Online ISSN: 2515-8260

Keywords : oral

Comparative study of oral iron and intravenous iron sucrose for the treatment of iron deficiency anemia among pregnant women in India

Soubhagya Talawar, Hanumant V Nipanal, Rashmi Naganagoudar

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 1100-1108

Background: Anemia is a major public health problem worldwide, causing an unfavorable status in respect to upcoming pregnancy. About 20-50% world’s population is anemic among them the most common risk factor is pregnancy.
Material and Methods: All pregnant women suffered from iron deficiency anemia with hemoglobulin level 6-10 gm/dl and gestational age 16-32 were included in this study.Total 300 antenatal patients were involved in this study. All women attending antenatal OPD were screened for anemia. All women attending antenatal clinic were screened for anemia between 16-32 weeks of gestation. All participants were subjected to thorough history followed by clinical examination blood investigations such as complete blood count, peripheral blood smear, serum ferritin values, liver and renal function tests, stool examinations for worm infestations and occult blood loss of all cases were carried out and antenatal investigations as per our institution protocol were undertaken. The cases were randomly divided into two groups of 150 each. Oral Group: was given oral iron tablets containing 100 mg of elemental iron and 500 microgram folic acid daily throughout pregnancy. Intravenous Group: was given a 100 mg of elemental iron as iron sucrose. The formula used for calculation of total required IV elemental iron in the form of iron sucrose, that is, Total iron dose required (mg) = 2.4 x weight in kg x (target Hb – actual Hb of patient) g/dl + 500.17 The total calculated TDI was administered within three consecutive days, up to a maximum of 500 mg per day infusion in 500 ml of normal saline over a period of three to four hours. The infusion was given under supervision to avoid any untoward side effects. Any minor or major side effects were documented.

A Study on Submental Island Pedicle Flap (Sipf) in Oral Cavity Reconstruction – A First Hand Experience

Dr. Amit Katlana Dr. Megina Jain Dr. Akshat Dr. Aayush Rai Dr. Murtaza Saifi Dr. Sakshi Bansal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 4, Pages 3737-3741

The aim of this study is to study on submental island pedicle flap (sipf) in oral cavity reconstruction – a first hand experience.Functional results such as deglutition and speech were not affected post-surgery. This study has been carried out on 20 oral carcinoma patients admitted in surgical oncology ward of Index Medical College Hospital & Research Centre, Indore (M.P) and underwent oral reconstruction. Prior to admission, proper screening along with detailed clinical evaluation with detailed history of each patient was done.
Duration of surgery and duration of hospital stay were significantly less. Small to medium sized defects of oral cavity.  Colour and texture of donor and recipient site matches perfectly in SIPF. Donor site defect can be closed primarily. Donor site scar is acceptable and not visible as it is in continuation with upper neck dissection scar.  In male patients growth of hair at the recipient site was a significant problem. SIPF is well suited for small defects and is good alternative for oral reconstruction.

Study of oral manifestations in chronic kidney disease in vindhya Region

Karuna Jindwani , Keshav Singh , Ayush Jain

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 2336-2347

Background: Normal kidney secretes nitrogenous waste product, regulate volume and
acid /base balance of plasma and synthesize erythropoietin, 25-(OH)2- cholecalciferol
and renin. Chronic kidney disease (CKD) is caused by a progressive and irreversible
decline in the number of nephrons. A wide variety of oral manifestations occurs in CKD
patients. Determination and identification of these manifestations will improve the
quality of life in these patients.
Methods: Thus, this cross-sectional study was conducted in the Department of
Medicine, Sanjay Gandhi Memorial Hospital (SGMH), associated with Shyam Shah
Medical College (SSMC), Rewa, in the Vindhya region between February 2019 and
August 2020.
Results: Out of 127 patients, maximum prevalence of oral manifestations occurring was
pallor (93.70%), xerostomia (84.25%), halitosis (72.44%), sore throat (64.56%), lip
pigmentation (63.77%), periodontitis (48.81%). High Urea levels were found to be
highly significant when correlated with halitosis (p<0.00052). Xerostomia was found
significant when correlated with duration of dialysis (<1 year) with p<0.032.
Conclusions: Manifestations of CKD are common during the progression of uremia. In
the patients studied, the impact of CKD on the oral cavity was evidenced by significant
changes, which pointed to an inter-relationship between oral health and CKD.

Evaluation of Serum Interleukin-6 in Lichen Planus

Mohamed Metwalli, MD, Hoda. AIbraheem, MD, Hager Abu bakr MSc. FathiaKhattab MD

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 3603-3611

Background: Lichen planus (LP) is animmune mediated inflammatorydiseaseof skin and
mucous membranes without a clear etiology. Interleukin-6 (IL-6) is a pro-inflammatory
cytokinewith variousbiologicaland pathological impactson immunity, acute phase response
andinflammation. ExcessiveIL-6production can play a role in the pathogenesis of several
pathological conditionslike psoriasis.
Aim:This study aimed to evaluate serum IL-6 levels inLP patients alongwithassessment
ofitscorrelation with disease severity.
Patients and methods: Twenty-one adult patients with LP as well astwenty-one healthy adult
controls were enrolled in the study. The total score of LP severity was estimated for all
patientsby calculation of the affected body surface area in cutaneous LP patients and clinical
scoring system with visual analogue scale for pain assessment for oral LP.Serum IL-6 levels
were measured in all participants using enzyme-linked immunosorbent assay.
Results:The mean serumIL-6 levels were significantly higher in patients than controls (P <
.002). A positive correlation wasnoticed between serum IL-6 with both cutaneous LP (P
<0.004) and oral LP (P <0.005) severities.