European Journal of Molecular & Clinical Medicine

A novel, simple, precise, sensitive, rapid and specific high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Triamcinolone acetonide, Budesonide, Beclomethasone, Mometasone furoate and Fluticasone propionate in various nasal sprays using common mobile phase. The stationary phase used was precoated silica gel 60F₂₅₄ plate. The mobile phase used was a mixture of Toluene: Acetonitrile: Triethyl amine [6.5: 3.5:  0.2, v/v/v]. The detection of spots was carried out densitometrically using a UV detector at 240 nm in absorbance mode. This system was found to give compact spots for Triamcinolone acetonide, Budesonide, Beclomethasone, Mometasone furoate and Fluticasone propionate with Rf values of 0.30, 0.46, 0.55, 0.71 and 0.82, respectively. The method was validated in terms of linearity, accuracy, precision, limit of detection, limit of quantification and specificity. The calibration curve was found to be linear between 100-600 ng/spot for all drugs with significantly high value of correlation coefficient [r² > 0.99]. The limits of detection and quantitation values reveals sensitive determination of all drugs in various formulations using common mobile phase. The low value of percent relative standard deviation reflects the repeatable and precise nature of the developed method. The average percent recovery for all drugs between 98.00 – 102.0% with low value of percent relative standard deviation indicates the accuracy of the method. The comparison of associated spectra at peak points of start, apex and end of the band or spot for all drugs with very good correlation or peak purity [r > 0.99] indicates specificity of the method. The assay results are found in good agreement with the label claim indicates quantification of all drugs without interferences of sample matrix. The proposed method can be used in the quality control of bulk drugs and pharmaceutical dosage forms with very fast, accurate, precise and specific results.

Most quality control programs in blood banking are concerned exclusively with control of research center testing and staff and don't assess different region of the blood donation center or decide the capability of all work force in the presentation of administrative assignments. To accomplish the last objectives in our quality control program, during a 15-month time frame, 1,143 purposeful mistakes were placed into routine parts of all blood donation center exercises and afterward painstakingly checked and controlled. Of 498, 400, and 245 mistakes shipped off the workplace, nursing, and lab regions, separately, 12 (2.4%), 58 (14.5%), and 29 (11.8%) blunders were not recognized. Presentation of this program was likewise joined by a huge expansion in the quantity of genuine blunders that were distinguished and probably had not recently been perceived. The quantity of genuine blunders identified expanded from 4 to 43 to 73 during months 0 to 6, 7 to 12, and 13 to 15 of this review. Examination and recording of every blunder on an Error Report Form has allowed assessment of both faculty and frameworks and ensuing execution of restorative activity

This article discusses the importance of quality management in manufacturing enterprises. The impact of the ISO 9001 Quality Management System on the sustainability of manufacturing enterprises is also presented. The research studied statistical methods of quality control and their details. The study concluded the following:
a) the importance of statistical methods and experimental design methods for the analysis of numerical data;
b) the importance of the operational application of simple graphical, statistical methods for quantitative research instead of using more complex calculation methods after the experiment is completed;
c) to obtain all the benefits of using statistical methods, it is important that personnel involved in product research participate in the statistical analysis. This contributes to the early detection and elimination of any cause of possible deviations.

The article deals with the development of science-based proposals and recommendations to identify problems in the organization of auditing organizations in the country in the context of modernization of the economy and to identify promising areas for its development.The article states that audit of financial statements is a necessary and important tool for the economy development, the results of external quality control of audit work in audit companies shows that timeliness and necessity of making these decisions depend on the quality of audits. The existing theories of classification of subjects of audit quality control show that 3 parts: government (financial ministry), audit public associationsand audit companies must work together, also time by time they should do external quality control of audit work. In this regard, it is necessary to consider the nature of audit quality control and those interested in the quality of audits.