Online ISSN: 2515-8260

Keywords : Nifedipine


A COMPARATIVE STUDY OF LABETALOL AND NIFEDIPINE IN THE MANAGEMENT OF HYPERTENSIVE DISORDERS OF PREGNANCY

Akaraonye, Mercy. A, Confesora Valdez Aquino, Chinelo Igweike, Adaugo Nwanguma, Ayesha Fonseca, Luwaji Aderinmola, Oluwaseun Christiannah Konigbagbe, Srinidhi Cheeti

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 2327-2333

Background: Hypertensive disorders of pregnancy are one of the major causes of morbidity and mortality in both the mother and fetus. The present study was conducted to compare labetalol and nifedipine in the management of hypertensive disorders during pregnancy.
Materials & Methods: 72 pregnant between the ages of with hypertension were divided into two groups Was this a blind study? Oral Labetalol was initially started at a dose of 100 mg twice daily (BD) and a maximum dose of 200 mg thrice daily (TDS) was given. Oral What type of Nifedipine? XR, regular? was initially started with a dose of 10 mg BD and titrated upwards to 20 mg TDS.  Pregnant subjects were monitored daily for blood pressure and fetal well- being.    
Results: Group I received 100 mg labetalol and group II received 10 mg Nifedipine. Gravida I patients were noted to have 62% and 60%, Gravida 2, 24% and 27%, and Gravida 3 14% and 13% reduction in group I and group II respectively. The difference was significant (P< 0.05). SBP (mm Hg) before treatment was 153.4 and 152.4 and after treatment was 126.8 and 138.2 in group I and group II respectively. DBP (mm Hg) before treatment was 104.2 and 106.4 and after treatment was 90.5 and 99.2. MAP (mm Hg) before treatment was 120.2 and 122.6 and after treatment was 101.5 and 112.8 in group I and group II respectively. The difference was significant (P< 0.05).
Conclusion: Labetalol proved to be a better antihypertensive than nifedipine in controlling maternal hypertension and fetal outcome. This effect was significant in systolic blood pressure control compared to diastolic blood pressure control ( p < .05) and (p <.12). This difference was also remarkable in terms of parity as shown in the chart comparing Gravida 1, 2 & 3.

A comparative study between Nifedipine and magnesium sulfate for treatment of preterm labor

DikshaAmbedkar, VimleshKushwaha

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 1, Pages 123-128

Aim: A comparative study between Nifedipine and magnesium sulfate for treatment of
preterm labor.
Methods: Eligible women with preterm labor between 24-37 week gestations were selected
for the study. Nulliparous and multiparous pregnancies with intact membranes, showing
clinical signs of preterm labor were included in this study. The diagnosis of preterm labor is
based on the presence of 4 uterine contractions or more over 30 minutes, each lasting at least
30 seconds, and documented cervical change (dilatation of 0-4 cm and effacement of at least
50%).
Results: 5 patients (5%) after 24 hours, 9 patients (9%) after 48 hours, 7 patients (7%)
after 72 hours and 54 patients (54%) after 7 days had delivery in the nifedipine group and 11
patients (11%) after 24 hours, 5 patients (5%) after 48 hours, 5 patients (5%) after 72 hours
and 62 patients (62%) after 7 days had delivery in the magnesium sulfate group. This
characteristic was not statistically different between the two groups. In this study, 28 patients
(28%) in nifedipine group and 14 patient (14%) in magnesium sulfate group had a failure
treatment (contractions did not subside) and needed to take other tocolytic medications. This
characteristic was also not statistically different between the two groups.
Conclusion: we concluded that the oral nifedipine is a suitable alternative for magnesium
sulfate with the same efficacy and side effects in the management of preterm labor.

ORAL NIFEDIPINE VERSUS ORAL LABETALOL IN THE TREATMENT OF PREGNANCY INDUCED HYPERTENSION

R.P. Patange; Archna V. Rokadhe; Ghori R. Shinde; Sanjay N. Jadhav; Ashitosh Bahulekar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 4136-4141

This study was undertaken to determine the effectiveness of two anti-hypertensive drugs: oral Nifedipine and oral Labetalol in cases of extreme preeclampsia in terms of their side effect profile, BP regulation, time taken to lower BP, and number of doses required. The objective of the study was to calculate the time required to reduce the blood pressure to the target level of 90 / 100 mmHg diastolic and less than 160mmHg systolic.In the labetalol group the mean SBP before treatment was 158mm of Hg which was reduced to 140 mm of Hg. The decline rate in the labetalol group was 11.77%. This study proved that labetalol reduces the BP more effectively than nifedipine and also has minimal side effects with less frequent dosing schedule as compared to nifedipine thus indicating that labetalol is better than nifedipine in lowering the BP in cases of preeclampsia.