the inhibition. The bitaog (Calophyllumblancoi) trials have the lowest IC50 value with an average of 124.3 after the standard drug, followed by bolongeta (Diospyros pilosanthera) have an average of 155.3 IC50 value. Then duhat (Syzygiumcumini) showed the highest IC50 an average of 208.8.The bitaog (Calophyllumblancoi), next to allopurinol, showed the highest inhibition among all the extracts followed by the bolongeta (Diospyros pilosanthera). The least inhibitory activity was observed in duhat (Syzygiumcumini). Hence, it can be concluded that bitaog (Calophyllumblancoi), bolongeta (Diospyros pilosanthera), and duhat (Syzygiumcumini) can inhibit xanthine oxidase using in vitro analysis


Barani Shankar; Jayalakshmi Somasundaram; Lakshminarayanan Arivarasu

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 1541-1546

Peptic ulcer disease is a multifactorial and complex disease involving gastric and duodenal ulcers. Despite medical advances, the management of peptic ulcer and its complications remains a challenge. An accumulating body of evidence suggests that, among a broad reach of natural molecules, dietary polyphenols with multiple biological mechanisms of action play a pivotal part in the management of gastric and duodenal ulcers. The current review confirmed that dietary polyphenols possess protective and therapeutic potential in peptic ulcer mediated by: improving cytoprotection, re-epithelialization, neovascularization, and angiogenesis; up-regulating tissue growth factors and prostaglandins; down-regulating anti-angiogenic factors; enhancing endothelial nitric oxide synthase-derived NO; suppressing oxidative mucosal damage; amplifying antioxidant performance, antacid, and anti-secretory activity; increasing endogenous mucosal defensive agents; and blocking helicobacter pylori colonization associated gastric morphological changes and gastroduodenal inflammation and ulceration. In addition, anti-inflammatory activity due to down-regulation of proinflammatory cytokines and cellular and intercellular adhesion agents, suppressing leukocyte-endothelium interaction, inhibiting nuclear signaling pathways of inflammatory process, and modulating intracellular transduction and transcription pathways have key roles in the anti-ulcer action of dietary polyphenols.Polyphenols ubiquitously present in vegetables and fruits are progressively viewed as natural dietary ingredients vital for a balanced diet. Administration of a sufficient amount of dietary polyphenols in the human diet can result in perfect prevention and treatment of peptic ulcer. In conclusion, administration of a significant amount of dietary polyphenols in the human diet or as part of dietary supplementation along with conventional treatment can result in perfect security and treatment of peptic ulcer. Further well-designed preclinical and clinical tests are recommended in order to recognize higher levels of evidence for the confirmation of bioefficacy and safety of dietary polyphenols in the management of peptic ulcer