European Journal of Molecular & Clinical Medicine

Background: Androgenetic alopecia (AGA) is the most common form of hair loss experienced in genetically predisposed individuals. The present study evaluated efficacy and safety of 5% minoxidil and 1 mg finasteride in Androgenetic Alopecia male patients.
Materials & Methods: 74 male Androgenetic Alopecia male patients were divided into 2 groups. Group I patients received minoxidil 5% topical solution 1 ml twice a day and group II received oral finasteride 1 mg tablet once a day. Standardized colour global photographs of the affected area were taken and baseline and post‑treatment photographs were compared.
Results: Age group 20-40 years had 14, 40-60 years had 25 and >60 years had 35 patients. The difference was significant (P< 0.05). The mean scalp hair count in group I before treatment was 94.2 per square centimetre and in group II was 96.4 per square centimetre. The mean scalp hair count in group I after treatment was 116.4 per square centimetre and in group II was 106.2 per square centimetre. The difference was significant (P< 0.05). Score -1 was seen in 3 in group II, 0 in 17 in group I and 10 in group II, 1 in 8 in group I and 6 in group II, 2 in 6 in group I and 8 in group II and 3 in 6 in group I and 10 in group II. The difference was significant (P< 0.05).
Conclusion: Oral 1 mg finasteride was found to be more effective than topical 5% minoxidil in management of Androgenetic Alopecia.

progressive thinning of the scalp. Objective: To compare between minoxidil intradermal injection by derma pen versus dutasteride intradermal injection by derma pen and derma pen alone in the treatment of male pattern baldness. Patients and Methods: This study was conducted on 45 Egyptian males with androgenetic alopecia collected from the Al-Zahraa outpatient clinic from the period 2018 to 2019. Approval from the Research Ethics Committee of Faculty of Medicine for Girls, AL-Azhar University was obtained. All of the participants gave informed consent to participate in the study. Results: In the current study, other adverse effects, such as impotence, ejaculation disorder, or gynecomastia, were not reported. No serious adverse effects were reported. No local side effects in the current study may due to appropriate sterilization of the device and the use of only fully licensed and tested agents together with micro-needling are important.Conclusion: Our study proved that dutasteride, minoxidil injection, and derma pen injection are an effective, safe, and trustworthy treatment for male androgenetic alopecia patients. Treatment of male androgenetic alopecia at any age and any BASP grade of
androgenetic alopecia is possible and effective. Therefore, the study concluded that starting treatment at a younger age and earlier stage of androgenetic alopecia give better results.