Online ISSN: 2515-8260

Keywords : Ovary

Histopathological Study of Ovarian Lesions at a Tertiary Level Hospital

Samir Ranjan Bhowmik, Ranbir Singh Chawla, Prabhat Kumar Lal

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2724-2729

Background:Ovary is a common site of both neoplastic and non-neoplastic lesions. Ovarian cancer presents with non-specific symptoms and majority of these are in advanced stage. The histopathological patterns of these lesions is helpful in treatment. Hence, the present study was done to determine the prevalence and distribution of various types of lesions of ovary.
Materials and Methods: The present study was cross-sectional descriptive in nature conducted on a total of 100 samples of ovary brought to the department of pathology for histopathology. The specimens were prepared using normal histopathological procedures and findings were noted.
Results: Corpus luteal cyst was the most common non-neoplastic lesion seen (49.1%). Serous cystadenoma (41.9%) was frequent benign lesion seen while Serous adenocarcinoma (4.7%) was the most common malignant lesion. 82.5% of the lesions were benign, 12.3% were malignant and 5.3% were borderline in nature.
Conclusion: Luteal cyst was common in non-neoplastic lesions. Serous cystadenoma was commonest benign tumour, whereas serous cystadenocarcinoma was frequent in malignant ones.


P. Swarnalatha, R.Swarupa Rani, S.Rajasekhar Reddy, Shaik Raja Husne Kalam

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 11940-11953

Background:Ovaries are one of the commonest sites of neoplastic lesions. Ovary is complex in its embryology, histology, steroidogenesis and potential for malignancy and presents wide variation in the clinical and morphological features The clinical stage of the neoplasm per se is inadequate to evaluate the optimum mode of therapy and to compare the therapeutic results. Histological classification of ovarian tumors forms an integral part of this evaluation Determination of various histopathologic patterns of ovarian tumors is very important in diagnosis as well as prognosis of ovarian tumors.Aims and Objectives: To classify and to study the histomorphology of various types of benign, borderline and malignant ovarian tumors and their relation to age and distribution of ovarian neoplasm.
Materials and Methods: During the period of three years from June 2019 to May 2022, 150 ovarian tumors were studied in the department of Pathology ACSR Govt Medical College, Nellore, AP, India.
Results: The overall incidence of ovarian tumors was 14.83% of total hysterectomy and oophorectomy specimens. The surface epithelial tumor formed the commonest tumor type accounting for 92 (66.67%) of ovarian tumors followed by germ cell tumors with 39 (28.26%) cases. The most frequent presentation of ovarian tumors was in the age group of 21-30 year in both benign and malignant tumours. Majority, 122 (88.4%) were benign and 16 (11.59%) were malignant. 94.93%of the tumors were unilateral, of which majority (85.51%) were benign. Majority of benign tumors 84.06%cases had cystic consistency,majority of malignant tumors 7.97%had mixed consistency.Other rare tumours Transitional cell carcinoma, undifferentiated carcinoma, immatureteratoma Haemangioma and lymphangioma were encountered.
Conclusion: A proper histological diagnosis and categorization of ovarian neoplasms in conjunction with clinical findings and recent diagnostic modalities assist in making accurate diagnosis which helps in the proper management.

A cross-sectional prospective assessment of the sonographic morphology of pelvic masses and its correlation with the histopathological diagnosis

Dr. Govind Khatri, Dr. Monika Sharma, Dr. Aditya Kaul, Dr.Ankitaa Thakral, Dr. Pratibha Gupta, Dr. Naresh Tripathi

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 1142-1150

Aim: To evaluate the sonographic morphology of pelvic masses and to correlate with the
histopathological diagnosis of the patients who underwent surgical intervention.
Material and Methods: A cross-sectional prospective study was conducted in the
Department of Radiology Maharishi Markandeswar Medical College and Hospital
Kumarhatti, Solan,Himachal Pradesh for the period of 1 year. Total 100 female patients with
Gynecological masses using high resolution ultrasonography and findings correlated with
histopathology or serial sonographic examination.
Results: Majority of the patients were in the age group of 40-50 years with mean age of 36.3
years. The minimum number was in the age group of below 20 years. The most common
chief complaint of female patients enrolled in our study was pelvic pain 36 (36%) followed
by pain and palpable mass 16(16%).Menstrualirregularity, menorrhagia, post-menopausal
bleeding, infertility, and amenorrhea were the other less common complaints in the female
patients of our study. Out of 100 patients evaluated by ultrasonography 25 (25%) were having
ovarian pathologies and 45(45%) were having uterine pathologies. Eleven patients presented
with localized collection in the fallopian tube pathologies. Few cases there were involvement
8(8%) of vagina. Fibroids were the most common uterine masses.
Conclusion: The USG is most commonly preferred imaging tool to evaluate gynecological
masses. It’s important to differentiate gynecological and non-gynecological masses on
sonography for accurate management of the patient.

A Clinicopathologic Study To Evaluate Neoplastic And Non- Neoplastic Ovarian Lesions In A Tertiary Care Hospital

Dr. Anima Prasad; Dr. Amrish Kumar

European Journal of Molecular & Clinical Medicine, 2021, Volume 8, Issue 2, Pages 1-5

Background: Ovarian cancer is the most frequent cause of death from gynaecological cancers and the fourth most frequent cause of death from cancer in women in Europe, United States and India. The present study was conducted to assess distribution of neoplastic and non- neoplastic ovarian lesions.
Materials & Methods: 74 patients age ranged 18- 48 years was recorded. The histological characterization of ovarian tumour was done according to the International Classification of Diseases, (WHO Classification, 1995).
Results: Age ranged 18- 28 years had 24, 28-38 years had 40 and 38-48 years had 10. Common non- neoplastic lesions were simple serous cyst in 13, luteal cyst in 20, salpingo-oophoritis in 3, hemorrhagic cyst in 8 and endometriosis in 6 patients. Common neoplastic lesions were germ cell tumor seen in 12, epithelial tumors in 6, sex cord stromal tumour in 4 and metastatic tumors in 2 patients. The difference was significant (P< 0.05).
Conclusion: Most common non- neoplastic lesions was simple serous cyst, luteal cyst and hemorrhagic cyst and neoplastic lesions was germ cell tumor.

Monocrotophos toxicity induced hormonal and biochemical disruption in liver and ovary of Cyprinus carpio communis

Sarabjeet Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 3015-3022

The organophosphorus pesticide, monocrotophos induced toxicity in fish’s adobe has been studied to access the biochemical and hormonal disruption caused in the liver and ovary of the fish. Monocrotophos pose serious risk to biochemical parameters, enzyme activities and level of hormones in the fishes. A direct relationship between concentrations of monocrotophos, elevated cholesterol levels and depressed estradiol concentrations have been traced in the study. The elevated levels of cholesterol in the ovary apparently reflect the reduced rate of its utilization for steroid synthesis by the ovary as significant effect of pesticide. The decreased estradiol level causes decreased production of vitellogenin as well as hampers the development of oocytes in ovary of Cyprinus carpio communis which was also evident in the experiments