European Journal of Molecular & Clinical Medicine

Introduction- Urinary bladder pathology (benign or malignant) are a common cause of morbidity or mortality in general population, so knowing the types of lesions is helpful in management.
Objective- The purpose of this study to find out the histopathological spectrum of urinary bladder lesions in TURBT and cystoscopic biopsies and to study the frequency of different  types of urinary bladder lesions particularly urothelial neoplasm in tertiary care centre of Bihar .
Material & Methods - 100 TURBT specimens of patients undergoing cystoscopic biopsies of all age and both sexes have been studies.
Results- Out of 100 patients undergoing cystoscopic biopsies, 30 cases were nonneoplastic and 70 cases were neoplastic, Out of those 70 cases, 21 were low grade urothelial carcinoma and 27 were high grade urothelial carcinoma.
Conclusion- Our study revealed that neoplastic lesions are more common. Most common age group is 51 to 60 years.  High grade papillary urothelial carcinoma with muscles invasion was the commonest urothelail neoplasm at the time of presentation. Hence inclusion of detrusor muscle in the cystoscopic biopsy is of utmost importance.
 
 

Objectives: In this study we aimed to determine the incidence of BKV infection in patients undergoing chemotherapy for different types of cancer who present with cystitis. This study provides molecular evidence of a possible association between BKV and cystitis in cancer patient treated with chemotherapy. Materials and Methods: The study was performed on urine samples from 85 individuals (45 cancer patients during an episode of cystitis and compared with that detected in the urine of 20 cancer patients with no cystitis and 20 healthy individuals) in order to better evaluate the association of BK virus reactivation with cystitis. Detection of BKV in urine by real time PCR assay was done for all of the three groups. Results: Results on the detection of viral DNA from the urine samples demonstrated that 4 (8.89%) of cancer patients with cystitis, in 1 (5.00%) of cancer patients with no cystitis, while 3 (15.00%) of healthy controls, were positive. Recommendations:Our findings merit more studies to be done in a larger number of patients including multiple centers to help in establishing a causal association.