European Journal of Molecular & Clinical Medicine

Background:Objectives: 1.To establish correlation between Amniotic fluid Optical
density (AFOD), gestational age, birth weight and functional maturity of the
newborn.2.To obtain mean AFOD at spontaneous onset of labor. 3.To study the
functional maturity of the newborns, especially in terms of lung maturity by means of
presence or absence of RDS in babies born out of spontaneous labor and in those born
by elective termination.
Materials and Methods: From November 2019 to November 2021, 80 pregnant women
attending Katuri Medical College in Guntur were studied descriptively. We chose 80
singleton pregnant women in spontaneous labour who had a first trimester ultrasound
and estimated crown rump length. AF samples were taken aseptically during
amniotomy and caesarean section after meticulous hysterotomy from the bulging
membranes. Amniotic fluid optical density measured at 650 nm. All the babies' birth
weights were noted. NICU admission, respiratory distress, etc.
Results: we see few babies born even at 35+ wks are fully mature and do not develop
RDS. Buton the other hand few born even after 40 wks are functionally premature and
develop RDS. Some AFODs match the newborn's functional maturity whereas others
don't. AFOD can assess a fetus's functional maturity. At AFOD 1, newborns are
completely functioning. Babies with AFOD 0.4 are immature and have RDS regardless
of gestational age, while those with AFOD 1+ are fully mature. Those with AFOD 1.75+
had postnatal alterations.
Conclusion: Each foetus has its own maturity potential, which occurs at various
gestational ages and birth weights. AFOD 1.05820.36 babies had functional maturity,
brown skin with little vernix, and no respiratory distress. Amniotic fluid OD.

Despite the intense research, the clinical manifestation of syndromic craniosynostosis patients remains an enigma. Human skull is made up of various bone joints connected by sutures. The sutures fuse in later life after the complete growth ofthe brain. If any of these sutures close early, it may encumber the normal growth of the brain. In craniosynostosis there are disturbances in the growth of the skull which are caused by premature synostosis at one or more cranial sutures, resulting in typical deformities of the vault called as dyscrania. Crouzon syndrome is an emblematic example of craniosynostosis. Cranial malformations in crouzon syndrome depend on the order and rate of progression of sutural synostosis. Thus, physical appearance varies from patient to patient. In this article we intend to compare two patients with crouzon syndrome and a clinically non syndromic patient with beaten metal appearance radiographically. The idea behind this is that each syndromic patient is distinctive and a separate approach for treatment of such patients is desired.