Online ISSN: 2515-8260

Keywords : dexmeditomidine


INTRAPERITONEAL INSTILLATION OF BUPIVACAINE VS BUPIVACAINE WITH DEXMEDITOMIDINE FOR POST OPERATIVE ANALGESIA IN LSCS

Dr. S. AMUTHAN Dr. RASHMI VIVEK BENGALI Dr.RAJINI SATHANISH

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 4441-4450

Each patient was randomly assigned to one of the two groups of 30 patients each using random table. Group A Patients who received instillation of 20cc of 0.5% Bupivacaine diluted to 40cc with NS intraperitoneally, a total of 40cc. Group B patients who received instillation of 20cc Bupivacaine 0.5% diluted till 40cc with NS with Dexmedetomidine 50mcgs intraperitoneally, a total of 40cc. The patient was blind to the drug injected. All patients underwent thorough medical evaluation and routine lab investigations a day prior to surgery Result; In the present study mean age of Bupivacaine group was 26 and Bupivacaine with Dexmedetomidine study group was 25.65.There was statistically significant difference between two groups of patients in terms of pulse rate and , Systolic BP all the time.The mean VAS as per data, the gradual increase of the VAS scores is comparable, and showed statistical significance between two groups. Comparisons of pain between two groups by Visual Analogue Scale scores were statistically significant at all time point except 6,8 and 24 hour.This study also showed that Bupivacaine provided adequate analgesia for the first  1 to 2 hours when compared to Bupivacaine+Dexmed, which provided adequate analgesia for about 4 to 6 hours.  Conclusion: We concluded that the administration of the intraperitoneal local anaesthetic agent, Bupivacaine in combination with dexmedetomidine can effectively reduce the need for prescribing postoperative analgesic drugs as well as decrease postoperative pain severity in minimal surgery..

Efficacy of dexmedetomidine in attenuation of haemodynamic response to laryngoscopy and endotracheal intubation

Dr CH Nagaraju, Dr Gajagouni Nagaraj Goud, Dr Madanmohan Shiraboina, Dr Narugula Sadanandam

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 10267-10277

Background and Aims: Laryngoscopy and endotracheal intubation are associated with
strong sympathetic responsein the form of tachycardia and hypertension. The aim of
this study was to evaluate the efficacy of intravenous Dexmedetomidine in attenuation
of haemodynamic response to laryngoscopy and endotracheal intubation.
Materials and methods: In this prospective, randomized, double blinded study,A total
of hundred patients of ASA grade I and II between 18 to 50 years of age scheduled for
various elective surgical procedures under general anesthesiawere selected and
randomized into two groups of fifty patients each. Group C received 10 ml of normal
saline intravenously over 10 min, 10 minutes prior to induction. Group D received
injection Dexmedetomidine 0.5μg/kg body weight diluted to 10 ml normal saline
intravenously over 10 min, 10 minutes prior to induction. Baseline parameters like
Heart rate [HR], Systolic blood pressure [SBP], Diastolic blood pressure [DBP] and
Mean arterial pressure [MAP] were recorded in all patients before giving studydrug, 2
,5 and 8 minutes after studydrug, just beforeinduction, immediately after induction,
1,3,4,10 minute after laryngoscopy andintubation.
Results: There was no significant difference in the Age, Gender, body weight of patients
between Group C and Group D. After induction, In group D, there was no statistically
significant increase in the mean HR, SBP, DBP and MAP compared to basal value
whereas in group C, there was a statistically significant increase in mean HR, SBP, DBP
and MAP compared to basal value in group C.
Conclusion: In the present study, Dexmedetomidine at a dose of 0.5μ/kg body weight
given 10 minutes before induction significantly attenuated the haemodynamic responses
to laryngoscopy and tracheal intubation without significant side effects.

Isobaric Levobupivacaine 0.5% Versus Isobaric Levobupivacaine 0.5% With 3mcg Dexmeditomidine In Spinal Anaesthesia- A Comparative Study

Dr. Gopi Kumhar; Dr. Annu Mayank

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 3661-3665

Background: Levobupivacaine is a long acting, amide-type local anaesthetic
that is the S(−) \3- isomer of the racemate bupivacaine. In general, in vitro, in vivo and
human volunteer studies of nerve block indicate that levobupivacaine is as potent as
bupivacaine and produces similar sensory and motor block. Dexmedetomidine is used as
an adjuvant in spinal anesthesia and is associated with prolonged motor and sensory block,
hemodynamic stability, and less requirement of rescue analgesia in 24 h as a result it
facilitates reduction in dose of local anesthetic. Aim of the study: To compare isobaric
levobupivacaine 0.5% versus isobaric levobupivacaine 0.5% with 3 mcg Dexmeditomidine
in spinal anaesthesia. Materials and methods: The present study was conducted in the
Department of Anesthesiology of the medical institution. For the study, we selected a total
of 50 patients in the age group of 20-65 years of physical status American Society of
Anesthesiologists (ASA) Classes I and II admitted for surgeries requiring spinal
anesthesia. An informed written consent was obtained from all the participants after
explaining them the protocol of the study. The patients were randomly grouped into two
groups, Group 1 and Group 2. Group 1 patients received 3 ml (15 mg) of 0.5% isobaric
levobupivacaine + 0.3 ml normal saline, whereas Group 2 patients received 3 ml (15 mg) of
0.5% isobaric levobupivacaine + 0.3 ml (3 μg) dexmedetomidine. Results: It was observed
that the number of male patients in group 1 and 2 was 12 and 14, respectively. The number
of female patients in group 1 and 2 was 13 and 11, respectively. The mean age of patients
in group 1 was 46.28 years and in group 2 was 47.12 years. It was observed that the mean
duration of sensory block in Group 2 was significantly higher than Group 1. The mean
duration of motor block in both the groups was similar and was statistically nonsignificant.
Conclusion: Within the limitations of the present study, it can be concluded
that the duration of sensory block increases with addition of 3 mcg of dexmedetomidine
with Levobupivacaine as compared to plain Levobupivacaine. The results were found to be
statistically significant.