Online ISSN: 2515-8260

Keywords : Metabolic syndrome


Kamal Kachhawa, Vivek Jain, Kapil Dev Arya, Poonam Kachhawa, Prashant Harit, M Prasanna Chandra

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 3, Pages 2895-2905

Background: Thyroid dysfunction with metabolic syndrome is recognized risk of atherosclerotic and cardiovascular disease. This study is an effort to investigate the proposed association between these two disease entities and to identify the factors that increase the risk of this association. Methods: A cross sectional study from a teaching hospital in Bhopal city of central India. Total80 patients with metabolic syndrome were included in this study. Metabolic syndrome patients required to fulfil NCEP-ATP III criteria and 80 patients without metabolic syndrome were allocated into the control group. The biochemical parameters like: Fasting Glucose, Lipid Profile, Thyroid Profile, Hs-CRP, FINS, HOMA-IR levels were determined for assessment of metabolic dysfunctions. Results:Fasting blood sugar, Total cholesterol, LDL and TAG level of metabolic syndrome subjects are significantly increases compare than to control group. Abnormal thyroid functions were found in metabolic syndrome group compare to control group. Hs-CRP, FINS and HOMAIR level of metabolic syndrome subjects are significantly increases compare than to control group. Conclusion: Our study suggests that a slight increase in serum TSH might be a risk factor for metabolic syndrome. Therefore, the screening of thyroid level essential to reduce the severity of disease and further investigations are needed to evaluate the mechanism of this correlation.

Association between childhood adversity and metabolic syndrome in patients with mood disorder: In a tertiary healthcare center of North-East India

Dr. Mohit Saini, Dr. Th. Bihari Singh, Dr. Vicky Bakshi, Dr. Sheeba Rana

European Journal of Molecular & Clinical Medicine, 2022, Volume 9, Issue 2, Pages 777-783

Introduction: Physical and mental health have a bidirectional relationship that influences
one another. Several clinical studies have shown that metabolism and emotional state may
share comparable pathways. Although metabolic syndrome and mood disorders often
manifest themselves in adulthood, the likelihood of acquiring these illnesses is influenced by
social and economic conditions in childhood, such as childhood maltreatment, neglect, and
family dysfunctions.
Aim and objectives: To examine the association between childhood adversity and
components of metabolic syndrome in patients with mood disorders and to test whether
specific types of childhood adversity and type of mood disorder interact to worsen metabolic

Assessment of periodontal status in subjects with metabolic syndrome

Anupriya Sharma; Ashish Sharma; Abhimanyu Singh Chauhan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 8311-8315

Background: Metabolic syndrome (MetS), a serious universal health problem, is defined as the clustered presence of three or more conditions, including hyperglycaemia, hypertension, hypertriglyceridemia, low HDL-cholesterol and central obesity. The present study assessed the relationship between MetS and Periodontitis. Materials & Methods: In this case control study, 270 patients with metabolic syndrome aged 18-40 years of both genders (Group I) and equal number of age and gender matched healthy controls (n=270,Group II) were enrolled. Periodontal status was assessed using a community periodontal index (CPI). Score 0 (healthy), 1 (bleeding following probing), 2 (presence of dental calculus), 3 (probing pocket depth between 4 and 5 mm) and 4 (probing pocket depth ≥6 mm) was calculated. Results: Out of 540 patients, males were 258 and females were 282. Healthy periodontium was seen in 12% in group I and 45% in group II, bleeding in 5% in group I and 20% in group II, calculus in 20% in group I and 15% in group II, pockets 4- 5mm in 35% in group I and 13% in group II and pockets >6 mm was seen in 28% in group I and 7% in group II. The difference was significant (P< 0.05). Conclusion: There was poor periodontal status in patients with metabolic syndrome as compared to healthy subjects

Effects Of Obesity On The Serum Levels Of Free And Total Prostate-Specific Antigen In A Sample Of Iraqi Men.

