Online ISSN: 2515-8260

Keywords : lipid

Pre and Post-operative comparative analysis of Serum Lipid profile in patients with Cholelithiasis

Dr. Subhranshu Shekhar, Dr. Piyush Agarwal

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 2984-2987

Background: To compare and analyse the pre and post- operative serum lipid profile in patients with choleliathiasis.
Materials & methods: A total of 30 subjects were enrolled. The age group of 25–60 years were included. Gallstones were collected after cholecystectomy and further divided into categories depending on their shape, size, and texture. Laboratory investigations were done. The results were analysed using SPSS software. Comparison between subjects were done using student's unpaired t-test and P < 0.05 was regarded as statistically significant.
Results: A total of 30 subjects were enrolled. The decrease in mean levels of serum cholesterol was significant after 1 week of surgery. There was a significant increase in serum TGs after 1 week of surgery.
Conclusion: Cholecystectomy can significantly improve lipid levels in patients with gallstones.

Study of Lipids and Lipoprotein Levels in uncomplicated Diabetes Mellitus Patients attending Shadan Hospital

Dr. Samatha Tulla; Dr. Siddique Ahmed Khan; Syeda Ayesha Siddiqua

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 1973-1978

Background: Lipid and lipoprotein levels are interrelated with diabetes mellitus. Abnormalities in the levels of total cholesterol (TC) or triglycerides (TAG) or low-density lipoprotein (LDL) cholesterol or very-low-density lipoprotein (VLDL) cholesterol or high-density lipoprotein (HDL) cholesterol or lipoprotein (a) [Lp (a)] is traditionally named as dyslipidemia. Diabetes mellitus has been known to be associated with lipid disorders and cardiovascular diseases. In patients with diabetes mellitus, dyslipidemia occurs earlier in life, leading to increased morbidity and mortality rates. The study aims to assess the changes in lipids and lipoprotein levels in uncomplicated diabetes mellitus patients.
Methods: A case-control type of study was conducted for 18 months (September 2011 to March 2013) at the Department of General Medicine, Shadan Hospital, Hyderabad. Ethical committee approval was taken before the study from the institutional ethical committee. A total of 120 subjects, 60 non-diabetic (healthy) control subjects with matching age and gender and, 60 cases of subjects with uncomplicated diabetes mellitus were enrolled based on predetermined inclusion and exclusion criteria.
Results: This study was conducted to evaluate the changes in lipids and lipoprotein levels between control (normal and healthy subjects) and case (subjects with uncomplicated diabetes mellitus) groups. The Mean±SD levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and lipoprotein (a) were higher in the cases group and showed statistical significance when compared with the control group.

Estimation of Lipid profile in the cases of Mobile phone addiction and depression

Bhumija Sharma , Afreen Arshad Chowdhary, Bhawani Shankar Modi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 7, Pages 6360-6372

Background: Smartphone technology is causing addiction behaviour, which eventually causes mental and health fatigue. Depression, anxiety are related phenomenon and aim of the present study is to investigate lipid profile and other biochemical parameters in the mobile phone addicted and depressed individuals.
Methods: The present study was conducted in the department of biochemistry of FH Medical college . Mobile addiction scale by KIM and HAMILTON depression scales were used to scrutinize subjects for cases and controls.
Results: Total150 subjects were included with 75 cases and75 controls. Smartphone addiction scores is positively related with the depression scores (p<0.05). Age, SPAS, HAMD were significant between cases and controls (p<0.001). Fasting blood sugar was significant between cases and controls(p=0.031).  Lipid profile was insignificant. In regression analysis  Age , TG and VLDL were found significant for depression with p value  (0.021, 0.001, 0.001)respectively .
Conclusions: There was a close relationship between mobile phone addiction and depression. Together both have not been investigated on biochemical grounds hence  future, longitudinal research should be carried out to better investigate the vibrant changes in the relationship between mobile phone addiction, depression and other biochemical and inflammatory markers.

Assessment of impact of Oral Contraceptives on Lipid Profile in Premenopausal Women

Harmohinder Kumar Attri; Tejinder Singh; Raj Kumar; Kuldeep Kumar; Arun Puri

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3023-3027

Background: World is facing the most serious problem that is population explosion. Contraception method is used worldwide for over birth control or unwanted pregnancies. Hence; the present study was undertaken for assessing the impact of oral contraceptives on lipid profile in Premenopausal Women.
Materials & methods: A total of 30 pre-menopausal subjects were enrolled. All the subjects belonged to the age group of 30 to 40 years. Only those subjects were included in the study group which has been using oral contraceptives for the last 3 months. Another set of 30 subjects with negative history of intake of oral contraceptives were taken as controls. Complete demographic and clinico details of all the patients were obtained. Blood samples of all the patients were obtained and were sent for analysis of lipid profile. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software.
Results: Mean serum cholesterol levels among the patients of the study group and the control group was 196.5 mg% and 181.4 mg% respectively. Mean serum triglyceride levels among the patients of the study group and the control group was 95.4 mg% and 82.6 mg% respectively. Mean serum high density lipoproteins levels among the patients of the study group and the control group was 41.6 mg% and 42.8 mg% respectively. Mean serum
cholesterol levels and serum triglyceride levels among the patients the study group was significantly higher in comparison to the patients of the control group.
Conclusion: Use of oral contraceptives significantly alters the lipid profile in premenopausal women.