European Journal of Molecular & Clinical Medicine

Different levels of periodontal disorders erode the periodontal attachment. In addition to stopping these diseases, we must concentrate on regenerating and replacing the tissues that have been lost. On the other hand, the integration with the soft tissues is crucial to the success of dental implants, which are regarded as a blessing in the history of contemporary dentistry. Regardless of the chosen material and design, a successful outcome can only be obtained with the healing of the soft tissue layer positioned between the implant and the bone. Numerous biomaterials and biological mediators have been developed for years in an effort to restore the injured tissues completely using less invasive methods. Several of them are cited in various articles and evaluations from different sources as being summarized here

Engineering proteins for diverse applications by using evolutionary strategies is currently an active research area. Two broad classifications of protein engineering strategies to develop new or enhanced proteins, include rational and directed evolution approaches. Rational engineering of proteins has found its own limitations of insufficient knowledge about parent proteins, whereas directed evolution finds difficulty in screening, though it does not depend on prior information about the parent proteins. These protein engineering approaches, results in the creation of novel with various desired features. Protein biomaterials are created with a combination of natural/synthetic polymers or engineered proteins/protein domains for its use in biomedical field. Both protein engineering and biomaterials have evolved over time. This review mainly serves to discuss the engineered proteins/protein domains/a combination of natural proteins with synthetic polymers in creating protein biomaterials of enhanced properties for biomedical applications like scaffolds for tissue engineering, wound healing etc. Machine learning is seen as an emerging computational technique that is being explored for use in evolving proteins

Tooth loss is quite common worldwide. For treating a lost tooth, treatments such as dental implants (most common worldwide), fillings (made up of inert dental material), dentures, etc. These techniques can restore all the functions of a normal tooth. But using dental tissues and other dental related materials are still a mystery to the dental world. Pubmed research revealed 117 relevant articles. Out of which a total of ‘33’ systematic reviews and their original citations were included in this review. Tooth regeneration is a very complicated process and needs more depth study on this topic. From many of the researches that were reviewed in this article it was seen that there were many new methods developed but none were approved for applying in real life. Tooth regeneration is a vast topic and requires a lot of knowledge to be understood. This study can be used as reference for future research.

Nanotechnology has rapidly made its way into various areas of science. Nano dentistry refers to the use of nanotechnology for diagnosing, treating and preventing oral and dental diseases. The field of nanotechnology has a great potential. Nano dentistry facilitates faster and to the point, accurate diagnosis. It enhances the properties of dental materials, which facilitates excellent handling properties and makes the material more durable. A systematic search strategy was employed and articles were found using keywords. Literature was taken from databases like PubMed and Google Scholar. Articles that discussed Nanotechnology and Nanodentistry were included. Other articles which had data regarding the applications were also included.A total of about 70 articles were collected initially. Multiple articles were added later from other sources. After eliminating articles that did not meet the inclusion criteria, more than 30 studies were finally obtained. This review summarized the use of Nanodentistry. The applications and future scope were also discussed in detail.