Dr Ziad Hammad Abd; Dr Ruya Abdulhadi M. Saeed; Omar Farhan Ammar (alrawi)

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 142-148

Objectives: the study aims to assess the relationship between obesity and prostatic markers (total prostatic specific antigen (tPSA), and free prostatic specific antigen (fPSA)). Methods: this study was conducted on 127 men aged ≥40 years at The Department of Urology at Al-Ramadi Teaching Hospital. Exclusion criteria were a history of previously diagnosed or treated prostate cancer, the use of prostacare or any drugs that affect the levels of PSA in the serum. Results: the age range of the participants of the study was between 40–80 year. The number of men with normal BMI was 26 (20.47%), 47 men were overweight (37%), 33 men were obese (25.98%), and finally, 21 men were severely obese (16.53%). The mean of parameters total and free prostate-specific antigen (tPSA, fPSA), in the study, were (mean ± SD) (1.683±0.563) ng/ml, (0.537±0.189) ng/ml, respectively. Conclusions: there are no significant relationships between BMI, tPSA, and fPSA, at P≤0.05 in a sample of Iraqi men.

Distribution Of Metabolic Syndrome Components In Patients Younger Than 50 Years Of Age Of Indian Population

Dr. Inder pal Singh; Dr. Kamaldeep kaur; Dr. Lovleen Bhatia; Dr. Ajay pal

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 8, Pages 4786-4793

Background: Prevalence of the metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease and diabetes. Present study aimed to assess the frequency distribution of various components of metabolic syndrome in patients younger than 50 years of age.
Materials and method: The study group consisted of 100 patients less than 50 years of age admitted at Rajindra Hospital with acute coronary disease.
Results: Most common age group was 45-50 years in both males and females, with 66% patients belongs to this age group. 37 patients of ACS with MS, most common component in males was raised blood pressure (SBP and DBP), in females most common component was impaired fasting plasma glucose (FPG). Waist circumference was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MS as compared to patients of ACS without MS. Systolic blood pressure (SBP) was statistically significantly raised in patients of ACS with MetS as compared to patients of ACS without MetS. Fasting plasma glucose (FPG) Serum triglycerides(TGc) and Serum high density lipoproteins (LDL) was statistically significantly raised in patients of ACS
Conclusion: All the five components of metabolic syndrome i.e. waist circumference, systolic blood pressure, fasting plasma glucose, serum triglycerides, serum high density lipoproteins were significantly associated with patients of acute coronary syndrome with metabolic syndrome as compared to patients of acute coronary syndrome without metabolic syndrome.

Features Of Functional Condition Of Kidney In Patients With Heart Failure Reckoning On The Representation Of The Components Of Metabolic Syndrome

Botir T. Daminov; Nodir U. Kayumov; Gulchekhra A. Atakhodjaeva; Umida Sh. Usmanova

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 3430-3443

The aim of the study was to review the features of the functional state of the kidneys in patients with cardiopathy, betting on the presentation of the components of the metabolic syndrome. For the research we examined 197 male patients with chronic heart condition (CHF) of ischemic genesis of II-III functional class (FC) in line with NYHA. Metabolic syndrome in patients with chronic heart failure HFmrEF exacerbates impaired renal function, which has developed together of the most pathogenetic links in chronic heart condition. it's been established that because the metabolic syndrome progresses (attachment of T2DM to other components of the metabolic syndrome), the phenomena of functional kidney failure increase. Evidence of the importance of the metabolic syndrome within the nature of the clinical manifestations of chronic coronary failure HFmrEF is that the established dependence of the identified disorders on the severity of the metabolic syndrome.

