European Journal of Molecular & Clinical Medicine

Background & objectives: The COVID-19 pandemic emerged as a major public health emergency affecting the healthcare services all over the world. It is essential to analyse the epidemiologicalandclinicalcharacteristicsofpatientswithCOVID19indifferentpartsofourcountry.Thisstudyhighlights clinical experience in managing patients with COVID-19 at a tertiary care centre in northernIndia.
Methods:Clinicalcharacteristicsandoutcomesofconsecutiveadultpatientsadmittedtoatertiarycare hospitalatAll India Institute of medical Sciences, Patna, Bihar,India,from August12020 toJanuary 31,2021werestudied.ThediagnosisofSARS-CoV-2 infection was confirmed by real-time reverse transcriptase polymerase chain reaction (RT-PCR) on throat and/or nasopharyngeal swabs. All patients were managed according to the institute’s consensus protocol and in accordance with Indian Council of Medical Researchguidelines.
Results: During the study period, 283 patients with SARS-CoV-2 infection were admitted. The history of contact with COVID-19-affected individuals was available in only29 patients. The median age of the patients was 53.85 years (15-95 years), and there were 217 (76.67 %) males. Of the total enrolled patients, only 19 patients (7%)were asymptomatic and rest 264 patients (93%) were symptomatic.Thecommonpresentingcomplaintswerefever in 231 patients(81 %),cough in 217 patients(76 %) and shortness of breath in 204 patients (72%). Out of 283 patients enrolled for the study, 113 patients (39%) had Hypertension as an accompanying comorbid illness, 122 (43%) had Diabetes mellitus, CKD and Hypothyroidism each in 8% of patients, CAD & COPD in 7% and 6% patients respectively
Agemorethan60yearsandpresenceofdiabetesandhypertensionweresignificantlyassociatedwith severeCOVID-19disease.Mortalityof 65 patients ( 23%) wasobserved.
Interpretation&conclusions:MajorityofthepatientswithCOVID-19infectionpresentingtoourhospital were elderly and symptomatic. Fever was noted only in three-fourth of the patients and respiratory symptoms in more than half of the enrolled patients. Patients with comorbidities were more vulnerable to complications. Certain Inflammatory markers like serum CRP, Ferritin, LDH, & D-Dimer have define prognostic value. Triaged classificationofpatientsandprotocol-basedtreatmentresultedingoodoutcomesandlowcasefatality.

Aim: Purpose of our research is to establish the increased incidence of asthma with adolescent age group
Methodology: A cross-sectional, school-based study carried out amongst 1200 children. In
our study, we took into consideration about various demographic patterns like lifestyle
patterns, health issues, as well a comparison between asthmatics and non- asthmatics.
Comparison between the two groups was done by analysing data using Statistical Analysis
Software 25.0.
Results: Among a final sample of 1198 participants, the prevalence of self-reported asthma
was found to be 8.2%. Various characteristics were found significantly different between
the 2 groups including the gender, the weight and dietary patterns. Self –reported
asthmatic were more likely to be males, overweight or obese.
Conclusion: Asthma disease remains prevalent among adolescents and requires higher
awareness and better guidance for its prevention and treatment. Further efforts should
focus on health promotion and as well as improved quality of life so as to prevent this
chronic disease.

COVID-19, the global pandemic affecting economic developments has been regarded as severe pulmonary dysfunction disease. The disease has caused significant mortalities all around the world. The reports suggest that major reason for patients’ death are multiple organ failure, sudden cardiac arrest, severe respiratory dysfunction and body shock. These clinical conditions are majorly linked with COVID-19 comorbidities which are severely affecting disease severity. The present study describes pathophysiological findings associated with multiorgan effect of COVID-19. The study describes possible transmission route of the virus, responsible for gastro intestinal problems. The review of pathophysiological findings in COVID-19 provides a perspective to focus our therapeutic research strategies towards controlling the effect of pathogenic virus on indirectly targeted body organs. The present study will help in controlling disease morbidities as well as preventing long term effects of COVID-19.