Online ISSN: 2515-8260

Keywords : Left Ventricle

A cadaveric study on the difference in thickness between the right ventricle and the left ventricle of the adult human heart in the Eastern Indian population

Soni Kumari, Md. Zahid Hussain, Sigraf Tarannum, Rashmi Prasad

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 161-166

Aim and objectives: The objective of this study is to determine the thickness difference
between the adult human heart's right and left ventricles, as well as their clinical importance
in the eastern Indian population, and compare it to the incidence in other races throughout the
Introduction: Heart is a muscular motor that supplies blood to all parts of the body so that it
provides oxygen and nutrients to all the body parts. As we all know that this heart muscle
consists of four chambers viz., right atrium, right ventricle, left atrium and left ventricle. The
right ventricle receives from the right atrium and pumps the deoxygenated blood to the lungs.
The left ventricle directly pumps oxygenated blood to the rest of the body parts. The left
ventricle is usually narrower and longer than the right ventricle which extends from its base
of the atrio-ventricular groove to the cardiac apex. Moreover, the left ventricle walls are three
times thicker (8 – 12 mm) than those of the right ventricle which is relatively thin measuring
3 – 5 mm and the ration of the thickness between left to right ventricle is 3:1. There are four
borders of the heart. The right border is completely formed by the right atrium. The inferior
border is formed by the left & right ventricle. The left border is being formed by left ventricle
and little contribution from left atrium. Finally, the superior border is formed by right and left
atrium with the great vessels.

Study of Pulmonary Hypertension in Patients with Chronic Kidney Disease

Meroz Pillarisetty,Ganga Prasad, Aparna

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11633-11650

Background:To study the prevalence of Pulmonary Hypertension (PH) in patients with Chronic Kidney Disease (CKD).
Materials and Methods: The present study assessed the prevalence of PH in 50 patients with CKD, at DR.PSIMS & RF, Chinnavutpalli, Gannavaram.
Results: The commonly affected age group in study population was 31-50 years. The mean age of patients was 48.98±12.53years. Diabetes Mellitus was present in 15 (30%) and Hypertension in 48 (96%).  Majority of the patients were in CKD stage 5, i.e.,46 (92%), CKD stage 4 -3 (6%), CKD stage 3- 1(2%). The prevalence of PH in CKD is 22 (44%). PH was not found in the patient with CKD stage 3. PH was found in 2 of the 3(66.6%) patients with CKD stage 4. Out of the 46 CKD stage 5 patients, 20 (43.4%) had PH. With reference to the severity of PH with CKD, the two patients of PH  CKD stage 4 had moderate PH . Out of the 20 patients of PH with CKD stage 5, 10 patients had mild PH, 9 with moderate PH and 1 with severe PHOn Chest X ray, descending right pulmonary artery dilatation and cardiomegaly were seen in more number of patients with PH, compared to those without PH. (p<0.001). In this study, LV systolic dysfunction was present in 18 out of 50 patients (36%). Among 22 patients with PH, it was present in 13 (59.09%). Among 28 patients without PH, it was present in 5 (17.85%). LV systolic dysfunction was significantly higher among the patients with PH compared to those without PH. The mean EF of all patients with CKD is 55.62± 9.54. The mean EF of patients with PH and without PH in the study was 50.50±9.78% and 59.64±7.26% respectively. (p<0.02). LV diastolic dysfunction was present in 41 out of 50 patients (82%). Among 22 patients with PH, it was present in 20 (90.9%). Among 28 patients without PH, it was present in 21 (75%). Prevalence of LV diastolic dysfunction was significantly higher among the patients with PH, compared to those without PH. RV dysfunction was present in 1(3.6%) and in 10 (45.5%) in patients without PH and in patients with PH respectively. Significant difference was found with RV dysfunction more prominent in patients with PH than in patients without PH (p<0.001). 64%of the patients studied had CKD of less than 6 months including 24%of new cases. 16%of the patients had CKD between 6 months and 1year. 20% had CKD of more than 1yr. In relation to PH, out of the 12 new cases of CKD,7 (31.8%) had PH and 5(17.9%)were without PH. Of the 20 patients having history of CKD less than 6 months (excluding new cases), 7 (31.8%) had PH and 13 (46.4%) were without PH. Out of the 8 patients  of CKD between 6 months and 1 year,4(18.2%) had PH and  4(14.3%)were without PH. In patients having CKD of more than 1 year, 4 (18.2%) had PH and 6 (21.4%) were without PH.
Conclusion: The study showed that PH is common in patients with CKD. Left Ventricular systolic and diastolic dysfunctions are strongly related to the outcome of these patients. Unexplained dyspnoea in patients with CKD must be evaluated for PHPulmonary Hypertension, CKD, Chest X-Ray, Left Ventricle, Mortality, ECG, 2D-Echo


Kamilova Umida Kabirovna; Nuritdinov Nuriddin Anvarkhodjaevich; Zakirova Gulnoza Alisherovna; Khamraev Abror Asrarovich

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1169-1179

The aim of our study was to study the features of impaired left ventricular diastolic function in patients with chronic heart failure, depending on the clinical course of the disease. A total of 131 patients with CHF of ischemic origin with I, II and III FC CHF (men aged 38-60 years, mean age 54.51 ± 6.89 years) were examined. Patients with FC I were 31 (23.7%) patients, with FC II - 51 (38.9%) and FC III - 49 (37.4%) patients. The structural
and functional state of the myocardium and the process of LV remodeling were assessed by echocardiography with Doppler ultrasonography. EchoCG was performed on the device "MEDISON ACCUVIX V20" (South Korea), using a 3.25 MHz transducer in standard echocardiographic positions, transthoracic method in accordance with the recommendations of the American Society of Echocardiography (ASE). In patients with CHF, diastolic function disorders were identified in 74.8% of cases: grade I (impaired relaxation) was recorded in 38.9% (51 patients), grade II - (pseudonormal) in 21.4% (28), type III (reversible restrictive) - in 14.5% (19) patients. An analysis of the grades of diastolic dysfunction showed the predominance of relaxation disorders in 52% of patients and an increase in the number of patients with restrictive type of diastolic dysfunction with an increase in CHF FC. Thus, in 74.8% of CHF patients, impaired LV diastolic function was observed, characterized by its deterioration with the progression of the disease. At the same time, impaired LV diastolic function was characterized to a greater extent by impaired relaxation, and with the progression of the disease, a restrictive type of LVDD impairment.