Features of the Metabolic Syndrome and Type 2 Diabetes Mellitus in Schizotypal Disorder

Oleg V. Ermilov; Andrey Yu. Tretyakov; Lyubov V. Romasenko; Nina I. Zhernakova; Elizaveta S. Rudycheva; Inna V. Tikhonova; Irina A. Misan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 122-127

Objective: To describe the features and mechanisms of development of metabolic
syndrome (MS), type 2 diabetes melitus (DM2) and intermediate states of glycemia in
psychosis the occurrence of these disorders, the values of total cholesterol (TC),
fractions of high density lipoproteins (HDL), very low density lipoproteins (VLDL),
triglycerides (TG), values of atherogenic coefficient (AC), insulinemia, С-peptidemia,
insulin resistance (IR) the level of glycated hemoglobin (HbA1c) in a sample of patients
with schizophrenia and in mentally healthy individuals.
Materials and methods: The frequency of carbohydrate metabolism disorders (CMD) was
studied. Fasting glycemia was determined, and in the presence of its violation, a glucose
tolerance test was performed. MS components were studied in patients with DM2,
plasma concentrations of TC, HDL, VLDL, TG, C-peptide (CP), insulin and HbA1c were
determined in patients with DM2, AC values and IR indices were calculated using
HOMA-IR and CARO criteria.
Results: CMD in schizophrenia are more common than among mentally healthy subjects,
amounting to 13.1% (p=0.02), and the main condition here is a significant number of
individuals with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT)
among women (CMD p=0.01; IGT p<0.001; IFG p=0.03). A feature of psychiatric
sampling is a decrease in HDL by 16.4% (p=0.03) and an increase in AC by 52%
(p=0.02). Mentally ill men with MS are characterized by a significantly large value of AC
(p=0.019), insulinemia (p=0.02), CP level (p=0.02), HOMA-IR (p=0.01) and CARO
(p=0.04) values than in mentally ill patients with DM2 without MS. In comparison with
the control, regardless of gender, the schizophrenic patients with DM2 have significantly
lower values of insulin (p=0.03), C-peptidemia (p=0.04) and IR, according to the criteria of
HOMA-IR (p=0.01) and CARO (p=0.03).

The spectrum of Non -alcoholic fatty liver disease (NAFLD) in nursing staff.

Charan Bagga; Rajesh Sarode; Sunil Kumar

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2551-2555

Abstract: Background :Looking at non-alcoholic fatty liver infection anthropometric and
biochemical profile with clinical profile and hazard factors. Presentation of NAFLD is
asymptomatic with liver compounds then it advances to cirrhosis later. Commonest reason
for NAFLD is cirrhosis of liver, however reason for essential NAFLD is related with
disabled glucose tolerance, obesity, hypertension, secondary NAFLD and is related with
hypothyroidism, git surgeries, toxins. This study is aimed to see commonness in
understanding with comorbidities albeit accurate aetiology of NAFLD ailment isn't known,
as studies in regards to this in India is inadequate.
Objective To correlate profile & anthropometry of patients of NAFLD

Metabolic Syndrome and Framingham Risk Score in Coronary Artery Disease Cases

Ganesh Shankarrao Thorat; Virendra C. Patil

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 74-79

Metabolic syndrome is a group of simultaneous conditions that expanding your risk of heart disease, stroke, and type 2 diabetes. These conditions include increased blood pressure, high glucose level, and abundance muscle versus fat around the abdomen or triglyceride levels. The objective of the study is to demographic, biochemical, obesity indices and angiographic profile (severity of CAD) of patients with coronary artery disease (CAD). A prospective and observational study involving a number of 971 patients who had undergone coronary angiogram (CAG) for the 18-month CAD assessment. In present study about half of population had significant abnormality on coronary angiogram. Amongst abnormal coronary angiogram about 50% of patients had single vessel disease. The FRS had positive correlation with severity of coronary artery disease and waist circumference. FRS and metabolic syndrome had critical contribution as score and risk factors with presence of and severity of CAD. To conclude it was suggested to incorporate FRS and components of metabolic syndrome for better management and risk stratification of coronary artery disease at large.