Online ISSN: 2515-8260

Keywords : Ethylene glycol

Review on Plants extract as anti-urolithiatic and pathogenesis of urolithiasis induced by ethylene glycol

Sharmila Wahengbam; Dr. Gurmeet Kaur

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 7, Pages 4600-4615

Renal calculi have become a crucial health issue everywhere on the world due to the
adjustments in way of life and nutritive propensities for the present time. As of recently,
People medication or folklore treatment is the significant reliance for the lithogenesis
other than the endoscopic or shock wave lithotripsy. Numerous therapeutic plants were
discovered that have antagonistic effect to urolithiatic properties and have been utilized by
Ayurveda, homoeopathic medicine, or unani framework. In this paper, we analysed some
generally known and as of lately found plant extract which act against lithiasis are
discussed. It is mainly focused on lithiasis induced by ethylene glycol utilizing in-vivo
experiments. Various experiment shows synergic effect of hyperoxaluria, hypercalciuria,
hypocitraturia, decrease in magnesium level and antioxidant properties, change in pH, and
elevation in phosphorus and uric acid level leads to the development of lithiaisis.
Concentration and the type of the extracting solvent are important for the effectiveness of
the extract as it contains different phytochemicals like saponin, flavonoids, phenolic
compounds, alkaloids, etc. Generally plants extract which are anti-microbial and have
antioxidant properties are helpful in reducing stone formation and protecting from renal