European Journal of Molecular & Clinical Medicine

Background: Nonunions of the tibia may be associated with low-density bone tissue, bone loss, adjacent
soft-tissue damage, limb shortening, limb deformities and joint contractures. There is no gold standard
for the treatment of nonunions of the tibia.
Aims and Objectives: The purpose of our study was to assess the results of treatment with the Ilizarov
method in patients with aseptic nonunions of the tibia, depending on the employed treatment strategies
and surgical techniques. To achieve union at nonunion site with correction of limb length discrepancy
and correction of deformity with early function and mobilization.
Materials and Methods: Our study has been taken place, Department of Orthopaedics, Maharaja
Agrasen Medical College, Agroha, Haryana, India. The operators used one of two treatment strategies:
neutral fixation without compression or continued compression. The following were assessed: rates of
union, ASAMI bone scores, ASAMI functional scores, treatment time, complications, duration of
hospital stay. It is prospective study of treatment of aseptic nonunion of shaft tibia. As we have taken 35
patients of tibial nonunion. All relevant pre and perioperative information and complications were
recorded. Also assessment of functional outcome was made.
Results and Observations: In our study we have evaluated the differences in time to union in the
subgroup of patients with at least one risk factor for disturbances in fracture healing. The following risk
factors were considered: diabetes mellitus, corticosteroid therapy, smoking, advanced lower extremity
vascular disease, and alcohol dependence. Sample size in our study was of 32 out of 35 cases has united,
about 91% success rate. The average duration of nonunion was about 14.5 months, average union time
(fixator removal) is about 6.2 months. Two of our patient were showing poor tolerance to Ilizarov
external fixator changed to other modality.

Background: Aging is an undefiable process and as the population ages, the incidence of hip fracture is
anticipated to increase exponentially. Prolonged bed rest further worsens the morbidity and mortality
after a hip fracture. Intertrochanteric femur fracture management in elderly needs more attention to
reduce malunion and increase early mobilisation to reduce mortality and morbidity. Ideal choice of
treatment is internal fixation by intramedullary or extra medullary devices. Intramedullary devices
provide more stable proximal femoral anatomical fixation. Between PFN and PFNA; helical blade in
PFAN provides more stability, better compression and rotational control with lower cut-out rate.
Aims and Observations
a) To assess the factors for functional outcome of PFNA2.
b) Evaluation of effectiveness and stability of PFNA2.
Material and Methods: In our study, we have taken 32 patients with unstable Intertrochanteric femur
fracture between Nov 2020 to Oct 2021 fulfilling inclusion and exclusion criteria were included in this
study and underwent closed reduction and internal fixation by PFNA (n=32). Assessment was done in
terms of demography, preoperative and intraoperative variables, postoperative parameters mainly
functional outcome till 1 year postoperative.
Results: In our study Preoperative variables, AO fracture type were assessed preoperatively. Duration
of surgery, blood loss and fluoroscopy imaging were significantly lower in PFNA as compared to PFN.
Postoperative complications like cut-out rate, shortening, varus malalignment, return to pre-fracture state
were also lower in PFNA group than PFN. Postoperative functional assessment done by Harris Hip Score
shows better outcome in PFNA than other fixation devices.
Conclusion: PFNA reduces duration of surgery, blood loss, fluoroscopy imaging as compared to other
implants. PFNA also offers better postoperative functional outcome.

Background: Among communicable diseases, Leprosy remains a leading cause of peripheral
neuropathy and disability worldwide. Disabilities and deformities are of major concern as it
triggers social, economic and psychosocial problems of leprosy patients. Objectives: To detect
deformities and disabilities of limb in leprosy patients and grading them according to WHO
deformity and disability grading system (2007). Materials & Methods: It was a hospital-based,
cross sectional study. One hundred and forty six patients with leprosy attending the Dermatology,
Venereology and Leprosy outpatient department were included in the study. All patients were
examined for all kinds of deformities of hands, feet and face. Slit skin smear and biopsy was done
in all new cases. Results: Mean age of patients was 38.1(±15.6) years. The mean duration of
disease was 2.6 (±4.1) years. A statistically significant (p<0.001) number of patients with
deformity presented to hospital by 2 years of onset. Proportion of deformities was greater in males,
in farmers and in people belonging to lower socioeconomic status (p=0.008). Multibacillary
patients had higher rate of deformities of hands and feet and a statistically significant (p<0.05)
number of MB patients had grade 2 ocular deformity (WHO 2007).
Conclusion: Early identification of disease and deformities can help in educating the patients
about leprosy and thus prevention of progression to adverse sequelae.

Background: Assessment of age-related variation on morphometric dimensions of Proximal Femoral of males in a known population.
Materials & methods: 25 male femur bones were obtained from department of human anatomy. Two study groups were formed- Less than 50 years of age and more than 50 years of age. Complete demographic and clinical data of all the bones was collected from the data record files. Measurements were done and different morphometric parameters were assessed. All the parameters were compared on the basis of age group.
Results: Mean anteroposterior physeal angle in subjects of less than 50 years and more than 50 years of age was 75.16° and 75.26° respectively. Mean lateral physeal angle among subjects of less than 50 years and more than 50 years of age was 82.28° and 82.01° respectively. Mean neck version among subjects of less than 50 years and more than 50 years was 9.77° and 9.59° respectively. Non-significant results were obtained while comparing the morphometric dimension of male’s femur among different age group.
Conclusion: No significant age-related changes in structural components of proximal femur was observed after fourth to fifth decade of life

Background: The most prevalent form of inflammatory arthritis is rheumatoid arthritis (RA) and it usually involves elbows, feet, wrists, knees, and ankles. The foot is the first region of the body to display RA signs and symptoms for certain patients. This research aimed to assess the prevalence of foot disorders in RA patients, identifying the relationship between the activity of the RA disease and foot disorders, as well as their effect and deformities occurrence.
Patients and methods: A total of 300 RA patients were included in this report. There were 240 women and 60 men, aged between 18 and 74. The following were done to all patients: complete historical review, complete clinical examination, and the evaluation of disease occurrence Complete blood count (CBC), Erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), rheumatoid factor (RF) titer, and anti-cyclic citrullinated peptide (anti-CCP Ab) titer were used and X Ray on foot done to all patients
Results: We found that 31.6% of the study patients had foot deformities. 214 patients (71.3%) had normal gait while 86 patients (28.7.0%) had pathological gait. Hallux valgus was common among old age and obese RA patients. The foot deformities are associated with moderate and high DAS28 activity. Obese RA patients are more susceptible to have foot problems 2.89 times more than normal-weight RA patients. 176 patients (58.6%) had narrowing, 97 patients (32.33%) had osteoporosis 87 patients (29.0%) had erosion, 20 patients (6.67%) had bone cyst, 17 patients (5.6%) had subluxation and 14 patients (4.6%) had amalgamation.