Online ISSN: 2515-8260

Keywords : Acne Vulgaris

Use of Botulinum Toxin in Treatment of Acne Vulgaris

Asmaa Osama Al Azazy, Amany Nassar,Khaled Gharib

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 4, Pages 1312-1319

Background:Acne vulgaris is a common inflammatory disorder involving the pilosebaceous unit. The
pathogenesis is multifactorial, involving four key factors with interrelated mechanisms: increased
sebum production, hyperkeratinization of the follicular infundibulum, inflammation, and
Cutibacterium acnes. Botulinum toxin (BoNT)is a potent neurotoxin protein derived from the
clostridium botulinum bacterium. It exerts its effect at the neuromuscular junction by inhibiting the
release of acetylcholine, which causes temporary chemical denervation. At the cellular level,
botulinum toxin functions by cleaving a synaptic protein (synaptosomal-associated protein of 25 kDA
[SNAP-25]) on the internal surface of neuronal membranes, thereby inhibiting vesicle fusion and
release of acetylcholine.

Comparative Study on Buffered 50% Glycolic Acid and 0.5% Salicylic Acid Solution Vs Jessener’s Solution in Egyptian Patients with Acne Vulgaris.

Rewan Hossam; Elsayed Khater; Mohamed Khater

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 2401-2411

Background: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that is associated with significant psychosocial repercussions. Chemical peeling is a documented option in the treatment of active acne. Glycolic acid belongs to the group of α-hydroxy acids is used as a superficial or medium depth peel in acne treatment Jessner’s solution (JS) peel is formulated by Dr. Max Jessner to minimize complication from resorcinol, namely contact
dermatitis. Salicylic acid also decreases in inflammatory lesions