Online ISSN: 2515-8260

Keywords : Cancer Biomarkers

Significance of Complement factor and Immunoglobulin in Helicobacter pylori induced Gastric Cancer

PushpalakshmiGangadharan .; AnanthiSivagnanam .; SubekshaGovindaRajan Ravi; Chaitanya Vattem; Premkumar Karunakaran; Raja JeyaSekar R; Megala Jayaraman; Pushparaj Arunachalam

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 3, Pages 128-142

Background: Gastric cancer (GC) still found to be the predominant cancer in Asia.There were very few reports which were focused on population specific biomarker studies with respect to Helicobacter pylori (H. pylori) induced gastric cancer in India. Hence, we aimed to perform this biomarker study involving H. pylori positive and negative healthy serum samples in comparison with H. pylori positive gastric cancer samples.
Methods: We have adapted Proteome based approaches to identify serum biomarkers in our Indian population samples. For proteins separation and identification, 2D gel electrophoresis with tandem mass spectrometry approach was performed and thirty differentially regulated protein spots were analyzed.